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Background: Early blight, caused by the necrotrophic fungal pathogen Alternaria solani, is an economically important disease affecting the tuber yield worldwide. The disease is mainly controlled by chemical plant protection agents. However, over-using these chemicals can lead to the evolution of resistant A. solani strains and is environmentally hazardous. Identifying genetic disease resistance fa

Group C and G streptococci (GCS/GGS) and group A streptococci (GAS) belong to β-haemolytic streptococci (BHS). GCS/GGS can further be species determined to S. dysgalactiae, whereas S. pyogenes are GAS. S. dysgalactiae and S. pyogenes cause similar diseases, (e.g., skin and soft tissue infections, erysipelas, bacteraemia, and infective endocarditis (IE)). Erysipelas often presents as a sharply dema

Molecular profiling of extracellular vesicles (EVs) offers novel opportunities for diagnostic applications, but the current major obstacle for clinical translation is the lack of efficient, robust, and reproducible isolation methods. To bridge that gap, we developed a microfluidic, non-contact, and low-input volume compatible acoustic trapping technology for EV isolation that enabled downstream sm

Background: Psychological wellbeing is conceptualized as the full engagement and optimal performance in existential challenges of life. Our understanding of psychological wellbeing is important for us humans to survive, adapt, and thrive during the challenges of the 21st century. Hence, the measurement of psychological wellbeing is one cornerstone for the identification and treatment of both menta

Phosphoglucomutase-1-congenital disorder of glycosylation (PGM1-CDG) is a rare genetic disorder caused by biallelic variants in the PGM1 gene, leading to the deficiency of the PGM1 enzyme. The most common clinical presentations include muscle involvement, failure to thrive, cleft palate, and cardiac involvement. Abnormal serum N-glycosylation, hypoglycemia, and liver function abnormalities includi

Context. Gaia Data Release 3 (Gaia DR3) contains the second release of the combined radial velocities. It is based on the spectra collected during the first 34 months of the nominal mission. The longer time baseline and the improvements of the pipeline made it possible to push the processing limit from GRVS= 12 in Gaia DR2 to GRVS= 14 mag. Aims. We describe the new functionalities implemented for

Hyperbolic paraboloids, “hypars,” are special types of ruled surfaces. Their geometric properties provide them with loadbearing and stabilizing capacities, as well as distinct esthetic qualities. These attributes become evident in numerous applications in buildings, in many of which concrete or timber is used for the construction of the hypars. Hypars could also be relevant in the context of circu

Heat transfer in gas turbine related applications is investigated by steady state liquid crystal thermography (LCT) in this thesis. The work presented includes outlet guide vane heat transfer and gas turbine internal cooling.The heat transfer on the outlet guide vane (OGV) surface and its endwall region is investigated experimentally in a linear cascade test facility. The inlet flow angle is varie

The delineation and characterization of fracturing is important in the successful exploitation of many hydrocarbon reservoirs. Such fracturing often occurs in preferentially aligned sets; if the fractures are of subseismic scale, this may result in seismic anisotropy. Thus, measurements of anisotropy from seismic data may be used to delineate fracture patterns and investigate their properties. Her