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Molecular profiling of extracellular vesicles (EVs) offers novel opportunities for diagnostic applications, but the current major obstacle for clinical translation is the lack of efficient, robust, and reproducible isolation methods. To bridge that gap, we developed a microfluidic, non-contact, and low-input volume compatible acoustic trapping technology for EV isolation that enabled downstream sm

Background: Psychological wellbeing is conceptualized as the full engagement and optimal performance in existential challenges of life. Our understanding of psychological wellbeing is important for us humans to survive, adapt, and thrive during the challenges of the 21st century. Hence, the measurement of psychological wellbeing is one cornerstone for the identification and treatment of both menta

Phosphoglucomutase-1-congenital disorder of glycosylation (PGM1-CDG) is a rare genetic disorder caused by biallelic variants in the PGM1 gene, leading to the deficiency of the PGM1 enzyme. The most common clinical presentations include muscle involvement, failure to thrive, cleft palate, and cardiac involvement. Abnormal serum N-glycosylation, hypoglycemia, and liver function abnormalities includi

The coastal zone is a dynamic region where the sea meets land, making it highly influenced by environmental conditions such as storm surges, extreme weather events, and coastal erosion. Coastal areas are also characterized by high population densities, significant urban development, and important socio-economic functions such as transportation, trade, tourism and recreation. Consequently, they are

Land cover governs the biogeophysical and biogeochemical feedbacks between the land surface and atmosphere. Holocene vegetation-atmosphere interactions are of particular interest, both to understand the climate effects of intensifying human land use and as a possible explanation for the Holocene temperature conundrum, a widely studied mismatch between simulated and reconstructed temperatures. Prog

A lack of empathy, and particularly its affective components, is a core symptom of behavioural variant frontotemporal dementia (bvFTD). Visual exposure to images of a needle pricking a hand (pain condition) and Q-tips touching a hand (control condition) is an established functional magnetic resonance imaging (fMRI) paradigm used to investigate empathy for pain (EFP; pain condition minus control co

Popular Abstract in Swedish Studien behandlar den sydsvenske bonadsmålaren Johannes Nilssons måleri. Denne produktive målare levde och verkade i Breareds socken i södra Halland 1757­1827. En analys av hans bonader visar att han i många stycken frångick sina föregångares traditionella, imiterande framställning och begränsade motivkrets. Den övergripande frågan i avhandlingen är: varför målade JohanThe aim of this dissertation is to find relationships between folk art, an artist's personal life and influential factors originating in the context. Christmas wall hangings by the peasant painter Johannes Nilsson (1757­1827) are the focus of the study. The fact that he had a special approach to the painting tradition raises two questions: Why did he paint the way he did? How can his hangings be i

Popular Abstract in Swedish Huvud- hals cancer Studier kring betydelsen av kärltäthet, svar på strålbehandling och tumörmetabolism, undersökt med positron emissions tomografi ( PET) Bakgrund Cancer i huvud-hals området är ovanligt i Sverige och utgör c:a 2,5% av alla nya cancerfall (40 000) per år. Beteckningen är ett samlingsnamn för tumörer med sinsemellan skilda egenskaper, uppkomna från i förTreatment options of head and neck squamous cell carcinoma (HNSCC) usually include combinations of radiotherapy and surgery, and in some cases addition of chemotherapy. In locally advanced cases cure rates are low. Current prognostic factors cannot foresee the outcome for the individual patient. There is consequently a need for reliable prognostic and predictive factors. Through identification of