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Purpose: In one form of human autosomal recessive retinitis pigmentosa and in retinal degeneration (rd1) mouse, mutation occurs in the genes encoding ß subunit of rod photoreceptor cGMP phosphodiesterase. Therefore, rd1 mutant mouse is an appropriate model for human inherited retinal degeneration studies. Retinal explants are successfully cultured in serum free chemically defined R16 medium to eva

Cognitively-normal people with evidence of β-amyloid (Aβ) pathology and subtle cognitive dysfunction are believed to be at high risk for progression to mild cognitive impairment due to Alzheimer's disease (AD). Clinical trials in later stages of AD typically include a coprimary endpoint to demonstrate efficacy on both cognitive and functional assessments. Recent trials focus on cognitively-normal

Generellt i samhället, såväl bland allmänheten som i rättssystemet, har det konstaterats att det finns en misstro mot kvinnor som anmäler våldtäktsbrott. En återkommande föreställning är att kvinnor ljuger om vad som inträffat när de anmäler dessa brott. Vidare har den svenska våldtäktsprocessen nyligen kritiserats för att innehålla negativa föreställningar om kvinnor. I denna uppsats undersöker j

Background and Objective: Epilepsy is one of the most common neurological disorders, affecting more than 3 million people in Europe. This paper reviews the published evidence regarding the cost effectiveness of second-generation antiepileptic drugs (AEDs). Methods: A systematic literature search was performed, using the databases Academic Search Complete, Econlit, EMBASE and MEDLINE. Health econom

Open Source projects are collaborative processes that generate value for users but generally disallow actors to generate revenue directly from the product that is developed. Nonetheless, many companies are involved in Open Source projects. Therefore it is of interest to study what kind of mechanisms are involved in how companies capture value from Open Source project involvement, and also what kin

From the recent mortality trends in Central and Eastern Europe, it is clear that in the former socialist countries the economic transition had a different effect on male and female mortality: premature death became much more frequent among males, and the gender mortality gap increased as a result. The psycho-social stress hypothesis (Cornia and Paniccia, 2001) explains the Eastern European experie

What drives the adoption of pottery amongst prehistoric foragers in high-latitude environments? Following the long-running interests of archaeology in explaining the origin and dispersal of new technologies, recent years have seen growing efforts to understand what drove the emergence and expansion of early hunter-gatherer pottery use across northern Eurasia. However, many regional dimensions to t

BACKGROUND: Prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT) is useful for selected clinical indications in patients with prostate cancer (PCa) but it may have broader clinical utility owing to the emergence of lutetium-177-PSMA-617 ([177Lu]Lu-PSMA) therapy. However, robust data regarding the impact of PSMA PET/CT on patient management and treat

Human complement component C4b-binding protein (C4BP) is composed of seven alpha-chains and one beta-chain. The alpha- and beta-chains are homologous and both contain multiple copies of short consensus repeats (SCR) and in addition carboxyl-terminal non-repeat regions. Each of the alpha-chains contains a binding site for C4b, whereas the beta-chain binds protein S, a vitamin K-dependent protein in

Evacuation planning is an important activity in disaster management to reduce the effects of disasters on urban communities. It is regarded as a multi-objective optimization problem that involves conflicting spatial objectives and constraints in a decision-making process. Such problems are difficult to solve by traditional methods. However, metaheuristics methods have been shown to be proper solut

ABSTRACT Introduction. Sexual coercion is recognized as a serious societal problem. Correlates and risk factors of sexually abusive behavior in females are not well known. Aim. Etiological theory and empirical study of female perpetrators of sexual coercion are usually based on small or highly selected samples. Specifically, population-based data are needed to elucidate risk/protective factors. Ma