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Fracture fixation in an ageing population is challenging and fixation failure increases mortality and societal costs. We report a novel fracture fixation treatment by applying a hydroxyapatite (HA) based biomaterial at the bone-implant interface and biologically activating the biomaterial by systemic administration of a bisphosphonate (zoledronic acid, ZA). We first used an animal model of implant

Metal cutting is a very common operation in the manufacturing industry. Drilling and other hole-making operations perhaps account for 50% of all metal cutting, according to some investigations. All metal cutting including drilling always produces burrs, as a by-product. Actually burrs are nothing but uncut metal at the beginning and at the end of the operations. Yet, despite burr's omnipresence in

Phenotypic modulation of smooth muscle cells (SMCs) plays a key role in vascular disease, including atherosclerosis. Several transcription factors have been suggested to regulate phenotypic modulation of SMCs but the decisive mechanisms remain unknown. Recent reports suggest that specific microRNAs (miRNAs) are involved in SMC differentiation and vascular disease but the global role of miRNAs in p

Lobbyists are working in an ambivalent atmosphere. In Brussels, lobbying is an activity occupying about 20 000 people on a daily basis. They are trying to influence the legislative outcomes from the work of the about 15 000 politicians and employees of the EU institutions (Coen 2007). On one hand the lobbyists are wanted and needed by the politicians and their civil servants. Previous research tel

A dilemma that the iconographer is often faced with when it comes to medieval imagery is what the fantastic hybrid animals actually represent. What are they? What do they mean? On the outer walls of the mid 11th century church of Vä, in north-eastern Scania, there are a number of sadly withered reliefs that may be interpreted as representing a number of different mythological animals with complete

The objective of this thesis is to investigate the synthesis of well-defined polymer nanohybrid materials bearing desirable functionality via surface-initiated atom transfer radical polymerization (SI-ATRP) for potential bioapplications.SI-ATRP is an excellent controlled radical polymerization (CRP) method for the synthesis of polymer nanohybrid by growing polymer brushes (chains) from an interfac

Rationale: Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer’s disease pathogenesis. In clinical practice, trained readers will visually categorise positron emission tomography (PET) scans as either Aβ positive or negative. However, adjunct quantitative analysis is becoming more widely available, where regulatory approved software can currently generate metrics

Metal halide perovskites have attracted immense scientific interest due to their outstanding optoelectronic properties over a widebandgap range. Applications cover a wide range of optoelectronic devices from solar cells, LEDs and lasers to X-ray detectors.[1,2] Particularly in combination with existing silicon technology, perovskite-silicon tandem solar cells, which achieve power conver-sion effic

This thesis explores the escalating and often underestimated issue of bird-window collisions, specifically within the Swedish context, through the lens of the built environment. Globally, hundreds of millions of birds die annually from colliding with glass surfaces, with estimates reaching nearly a billion birds in North America alone. This significant threat is compounded by modern architectural

Rabbit tibialis anterior (TA) and extensor digitorum longus (EDL) muscles are used extensively in studies of stimulation-induced fibre type transformation, but the proportions and sizes of the 2 main fibre types, and the way in which they are distributed within the muscles, have never been described in any detail. In this study, transverse sections were processed by enzyme histochemical and immuno

Popular Abstract in Swedish Avhandlingen undersöker de två behandlingsalternativ, hemodialys och njurtransplantation, som är tillgängliga för personer med njursvikt. I fokus för undersökningen står de former av person- och patientskap som skapas och upprätthålls i hemodialys- och njurtransplantationsvården samt i de njursjukas vardagsliv. Ett av avhandlingens grundläggande antaganden är att dessa This thesis examines the practice of haemodialysis and kidney transplantation, the two medical therapies available for persons with kidney failure, from a phenomenological perspective. A basic assumption made in the thesis is that contemporary biomedicine is deeply embedded in the cultural, historical, economic, and political circumstances provided by the particular local, national, and transnatio

Popular Abstract in Swedish Membranteknik är en separationsteknik där stora partiklar skiljs av från mindre partiklar m.h.a. ett membranfilter. I min forskning har jag tittat på hur membranfiltrering kan användas inom bioteknikindustrin. Jag har tittat på hur mjölksyra kan renas upp från en lösning av jäst "vetemjölsvälling" samt hur första steget i uppreningen av protein A från en industriellt prMembrane filtration is a very gentle separation technique and can be used at low temperatures. This makes it suitable for liquids that contain micro-organisms and/or are heat sensitive, which is often the case in liquids processed in the field of biotechnology. However, one drawback is that these liquids are often very complex, which is a disadvantage when using membrane technology as it makes the