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Zircon Lu-Hf isotopic data from granites of southern and northwestern Ghana have been used to investigate the contribution of reworked Archaean bedrock to the Birimian crust of Ghana, West African Craton. Zircon from seven localities in southern Ghana and one locality in western Ghana were analysed. Combined U-Pb and Lu-Hf isotope data suggest juvenile crustal addition between 2.3–2.1 Ga, with a s

Aim: Risk factors for development of peripheral arterial disease (PAD) are the same as for atherosclerotic coronary or precerebral disease, and patients with PAD have a high prevalence of concomitant atherosclerotic disease in coronary and precerebral arteries. However, these patients are still less likely to receive appropriate pharmacological secondary prevention than patients with coronary arte

The polyamines are important for a variety of cellular functions, including cell growth. Their intracellular concentrations are controlled by a complex network of regulatory mechanisms, in which antizyme (Az) has a key role. Az reduces the cellular polyamine content by down-regulating both the enzyme catalysing polyamine biosynthesis, ornithine decarboxylase (ODC), and the uptake of polyamines. Th

Parkinson's disease (PD) is characterised by the progressive loss of nigral dopamine neurons and the presence of synucleinopathy. Overexpression of α-synuclein in vivo using viral vectors has opened interesting possibilities to model PD-like pathology in rodents. However, the attempts made so far have failed to show a consistent behavioural phenotype and pronounced dopamine neurodegeneration. Usin

The discovery of microRNAs (miRNAs), which are ~22 nucleotide RNAs that inhibit protein synthesis in a sequence-specific manner and are present in a range of species, has born hope of new therapeutic strategies. miRNAs play important roles in development "Development" of what??and disease, but they remain poorly studied in uropathologies beyond cancer. Here, we discuss biologica

In this paper we evaluate the Swedish Programme for improving energy efficiency in energy-intensive industries (PFE). Since 2005, some 100 energy-intensive companies have entered this five year voluntary agreement (VA) and been exempted from the EU minimum tax on electricity. In return, each company is required to: conduct an energy audit and analysis; identify and invest in profitable electricity

The major histocompatibility complex (MHC) genes are the most polymorphic genes found in the vertebrate genome, and they encode proteins that play an essential role in the adaptive immune response. Many songbirds (passerines) have been shown to have a large number of transcribed MHC class I genes compared to most mammals. To elucidate the reason for this large number of genes, we compared 14 MHC c

Popular Abstract in Swedish Implementeringen av dotter/moderbolagsdirektivet av den 23 juli 1990. Jämförelse mellan olika nationella lagstiftningar som implementerat direktivetAt the crossing between Community law and international tax law, this thesis analyses and compares the Member States' legislation implementing the Parent/Subsidiary Directive of 23 July 1990. Of special interest, the different levels of compliance towards Community law have been proved to be the major obstacle to the harmonisation’s process underlying in the Directive. The procedural differences d

Popular Abstract in Swedish Olika aspekter angående transportmekanismen för aminosyran L-dopa in i så kallade Langerhans celler (LC) i människans överhud och överhudens energimetabolism är undersökta och karaktäriserade. LC har flera olika funktioner i huden, och är en av de mest perifera delarna i vårt immunsystem mot omvärlden. Cellerna vandrar ut i huden från blodkärlssystemet. Cellerna kan äveBased on the discovery of a new amino acid transport system in Langerhans cells (LC), various aspects concerning the L-dopa uptake mechanism into human epidermal LC and the energy metabolism of epidermis have been examined and subsequently characterised. The system lacks any characteristics of other described amino acid transport systems in other cell types. The Falck/Hillarp histofluorescence met

Popular Abstract in Swedish 75% av alla kemiska reaktioner sker på en yta av något slag. En av anledningarna till detta är att många ytor har en katalytisk effekt. Inom kemins värld är en katalysator något som påskyndar en kemisk reaktion utan att själv förbrukas, och ett tydligt exempel på en katalytiskt aktiv yta är en bilkatalysator, vilken i princip består av en varm metallyta. På denna yta omThis work deals with interpretation of experimental surface spectroscopic data with the aid of first-principle calculations. Surface infrared reflection-absorption spectra as well as spectra from the electron spectroscopic methods photoemission and X-ray absorption are considered. In all cases the surface is modeled by a metal cluster with the same (frozen) geometry as part of the surface. The wo

Den dömande verksamheten är en av samhällets mest ingripande former av maktutövning. För att allmänheten ska ha förtroende för denna verksamhet krävs att den framstår som objektiv och därmed legitim. Med utgångspunkt i olika typer av kritik, som förts fram inom såväl den massmediala debatten som den mer rättsinterna aktualiseras frågor om objektivitet och rättstillämpningens legitimitet. FörfattarThe adjudication process is one of society’s most intrusive forms of power. To maintain the general public’s confidence in the judiciary, it is crucial that the judicial activities are perceived as being conducted objectively and hence legitimately. Criminal trials have been subjected to scrutiny and criticism of various kinds in the media as well as in internal debates within the legal discipline

The administration’s legitimacy of the constitutional democracy consist in laws being applied in accordance with the principles which are their foundation. Care about the elderly is the municipals’ responsibility, and this task is regulated in the law of social services and the law of health and healthcare. The legislation grant individual elderly the right to a standard of living that in the law

Renewable energy will play an important role in the transition to a sustainable energy system. With an increased maturity of renewable energy technologies, issues concerning implementation are becoming more important. The decisions and actions of municipalities and other local actors have a significant influence on the implementation of renewable energy. In this thesis challenges to implementation

Reduced urinary bladder capacity is a clinically significant problem. The surgical methods that have been available to treat this, such as urinary diversion or surgically augmenting the bladder by incorporation of intestinal segments, all have serious drawbacks. There is a need to understand how the smooth muscle of the intestine and bladder can interact when brought into close contact surgically,

This thesis considers a class of cooperative n-person games (voting games) in which the voters are spread across an ideological scale. The two most commonly used measures of individual voting power in voting games are the Shapley-Shubik index and the Banzhaf-Coleman index. In both indices, the actors are assumed anomymous and treatad symmetrically. That is, the indices do not take into account tha

Differences in growth conditions during early life have been suggested to cause long-lasting effects on morphology and quality of adult birds. We experimentally investigated the effect of early growth conditions on the expression of sexual ornaments later in life in male ring-necked pheasants (Phasianus colchicus). We also investigated the effects on immune function, as it could be a functional li

The molecular relationship of placental mammals has attracted great interest in recent years. However, 2 crucial and conflicting hypotheses remain, one with respect to the position of the root of the eutherian tree and the other the relationship between the orders Rodentia, Lagomorpha (rabbits, hares), and Primates. Although most mitochondrial (mt) analyses have suggested that rodents have a basal

Exposure to exogenous (oral contraceptives, postmenopausal hormone therapy) and endogenous (number of ovulatory cycles, adiposity) steroid hormones is associated with breast cancer risk. Breast cancer risk associated with these exposures could hypothetically be modified by genes in the steroid hormone synthesis, metabolism and signaling pathways. Estrogen receptors are the first step along the pat