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Intracranial hemorrhage as the initial manifestation of a congenital disorder of glycosylation

Intracranial hemorrhage in a term neonate is a rare event in the absence of an identifiable precipitating factor such as severe thrombocytopenia, mechanical trauma, asphyxia, infections, or congenital vascular malformations. Congenital disorders of glycosylation are a genetically and clinically heterogeneous group of multisystem disorders characterized by the abnormal glycosylation of a number of

Do single right hemisphere infarcts or transient ischaemic attacks result in aprosody?

The ability to perceive and express prosodic qualities of speech was tested in 21 patients with a single focal ischaemic disturbance of the right hemisphere, 14 patients having an infarct and 7 transient ischaemic attacks, and in 21 age-matched normal controls. All patients were predominantly right-handed. None showed signs of aphasia. Pure tone audiometry showed acceptable hearing for speech. The

Card-playing as a Mirror of Society. On Johannes of Rheinfelden's Ludus cartularum moralisatus

Johannes of Rheinfelden’s treatise on card-playing, the Ludus cartularum moralisatus (“the moral meaning of card-playing”) is not only an important source of the history of plays and pastimes but also gives valuable information about late medieval thinking concerning the organization of human society. Johannes writes that the newly introduced cards were something of a revelation for him and that h

Histidine-rich glycoprotein exerts antibacterial activity.

Histidine-rich glycoprotein (HRGP), an abundant heparin-binding protein found in plasma and thrombocytes, exerts antibacterial effects against Gram-positive bacteria (Enterococcus faecalis and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). Fluorescence studies and electron microscopy to assess membrane permeation showed that HRGP induces lysis of E

The Substituted Judgment Standard. Studies on the Ethics of Surrogate Decision Making

Popular Abstract in Swedish Beslutsinkompetenta patienter behöver en ställföreträdande beslutsfattare som kan fatta vårdbeslut för deras räkning. En av de etiska frågor som aktualiseras i detta sammanhang är vilka riktlinjer som bör gälla för sådant beslutsfattande. Enligt ?the Substituted Judgment Standard? (SJS) bör en ställföreträdare fatta det beslut som patienten själv hade fattat, om denne hPatients who are incompetent need a surrogate decision maker to make treatment decisons on their behalf. One of the main ethical questions that arise in this context is what standard ought to govern such decision making. According to the Substituted Judgment Standard (SJS), a surrogate ought to make the decision that the patient would have made, had he or she been competent. Although this standard

A note on wind-tunnel turbulence measurements with DPIV

At moderate Reynolds numbers (10(4) a parts per thousand currency sign Re a parts per thousand currency sign 10(5)), the performance of lifting surfaces is strongly affected by the potential for laminar boundary layer separation and subsequent reattachment and the use of high-quality, low-turbulence wind tunnels is essential in characterising flight at comparatively small scales (where the wing ch

Cetuximab sensitivity associated with oxaliplatin resistance in colorectal cancer.

BACKGROUND: Clinical studies have suggested that the epidermal growth factor receptor (EGFR)-inhibiting antibody cetuximab may have better effect in the third-line treatment of metastatic colorectal cancer, after failure of standard chemotherapy including oxaliplatin, compared to using it up-front in the first line. The reason behind this suggestion is unclear. MATERIALS AND METHODS: The effect o

An empirical evaluation of regression testing based on fix-cache recommendations

Background: The fix-cache approach to regression test selection was proposed to identify the most fault-prone files and corresponding test cases through analysis of fixed defect reports. Aim: The study aims at evaluating the efficiency of this approach, compared to the previous regression test selection strategy in a major corporation, developing embedded systems. Method: We launched a post-hoc

Total Cost Indicators - Operational Performance Indicators for managing environmental and economic efficiency

In this Licentiate Dissertation presents a new model for selecting environmental performance indicators in order to improve environmental management. The suggested Total Cost Indicators support a support a preventive approach to environmental management, where environmental issues are addressed before they arise - and before they become costs. The method of selecting indicators builds on earlier

Changes, Evolution and Bugs - Recommendation Systems for Issue Management

Changes in evolving software systems are often managed using an issue repository. This repository may contribute to information overload in an organization, but it may also help navigating the software system. Software developers spend much effort on issue triage, a task in which the mere number of issue reports becomes a significant challenge. One specific difficulty is to determine whether a new

A laminate-based modelling approach for rate-dependent switching in ferroelectric materials

This contribution focuses on the sequential laminate-based modelling approach for the numerical simulation of the complex electromechanical material behaviour of ferroelectric single crystals. The construction of engineered domain configurations by using the method of sequential lamination in order to study the domain evolution and polarisation switching in ferroelectric single crystals has recent

Property-Oriented Information Systems for Design Prototypes for the BAS•CAAD system

Popular Abstract in Swedish Egenskapsorienterade system (eng: property-oriented) är en ny slags informationssystem som är baserade på begrepp för egenskaper istället för begrepp för ting eller klasser av ting. Genom att fokusera på egenskaper, kan de egenskapsorinterade systemen göras mer flexibla och mer lämpade för de tidiga skedena av design än de traditionella klassorienterade systemen kan varProperty-oriented systems are a new kind of information systems that are based on concepts of properties instead of concepts of things or classes of things. By focusing on properties, the property-oriented systems become more flexible and more suited to the dynamic early stages of design than the traditional class-oriented systems can be. The theoretical framework for property-oriented systems de

Biomonitoring of lead exposure-alternatives to blood

Lead (Pb) is one of the most important models for biomonitoring of exposure, with the blood Pb concentration as a predominant choice in practice and in epidemiology. In this article the alternatives for biomarkers to blood are reviewed. This overview focuses on a number of different qualities that are of importance in the evaluation of a biomarker's usefulness and performance. The qualities scruti