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Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model
CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells
Glucagon is the main counterregulatory hormone in the body. Still, the mechanism involved in the regulation of glucagon secretion from pancreatic alpha cells remains elusive. Dysregulated glucagon secretion is common in patients with Cystic Fibrosis (CF) that develop CF related diabetes (CFRD). CF is caused by a mutation in the Cl- channel Cystic fibrosis transmembrane conductance regulator (CFTR)
A quantum-dot heat engine operating close to the thermodynamic efficiency limits
Cyclical heat engines are a paradigm of classical thermodynamics, but are impractical for miniaturization because they rely on moving parts. A more recent concept is particle-exchange (PE) heat engines, which uses energy filtering to control a thermally driven particle flow between two heat reservoirs1,2. As they do not require moving parts and can be realized in solid-state materials, they are su
The Housing Enabler instrument : Assessing threats to reliability and validity
‘Wet’ eldercare facilities: three strategies on the use of alcohol and illicit substances
Sustainable welfare without growth
All growth‐critical perspectives have the common starting point that the ecological crisis and the increase in social inequality are basic features of high‐consumption capitalism and its spread from North America and Europe to the rest of the world. The common goal is thus to re‐embed productionand consumption patterns into planetary limits through a decrease in material and energy throughputs, pa
Kafka and the COVID-19 epidemic : Why the Sirens’ silence is more deadly than their song
Seeking to examine the implications of social distancing, isolation and the silencing of public spaces brought about by the COVID-19 epidemic, I offer an interpretation of Kafka’s short story ‘The Silence of the Sirens’ contrasting it to the Homeric original. In Homer’s story, Odysseus resists the temptation of the Sirens’ deadly song by having himself tied to the mast of his ship, while his oarsm
Complex by design : Hydrotrope-induced micellar growth in deep eutectic solvents
Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue
Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype
WNT5A-induced activation of the protein kinase C substrate MARCKS is required for melanoma cell invasion
External ventricular drainage catheters : effect of surface heparinization on bacterial colonization and infection
Experiences of the urban green local environment as a factor for well-being among adults : An exploratory qualitative study in southern Sweden
Phase-locked magnetomotive ultrasound imaging of superparamagnetic iron-oxide nanoparticles
Junctional Adhesion Molecule 2 Represents a Subset of Hematopoietic Stem Cells with Enhanced Potential for T Lymphopoiesis
Association measures of claims-based algorithms for common chronic conditions were assessed using regularly collected data in Japan
Family history of autoimmune diseases and risk of gastric cancer : A national cohort study
Treatment with direct oral anticoagulants in patients with upper extremity deep vein thrombosis
Background: Upper extremity deep vein thrombosis (UEDVT) constitutes around 10% of all DVT, and can cause both pulmonary embolism (PE) and postthrombotic syndrome (PTS) in the arm. The incidence of secondary UEDVT is increasing due to widespread use of central venous catheters in patients with cancer and other chronic diseases. The safety and efficacy of using new direct acting oral anti coagulant