Filetype
Sphingosine 1-phosphate (S1P) has pleiotropic biological functions in the regulation of proliferation, survival, migration, inflammation or angiogenesis. S1P acts as intracellular second messenger, as well as extracellular receptor ligand via five G-protein coupled receptors (S1PR1-5). In the brain, S1P regulates neuronal proliferation or apoptosis, excitatory neurotransmission and neuroglia activ
Arctic observing and data systems have been widely recognized as critical infrastructures to support decision making and understanding across sectors in the Arctic and globally. Yet due to broad and persistent issues related to coordination, deployment infrastructure and technology gaps, the Arctic remains among the most poorly observed regions on the planet from the standpoint of conventional obs
Background: ACMG/AMP and AMP/ASCO/CAP have released guidelines for variation interpretation, and ESHG for diagnostic sequencing. These guidelines contain recommendations including the use of computational prediction methods. The guidelines per se and the way they are implemented cause some problems. Methods: Logical reasoning based on domain knowledge. Results: According to the guidelines, several
Introduction: Radiotherapy is an established treatment option for prostate cancer (PCa), both as primary treatment and secondary treatment after radical prostatectomy (RP). Since 1998, detailed data on radiotherapy delivered to Swedish men with PCa (e.g. treatment modalities, absorbed doses, fractionation) have been collated within PCa data Base Sweden (PCBaSe). This study reports patterns of radi
The four-stroke engine was invented by Nikolaus Otto during the second half of the 19th century. Although a lot of technological improvements have been made over the years, the operating principle with four-strokes remains the same. The need and desire of engines with even higher fuel-efficiency is a motivation to study alternative engine concepts. This thesis presents studies of the Double Compre
High-quality biosecurity practices are critical to restarting international tourism. Effective market segmentation improves the communication and efficacy of health advice. Travel frequency is an important basis for health-related consumer segmentation, as it is closely related to risk of greater exposure to infectious diseases. Theoretically grounded studies of tourist biosecurity behavior and tr
The 3.1- and 3.7-km-deep FFC-1 and DGE-1 geothermal explorations wells drilled into the Precambrian crystalline basement on the southern margin of the Fennoscandian Shield are evaluated regarding experiences from drilling, geological conditions, and thermal properties. Both wells penetrate an approximately 2-km-thick succession of sedimentary strata before entering the crystalline basement, domina
Popular Abstract in Swedish Avhandlingen bygger på närläsningar av två av John Cowper Powys främsta romaner, A Glastonbury Romance (1932) och Porius (1951). Ett av dess mål är att påvisa hur en dialogisk läsning av Powys - dvs. en förståelse av samspelet och växlingarna mellan olika röster, tonfall, stilarter och genrer, faktorer som tillsammans bygger upp romanens språk - kan bidragThis study is based on dialogic readings of two of John Cowper Powys´s major novels, A Glastonbury Romance and Porius. The aim of this thesis is to demonstrate the interrelationship in the examined texts between the chain of narrative displacements and the frequent changes of voice and genre. Powys´s cornucopian writing with its wide employment of characteristics from various genres
Popular Abstract in Swedish PAX FÖR MANETER! Evolutionen är den process som format det liv vi ser omkring oss. Ända sedan Darwins tid har man känt till att arter och djurgrupper uppstår genom att det finns en variation mellan individer och att då tillgångarna begränsas (såsom mat eller utrymme) blir det de bäst anpassade som överlever och fortplantar sig. Flercelliga djur har funnits på jorden i kDuring the course of evolution animal complexity and diversity is generated. The last couple of years it has become increasingly clear that morphologically diverse animals share a great deal of their genomic contents, and it must be the expression of regulatory genes in new setting, rather than the generation of new genes, that are fundamental for the generation of diversity. Basal phyla hold a ke
Popular Abstract in Swedish Hur ser vardagen ut för äldre demenssjuka människor? Vad händer när dementa och vårdbiträden dagligen möts i nära och intima relationer? Denna avhandling ger en ingående beskrivning av hur vardagen gestaltar sig på tre gruppboenden för dementa med utgångspunkt från hur dementa och vårdbiträden faktiskt handlar i olika situationer. Ett försök görs att ge ett förståelsepeThis thesis is about the residents and employees at three group homes for older people suffering from dementia. The empirical data comprises princi- pally of participant observation and interviews with caregivers. The aim of the dissertation is to describe and understand what happens during daily life at a group home for elderly suffering from dementia. The ambition is to understand the patterns o
The purpose of this booklet is to offer easy-to-use guidelines for businesses to design and implement circularity strategies into their business model. Specifically, the booklet will provide step-by-step guidance on how to ideate, design, test, and scale novel circular business models. For each stage of this circular business model innovation (CBMI) process a selection of tools and methods will be
Climate and vegetation growth of an area are interrelated processes; both take place on small to global scales. However, climate change and variability impacts on vegetation in most places in the world including Tanzania is of great concern since vegetation supports many socio-economic sectors, and plays a crucial role in atmospheric greenhouse gas moderation. This study aims at investigating the
Titel: Vad ska vi lägga för bud? Seminariedatum: 31 Maj 2024 Kurs: FEKH89, Examensarbete i finansiering på kandidatnivå, 15 högskolepoäng Författare: Gustav Lundin, Adam Paulsson, Jakob Sjögren Handledare: Maria Gårdängen Fem nyckelord: Företagsförvärv, Budpremie, Innovation, Synergier, Patent Forskningsfrågor: Hur påverkar följande variabler budpremien vid förvärv inom Europeiska unionen:Title: What bid should we place? Seminar date: 31 May 2024 Course: FEKH89, Degree Project in Finance, Undergraduate level, 15 ECTS Authors: Gustav Lundin, Adam Paulsson, Jakob Sjögren Advisor: Maria Gårdängen Key words: Acquisitions, Bid premium, Innovation, Synergies, Patent Research question: How do the following variables affect the bid premium for acquisitions within the European Union:
En grundläggande utgångspunkt i den svenska straffrätten är att straffansvaret är individuellt; en person kan enbart straffas för vad den själv gjort, inte för vad någon annan gjort. Brottsliga gärningar begås emellertid ofta av flera personer gemensamt. I sådana fall kan samtliga personer dömas i medgärningsmannaskap för att ”tillsammans och i samförstånd” begått brottet. Domstolarnas tillämpningA fundamental principle in Swedish criminal law is that the criminal liability is individual; a person can only be held accountable for their own actions, not for the actions of others. However, criminal acts are often committed jointly by several individuals. In such cases, the individuals can be convicted in co-perpetratorship for having committed the crime "together and in mutual understan
