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The budding yeast Naumovozyma castellii (syn. Saccharomyces castellii) has been included in comparative genomics studies, functional analyses of centromere DNA elements, and was shown to possess beneficial traits for telomere biology research. To provide useful tools for molecular genetic approaches, we produced stable haploid heterothallic strains from an early ancestral strain derived from the N

Biologically active vitamin B6-derivative pyridoxal 5′-phosphate (PLP) is an essential cofactor in amino acid metabolic pathways. PLP-dependent enzymes catalyze a multitude of chemical reactions but, how reaction diversity of PLP-dependent enzymes is achieved is still not well understood. Such comprehension requires atomic-level structural studies of PLP-dependent enzymes. Neutron diffraction affo

The study investigates how the Best Interests of the Child principle in the UN Children's Rights Convention (Article 3) has been adapted in custody disputes in Egypt, Sweden, and Uzbekistan. Although the Convention on the Rights of the Child offers a common normative benchmark, divergent legal cultures shape its domestic meaning: Egypt is governed by religious and state legal norms intersecting wi

The PRIMARY score was implemented in Prostate Cancer Molecular Imaging Standardized Evaluation (PROMISE) version 2 to improve accuracy for the diagnosis of clinically significant prostate cancer using prostate-specific membrane antigen (PSMA) positron emission tomography (PET). We reviewed overall survival (OS) for patients who underwent PSMA PET for initial staging to evaluate the prognostic valu

INTRODUCTION: Ventilator-associated pneumonia (VAP) is the most frequent healthcare-associated infection in intensive care units and is associated with high morbidity and mortality. Current diagnostic criteria lack specificity, leading to misclassification and unnecessary antibiotic use. Identifying patient subgroups with a common pathophysiological basis (pneumoclusters) may distinguish true VAP

Temporal information in episodic memory reflects how experiences are encoded rather than objective elapsed time, giving rise to systematic distortions. These are particularly evident in emotional contexts, consistent with emotion-related biases in attention. The present study investigated whether emotion-driven distortions in remembered temporal distance were explained by encoding-related attentio

Electrical resistivity tomography (ERT) is a widely used technique for imaging subsurface resistivity distributions, but conventional data acquisition strategies face trade-offs between resolution, efficiency, and data quality. Comprehensive datasets that maximize subsurface information are impractical to measure directly, motivating the development of ERT data reconstruction approaches that can g

c-Jun N-terminal kinases (JNKs) are implicated in both neurodegeneration and mood regulation, including anxiety and depressive-like behaviours. Yet the consequences of JNK inhibition in vivo on protein phosphorylation in the brain remain largely unknown. This study aimed to (1) determine how chronic JNK inhibition altered proteome-wide phosphorylation in hippocampus and nucleus accumbens, regions

Cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) imaging shows myocardial fibrosis and is associated with outcome in repaired Tetralogy of Fallot (rToF). However, patients with rToF have surgical material implanted, also appearing bright in LGE images. Therefore, right ventricular myocardial fibrosis could be overestimated or falsely diagnosed, which may affect prognostic va

What takes place during the monitoring cycles of UN treaty bodies, and what impact do these cycles have both locally and globally? Movement in the Rights Direction explores these questions through the lens of the UN Human Rights Committee, the treaty body responsible for overseeing state compliance with the International Covenant on Civil and Political Rights (ICCPR), often considered the UN’s mos

Animals align their body in relation to different environmental cues, including spontaneous directional responses relative to the geomagnetic field known as magnetic body alignment. The biological significance of this behavior, however, remains undetermined for most taxa. In previous studies, migratory songbirds aligned their body with the cardinal directions of the geomagnetic field and their mig

Klibbiga grenar Föreställ dig, en stilla promenad i lätt vårregn. Känn doften av fuktig jord. Jorddoften kommer från jordlevande bakterierna som kallas Streptomyceter. Då dessa bakterier utgör en av våra viktigaste källor till antibiotika är de särskilt intressanta att studera. Men hur växer de egentligen? I stället för att föröka sig via celldelning bildar dessa bakterier stora nätverk, likt rötStreptomycetes grow as filamentous cells called hyphae. These cells elongate using a polar method of growth where the cell wall synthesis is restricted to the hyphal tips. It has been proved that the protein DivIVA directs the cell wall assembly to the poles and initiate branch formation along the lateral cell wall. Observations of DivIVA shows that it is regulated by AfsK, a Ser/Thr protein kinas

In situ synthesis of oestrogens is of great importance in the development and progression of breast cancer. 17β-hydroxysteroid dehydrogenase (17HSD) type 2 catalyses oxidation from oestradiol to oestrone, and thereby protects the breast epithelial cells from oestradiol. Low expression of 17HSD type 2 has been associated with decreased survival in breast cancer, but no studies have investigated the

Following the Fish—an artistic research project exploring architecture, migration and collective practice through workshop-based methodologies—was presented in 2024 as part of the exhibition UnFold: Exploring Artistic Directions in Architectural Research at Lund University.The project was developed through a series of workshops across Barcelona, Lund and Venice, engaging with the spatial and socia

We have seen that protein kinase Calpha (PKCalpha) is transiently translocated to the plasma membrane by carbachol stimulation of neuroblastoma cells. This is induced by the Ca2+ increase, and PKCalpha does not respond to diacylglycerol (DAG). The unresponsiveness is dependent on structures in the catalytic domain of PKCalpha. This study was designed to investigate if and how the kinase activity a

Questions: (1) Does soil acidification in calcareous sandy grasslands lead to loss of plant diversity? (2) What is the relationship between the soil content of lime and the plant availability of mineral nitrogen (N) and phosphorus (P) in sandy grasslands? Location: Sandy glaciofluvial deposits in south-eastern Sweden covered by xeric sand calcareous grasslands (EU habitat directive 6120). Methods:

The rat neural cell line RN33B has a remarkable ability to undergo region-specific neuronal differentiation after transplantation into the CNS. To further study its neurogenic properties in vivo, we used a recombinant lentiviral vector to genetically label the cells with the Green Fluorescent Protein (GFP) gene before implantation into the striatum/cortex, hippocampus, or mesencephalon of newborn