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Ceramide plays an important role in regulating cell proliferation and apoptosis. Recent studies indicate that generation of ceramide in the intestine from sphingomyelin hydrolysis may be implicated in colon cancer development. The enzymes that catalyze the further hydrolysis of ceramide in the intestine have, however, not been well investigated. Our data reveal the existence of a ceramidase (EC 3.
In recent years the number of disorders known to affect amino acid synthesis has grown rapidly. Nor is it just the number of disorders that has increased: the associated clinical phenotypes have also expanded spectacularly, primarily due to the advances of next generation sequencing diagnostics. In contrast to the “classical” inborn errors of metabolism in catabolic pathways, in which elevated lev
Background: Detecting and monitoring monoclonal free light immunoglobulin chains in serum is important for managing patients with B-cell neoplasms. Established methods have relied on immunochemistry, with monoclonality determined through an abnormal ratio of free kappa and lambda chains and an increased concentration of the involved chain. This indirect approach has limitations. Mass spectrometric
Dielectric metasurfaces are the state of the art of functional optical devices with light manipulating capabilities. Metasurfaces are planar devices which makes them highly efficient since they do not suffer from propagation effects. These devices consist of sub-wavelength dielectric structures arranged in a lattice, situated on a substrate of dielectric or metallic material. They have been shown
Synovial sarcoma is an aggressive soft tissue tumor that is characterized cytogenetically by the t(X;18)(p11;q11) translocation, resulting in fusion between the SS18 gene on chromosome 18 and one of the SSX genes on the X chromosome. The three fusion genes that have been detected thus far, SS18/SSX1, SS18/SSX2, and SS18/SSX4, account for more than 95% of the synovial sarcomas. Because SS18/SSX fus
Background: About two-thirds of patients with Alzheimer’s disease (AD) are women, mostly because of their longer life-span and the higher prevalence of AD among older persons. A more-pronounced association between AD pathology and dementia (faster brain atrophy) and more-rapid cognitive decline have been reported in women. The AD prognosis might be affected by, e.g., size of cerebral hemispheres,
The Chinese-led Asian Infrastructure Investment Bank (AIIB) started operation in January 2016 in the context of severe criticism from the U.S. government and transnational civil society organizations, but with the support from major Asian and European states. The establishment of this new global governance institution (GGI) raises intriguing questions concerning legitimacy and (de)legitimation. Wh
Looking at the Swedish public sector from a Scandinavian perspective, this chapter argues for a challenged but resilient (although not uniform) Scandi- navian public sector. Sweden is a nation with a long tradition of decentral- ized decision-making, semi-autonomous government agencies and independent local governments. This is considered a receptive context for continuous and incremental moderniz
The neuropeptide calcitonin gene-related peptide is well established as a key player in the pathogenesis of migraine. Clinical studies show calcitonin gene-related peptide levels correlate with migraine attacks, and decreases in this neuropeptide can indicate antimigraine therapy effectiveness. Research has revealed a wide distribution of expression sites for calcitonin gene-related peptide in the
Non-exhaust wear emissions from disc brakes affect the air quality in cities throughout the world. These emissions come from the wear of the contact surfaces of both the pads and disc. The tribological and emissions performance of disc brakes strongly depend on the contact surface characteristics of the pads and discs. The surfaces of conventional pads are scorched by heating it to several hundred
Transportation accounts for a large and growing part of carbon dioxide emissions. With an increasing vehicle fleet worldwide private car use is becoming an acute problem in need of urgent attention and action. Policy interference and cleaner cars are not enough; alternative fuel vehicles such as electric vehicles need to be adopted by consumers as well. Previous research on pro-environmental consu
Background: Pain is a frequent symptom of idiopathic Parkinson’s disease and has a substantial impact on quality of life. The King’s Parkinson’s disease pain scale (KPPS) has become internationally established and is an English-language, standardized, reliable and valid scale for evaluation of pain in idiopathic Parkinson’s disease. This article presents a validated version in German. Method: The
Vargen som art är strikt skyddad i enlighet med EU-rättsliga direktiv. Undantag från skyddet medges endast under vissa specifika förutsättningar. Möjlighet att få prövat i domstol om dessa förutsättningar varit uppfyllda när ett licensjaktbeslut fattats saknades i svensk rätt fram till så sent som den 1 april i år (2016), eftersom det fanns ett överklagandeförbud i jaktförordningen. I stället utgjThe wolf is as a species strictly protected by directives from the EU. Exceptions from the protection are only admitted in accordance with certain specific conditions. Up until the 1st of April 2016 the Swedish Hunting Regulation contained a ban on appeals, meaning that the question of whether the conditions for licensed hunting for wolves were fulfilled or not, could not be reviewed by a court. I
The purpose of this thesis is to clarify how, according to BEPS action 1 and action 7, can the amendments of the “specific activity exemptions” in article 5 paragraph 4 of the OECD Model Tax Convention on Income and Capital (the model convention) counter the issue of an artificial avoidance of a PE status. The main issues that are connected to the concept of a permanent establishment are artificia
Det svenska hyressättningssystemet består i huvudsak av de två komponenterna bruksvärde och det kollektiva förhandlingssystemet. Möjligheten till presumtionshyra infördes 1 juli 2006 och blev en del av det kollektiva förhandlingssystemet. Presumtionshyran är kostnadsbaserad och presumerades vara skälig under tio år (numera 15 år) och ställs under denna tid utanför bruksvärdessystemet. I juli 2016 The 2006 rent reform in Sweden enabled rent in newly-built rental apartments to be based on construction costs rather than objective characteristics that are considered relevant to the tenant, as with the ordinary rental system. This new type, presumption rent, is presumed to be fair during a period of ten years (subsequently prolonged to 15 years) and cannot, during this time, be challenged by th
The queer experience has only become relatively recently a topic of study within migration scholarship. Despite it being seen as a ‘special interest’ field, a lot can be learned about processes of migration decision-making overall, by applying queer theory to it. Furthermore, the concept of place image, which is most often applied to research concerning tourist destinations and the ‘country of ori
Since Actor-Network Theory emerged in the mid-1980s, the approach has transcended disciplinary boundaries and has similarly gained prominence within geography. Moreover, also the main proponents of the approach have endeavoured in linking Actor-Network Theory to geographical lines of inquiry and sought to develop a spatial vocabulary that matches its distinctive thought system. However, few attemp
