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Environmental contaminants such as persistent organic pollutants (POPs) are man-made bioaccumulative compounds with long half-lives that are found throughout the world as a result of heavy use in a variety of consumer products during the twentieth century. Wildlife and animal studies have long suggested adverse effects of exposure to these compounds on human reproductive health, which, according t
There is an ever-increasing awareness and interest within the clinical research field that has creating a large demand for blood fraction samples as well as other clinical samples. The translational research area is another field that demanding for blood samples, used widely in proteomics, genomics, as well as metabolomics. Blood samples are the global most common biological samples that find its
While negative effects of human disturbance on animals living above the ground have been widely reported, few studies have considered effects on animals occupying cavities or burrows underground. It is generally assumed that, in the absence of direct visual contact, such species are less vulnerable to disturbance. Seabird colonies can support large populations of burrow- and cavity-nesting species
Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of death in cancer and has a 5-year survival of < 5%. Only about 15% of the patients present with a resectable PDAC with potential to undergo "curative" surgery. After surgery, local and systemic recurrence, is though very common. The median survival of resected patients with adjuvant chemotherapy after surgery is only 20-23 mo. T
Childhood sexuality and children's sexual experiences have become increasingly important to study because our knowledge on the impact of sexually abusive experiences on children's developing sexuality has increased. The main aim of this paper was to study aspects of young adults' recollections of their sexual experiences before the age of 13, solitary and shared, mutual as well as coercive. Anonym
This thesis concerns numerical calculations of compressible separated flows, with and without shocks, around wing sections using Large Eddy Simulations (LES). The considered geometries are the NACA 0012 wing section and the ONERA AT15A wing section. Compressible separated flows around wing sections are of considerable interest, for engineering and scientific reasons, since they involve transition,
To evaluate the accuracy of bone mineral composition determination by electron microprobe analysis (EDX) the measurements have been compared to instrumental neutron activation analysis (INAA) and chemical analysis (ICPES). Bone specimens from five femoral heads were used. The trabecular content of calcium (Ca) and phosphorus (P) was analyzed by the three different methods. The EDX method allows fo
PURPOSE: Hereditary prostate cancer accounts for 5% to 10% of all prostate cancer cases. We assessed clinical characteristics and survival in patients with hereditary prostate cancer MATERIALS AND METHODS: The study comprised 201 patients from 62 Swedish hereditary prostate cancer families and 402 controls with prostate cancer who were matched for age and calendar year at diagnosis, and the hospit
BACKGROUND: Oxytocin is released in response to a meal. Further, mRNA for oxytocin and its receptor have been found throughout the gastrointestinal (GI) tract. The aim of this study was therefore to examine whether oxytocin, or the receptor antagonist atosiban, influence the gastric emptying. METHODS: Ten healthy volunteers (five men) were examined regarding gastric emptying at three different occ
Purpose: The expression and regulation of the different isoforms of nitric oxide synthase (NOS) in bladder smooth muscle cells are controversial and to our knowledge have not yet been studied systematically. Therefore, the expression and regulation of NOS were studied in rat bladder smooth muscle cells after stimulation with cytokines, lipopolysaccharide and L-arginine. Materials and Methods: Prim
We present noble gas analyses of sediment-dispersed extraterrestrial chromite grains recovered from similar to 470 Myr old sediments from two quarries (Hallekis and Thorsberg) and of relict chromites in a coeval fossil meteorite from the Gullhogen quarry, all located ill Southern Sweden. Both the sediment-dispersed grains and the meteorite Gullhogen 001 were generated in the L-chondrite parent bod
OBJECTIVE: Data-driven methods for fMRI analysis are useful, for example, when an a priori model of signal variations is unavailable. However, activation sources are typically assumed to be linearly mixed, although non-linear properties of fMRI data, including resting-state data, have been observed. In this work, the non-linear locally linear embedding (LLE) algorithm is introduced for dimensional
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocytes and 20 % non-parenchymal cells, the latter being involved in a secondary phase that may dramatically aggravate the initial damage. Hepatotoxicity, a
Doctoral dissertation Abstract Background The relation between mental illness and accountability, may at its best be described as unclear. A negative correlation them between was established thousands of years ago, and has since formed a more or less self-evident supposition. This dissertation is an effort to test this construction. Aims and hypothesis The overall aim of this thesis is to cla
Recent research has brought into focus the function of switching between verb forms and types of clauses, here labelled ‘gram switching’, as a device for marking non-main clause linking in various types of Arabic and in Biblical Hebrew (Persson forthcoming a; Isaksson, Kammensjö, and Persson 2009; Isaksson 2011, 2013). The study presented here shows that a switch, either in verb form/morphology or
Popular Abstract in Swedish Arbetsplatsens positiva sidor kan förbättras genom ett nytt dialogverktyg! Nu går det att mäta medarbetares positiva upplevelser av arbete. Vanligtvis kopplas människors upplevelser av arbete samman med stress och ohälsa. Men det går att tänka tvärtom, att istället fokusera på allt det positiva som arbete kan ge. När människor mår bra av sitt arbete, blir de också mer The aim of this thesis was to develop and make a quality assessment of a tool, which includes a questionnaire and a dialogue process that could be useful for workplace health promotion from a salutogenic point of view. The studies have been performed within two health care organizations between 2005 and 2009, together with hospital staff. Two questionnaire studies were conducted (n=446 n=505, resp
Radiocarbon analysis of the carbonaceous aerosol allows an apportionment of fossil and non-fossil sources of airborne particulate matter (PM). A chemical separation of total carbon (TC) into its subfractions organic carbon (OC) and elemental carbon (EC) refines this powerful technique, as OC and EC originate from different sources and undergo different processes in the atmosphere. Although C-14 an
Popular Abstract in Swedish Växter påverkar marken rent mekaniskt genom att jordstrukturen ändras när en rot växer, men också kemiskt genom att rötterna utsöndrar organiska molekyler. De organiska molekylerna ökar näringstillgången för mikroorganismerna i marken och därmed ändras tillväxthastigheten och biomassan hos mikroorganismerna. I området runt rötter, rhizosfären, råder det därför en hög miMicrobial activity in soil is generally assumed to be limited by carbon availability. The soil closest to roots, the rhizosphere, is therefore a zone of high microbial activity due to carbon containing substances released by the root. In this work short-term effects in the rhizosphere have been the subject of investigation. I have shown that the thymidine and leucine incorporation techniques are w
Popular Abstract in Swedish Cytokrom P450 är en stor enzymfamilj som finns i alla levande organismer och tar del i både endogen och exogen metabolism. De är primärt mono-oxygenaser och utför en stor mängd reaktioner. Till skillnad från många andra enzymer har de blivit optimerade för att kunna reagera med många olika substrat, istället för att ha höga reaktionshastigheter. I det aktiva sätet har dThe cytochromes P450 are a large enzyme family that is found in all living organisms and takes part in both endogenous and exogenous metabolism. They are primarily mono-oxygenases and perform a wide range of reactions. In contrast to many other enzymes, they have been optimised to react with a wide range of substrates instead of having high reaction rates. In the active site, these enzymes have a
