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Background: Effects of increased adenosine dose in the assessment of fractional flow reserve (FFR) were studied in relation to FFR results, hemodynamic effects and patient discomfort. FFR require maximal hyperemia mediated by adenosine. Standard dose is 140 μg/kg/min administrated intravenously. Higher doses are commonly used in clinical practice, but an extensive comparison between standard intra

Metallic implants are commonly used as surgical treatments for many orthopedic conditions. The long-term stability of implants relies on an adequate integration with the surrounding bone. Unsuccessful integration could lead to implant loosening. By combining mechanical loading with high-resolution 3D imaging methods, followed by image analysis such as Digital Volume Correlation (DVC), we aim at ev

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, with high hyperdiploidy [51-67 chromosomes] and the t(12;21)(p13;q22) [ETV6/RUNX1 fusion] representing the most frequent abnormalities. Although these arise in utero, there is long latency before overt ALL, showing that additional changes are needed. Gene dysregulation through hypermethylation may be such an event; however

We used in situ hybridization histochemistry to study the expression of the mRNA of the two vesicular monoamine transporters (VMAT1 and VMAT2) during embryonic and postnatal development of the central nervous system (CNS) int he rat. In the adult rat, VMAT2 mRNA is present exclusively in monoaminergic cell groups of the CNS and VMAT1 mRNA was reported to be present in the adrenal medulla and certa

In centers with access to high-end ultrasound machines and expert sonologists, ultrasound is used to detect metastases in regional lymph nodes from melanoma, breast cancer and vulvar cancer. There is, as yet, no international consensus on ultrasound assessment of lymph nodes in any disease or medical condition. The lack of standardized ultrasound nomenclature to describe lymph nodes makes it diffi

This thesis analyses self-employment, sickness absence and early retirement pension among immigrants in Sweden. The empirical analysis investigate a period, 1981-2003, characterized by a transformation from high employment and expansion of the welfare state in the 1980s into a state with high unemployment and tightening social insurance systems during in the 1990s, This thesis goes beyond most pre

In order to provide security and stability for international investors states conclude international investment agreements. International investment agreements guarantee foreign investors specific standards of treatment by the host state within the territory of the state. One standard which usually is included in international investment agreements is the fair and equitable treatment. To create st

I egenskap av lärarstudent med ett år kvar av utbildningen har jag fortfarande vissa svårigheter med att tolka den nya läroplanen, Lgr 11. Jag har därför undersökt hur yrkesaktiva lärare tolkar och hanterar den nya läroplanen. Studien innehåller också en analys av likvärdigheten av lärarnas tolkningar eftersom nya rapporter påpekar bristande likvärdighet i den svenska skolan. Studien är kvalitativAs a teacher student with only one year left until fully educated, I still have some difficulties completely understanding and interpreting the new curriculum, Lgr 11, for the higher grades of Swedish elementary school. Therefore I examined how working teachers tend to interpret and deal with this new curriculum. The thesis also contains an analysis of the teachers’ answers in the perspective of e

Populärvetenskaplig sammanfattning: Återfyllning av energibrunnar har tidigare inte varit aktuellt i någon större grad. De senaste åren har det höjts röster från ett fåtal kommuner om att installationen av dessa system kan skapa en potentiell föroreningsspridning. Trots att installationerna i verkligheten skapat få fall där problem uppstått, fortsätter vissa kommuner att sätta restriktioner mot öp

Throughout the COVID-19 pandemic the post-truth and increasingly radicalized anti-vaccine movement has gained worldwide attention as a major opponent of Covid-restricting efforts. In Germany, the anti-vax movement Querdenker have staged several large-scale protests opposing the ’undemocratic’ government. With increasing online identity expression through fast-paced visual platforms, the Querd

Current cancer treatments can be non-specific, aggressive, and often lead to poor quality of life due to significant side effects. There is a dire need for personalised medicine and accurate tumour subtyping, particularly with cancers with high levels of heterogeneity. Spatial omics is transforming the way in which we understand and treat cancer, paving the way for more patient-specific treatments