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Popular Abstract in Swedish Man har tidigare sett att patienter med akut myeloisk leukemi (AML) har förhöjda nivåer av det cellcykelreglerande proteinet cyklin A1 och överuttryck av cyklin A1 i de myeloiska cellerna hos transgena möss resulterade i att mössen utvecklade AML. Syftet med avhandlingen var att ytterligare studera uttrycket och regleringen av cyklin A1 i hematopoetiska celler. Vi börja

In ischaemic hearts, endothelin (ET) levels are increased, and vasoconstrictor responses to ET-1 are greatly enhanced. We previously reported that ETB receptors are up-regulated in the smooth muscle layer of coronary arteries after myocardial ischaemia-reperfusion and that the MEK-ERK1/2 signalling pathway is involved in ETB receptor up-regulation. Whether ETs are directly involved in receptor reg

Background: Early detection of prostate cancer (PCa) centers on measurements of prostate-specific antigen (PSA), but current testing practices suffer from lack of specificity and generate many unnecessary prostate biopsies. Soluble urokinase plasminogen activator receptor (uPAR) is present in blood in both intact and cleaved forms. Increased uPAR in blood is correlated with poor prognosis in vario

Retrospective studies have suggested a beneficial effect of lipid-lowering treatment on the progression of aortic stenosis (AS) in milder stages of the disease. In the randomized, placebo-controlled Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study, 4.3 years of combined treatment with simvastatin 40 mg and ezetimibe 10 mg did not reduce aortic valve events (AVEs), while ischemic cardiovas

The activity and substrate degradation pattern of a novel Aspergillus nidulans GH26 endo-β-mannanase (AnMan26A) was investigated using two galactomannan substrates with varying amounts of galactopyranosyl residues. The AnMan26A was characterized in parallel with the GH26 endomannanase from Podospora anserina (PaMan26A) and three GH5 endomannanases from A. nidulans and Trichoderma reesei (AnMan5A,

Popular Abstract in Swedish Aneurysm är ett sjukdomstillstånd som är känt sedan ca 2000 år före vår tideräkning, och bukaortaaneurysm (bråck på stora kroppspulsådern i buken) beskrivs i publikationer från 1500-talet. På 1800-talet försökte man sig på att behandla med ligering, tyvärr med dåligt resultat, och först på 1920-talet beskrivs den första lyckade ligeringen. Behandling med graftrekonstrukThe incidence of abdominal aortic aneurysms (AAA) is increasing. The risk of rupture is related to diameter. However, rupture may occur also in small AAA. To evaluate the size of an aneurysm when related to the predicted normal aortic diameter might be a better predictor of risk. AAA:s, range 40-55 mm were studied in relation to gender. No difference in AAA diameter was found. However, body surfac

This dissertation deals with the rental relations in Malmö between 1880 – 1925. This period witnessed extensive changes in Swedish society, including on the housing market. Industrialization and the rapid pace of urbanization created the basis for a housing market with a strong speculative element. Tenement housing made its breakthrough in Malmö around the turn of the 20th century. New housing are

The need for control of the influent load to a wastewater treatment plant (WWTP) is becoming more important. One reason for this is that there are a number of things that cannot be achieved with plant-focused control. For instance it is hard to avoid sludge loss as a result of poor settling or reducing a too high influent flow rate by in-plant control actions. It is also difficult to reduce the ef

When developing applications for end-user nodes in distributed systems, it is not unusual to find that the business logic part of the solution is relatively inexpensive to develop. The resource intense parts of the solution are more likely to be those of presenting the functionality provided by the node to the end-user, and of connecting the node with the rest of the system. By considering systems