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While regulatory measures are commonly imposed by states for social, environmental, economical or other reasons and are universally accepted as a part of state sovereignty, they may in various ways adversely affect the interests of foreign investments. Current debates under international investment law centre on whether and when such state interferences, although involving no transfer of legal tit
In this thesis, the biochemical mechanisms for complement activation by endogenous proteins are explored. The short leucine-rich repeat proteins (SLRPs) help organise extracellular matrices. We found that several SLRPs bind C1q and of these, fibromodulin and osteoadherin trigger complement. These two glycoproteins also bind the complement regulator factor H (FH). Our findings may have implication
Malignant brain tumors present a major therapeutic challenge because no selective or efficient treatment is available. Here, we demonstrate that intratumoral administration of human α-lactalbumin made lethal to tumor cells (HAMLET) prolongs survival in a human glioblastoma (GBM) xenograft model, by selective induction of tumor cell apoptosis. HAMLET is a protein-lipid complex that is formed from α
Popular Abstract in Swedish Stroke (slaganfall) orsakas av en propp i hjärnan eller av en hjärnblödning, som hindrar blodflödet till hjärnan. Eftersom hjärnan är beroende av konstant tillförsel av syre och glykos från blodet för sin funktion, leder en blockering av blodflödet till hjärnskador. Stroke är den tredje vanligaste dödsorsaken i västvärlden och den vanligatse orsaken till handikapp hos vStroke is caused by an obstruction of blood flow to a part of the brain, resulting in brain damage. Stroke is the third most common cause of death in the industrialized world, and the primary cause of adult-onset disability. There is a spontaneous recovery of function after stroke but several factors, such as the environment can influence the speed and extent of this recovery. This thesis deals wi
Combining nutritional supplements to achieve synergistic benefit is a common practice in the nutraceutical industry. However, establishing. added health benefit from a combination of natural ingredients is often assumed, untested and without regard to the principle of metabolic competition between the active components. Here, we report on the combination of a cat's claw water extract (C-Med-100, c
Osteoprotegerin (OPG), a secreted member of the tumor necrosis factor receptor family, is a potent inhibitor of osteoclast activation and differentiation. In animal models OPG prevents bone loss, and in humans bone resorption can be reduced by injections of OPG. OPG may also play a role in cardiovascular disease since mice lacking the OPG gene display arterial calcification. In a screening effort
Papers from a conference in Lund, Sweden. The title of the conference was "What's new in the Neolithic". The book brings together the latest research on the Neolithic of northern Europe. In the study of the distant human past, certain events and periods have come to represent decisive passages from one human state to another. From a global perspective, the characteristic feature of the last ten t
In this paper, we introduce two computer simulation models to study molecular exchange between aggregates in a colloidal dispersion. The Brownian motion of the colloidal aggregates is simulated as a random walk with a Gaussian distributed step length. In model I, the exchanging molecules are simulated as discrete particles with the exchange process characterized by desorption, molecular diffusion,
STUDY DESIGN: A randomized, controlled, multicenter trial: 1-year follow-up.OBJECTIVE: To compare the effectiveness of qigong and exercise therapy in subjects with long-term nonspecific neck pain.SUMMARY OF BACKGROUND DATA: The evidence for the benefit of treatment programs focusing on persons with long-term, nonspecific neck pain is conflicting. Several studies have shown support for exercise the
Music is used in many professional contexts that are not associated, in a traditional sense, with either music therapy or music education. How do professionals in different contexts use music, and how do they describe their thoughts about music in their professional work? Those are the main questions in our inquiry, focusing on narratives about music and health in professional relations. In this p
