Filetype
Altering the fate of newborn cells in the hippocampus after status epilepticus Epilepsy is a common neurological disorder that is estimated to affect approximately 50 million people around the world according to the World Health Organization. This disorder is characterized by an increase in the predisposition to generate seizures, which are periods of hyperexcitable neuronal signaling. The treatm
Popular Abstract in English Huntingtons sjukdom (HS), även kallad danssjukan, är en ärftlig och dödlig sjukdom som leder till ofrivilliga motoriska rörelser. Personer med HS får vanligtvis symtom i medelål- dern och avlider efter 15–20 år. Diagnosen ställs klinisk när de första ofrivilliga rörelserna uppträder. Dessa symtom kan kopplas till celldöd i de delar av hjärna som styr vår rörelse. SjukdoHuntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of the CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances and metabolic dysfunction are also part of the disease manifestation. These symptoms often precede the motor symptoms by decades. The hypothalamus is an area in the brain involved in the regulation of emotions and m
The major histocompatibility class I (MHC-I) genes are highly polymorphic and the proteins that they encode play a crucial role in both the innate and the adaptive immune response. A MHC-I molecule consists of three parts, one polymorphic heavy chain, one invariant light chain, β2-microglobulin and a peptide of usually between 8-11 amino acids in length. The maturation and quality control of MHC-I
Abstract COPD is a major cause of chronic morbidity and mortality throughout the world. It is a preventable and treatable disease. Smoking is the most commonly encountered risk factor for COPD and the habit now unfortunately starts at earlier ages than before. There is a strong necessity to diagnose COPD in early stages before symptoms present themselves. MRI with hyperpolarized 3He using diffusio
In the US and most European countries, testicular cancer is the most common malignancy in young men aged 20-40 years. Since the introduction of cisplatin-based treatment in the 1970s, more than 95% of the patients are cured. The increasing incidence of testicular cancer and high survival rates, has led to a growing number of testicular cancer survivors (TCSs). As they have a long life expectancy i
Popular Abstract in Swedish Framtida klimatförändringar påverkas till stor del på människans utsläpp av CO2, samt av klimat- och CO2-relaterade återkopplingar genom kolcykeln i både landbaserade ekosystem och hav. Landbaserade ekosystem tar för tillfället upp omkring 25% av de antropogena utsläppen av CO2 från förbränning av fossila bränslen och markanvändning, men att tillskriva vilka mekanismer The nature of future climate change will depend on anthropogenic emissions of CO2, as well as climate- and CO2-mediated feedbacks through carbon (C) cycling in both terrestrial ecosystems and oceans. Terrestrial ecosystems remove presently about 25% of the anthropogenic CO2 fossil-fuel and land-use change emissions, but to attribute which mechanisms cause this uptake, and the key regions where it
Popular Abstract in English We won’t give up Anatolia! Shouting this slogan, thousands of villagers marched towards Ankara, protesting against the projects that threaten to channel Anatolian rivers into hydro-power plants. The majority of demonstrators did not reach Ankara. The police stopped them at the city gates for disturbing the public order: hydroelectricity development is a national prioritPrivate Rivers is a study of contested processes whereby use rights to water are privatised for electricity production. It engages with the issues of renewable energy solutions and the sustainability of run-of-river hydro projects in Turkey by investigating the connection between these policies and justice for rural populations, whose livelihood depends on the rivers. Since 2001, water privatisati
Popular Abstract in Swedish Det övergripande syftet för den här avhandlingen var att identifiera miljöfaktorer som påverkar barn med ADHD, autism och Downs syndrom och deras förmåga att koncentrera sig i sin lärmiljö i skolan. Målet med den forskning som gjorts här är inte att avskriva några av de extraresurser som barnen ifråga behöver, utan i stället att ge förslag på hur man kan utforma deras lThe overall aim of this thesis was to identify environmental factors that affect children with ADHD, autism, and Down's syndrome and their ability to concentrate in their learning environment at school. The issue of this research is not to dismiss any of the additional resources these children are in need of; instead it is to suggest how to arrange learning environments in the most supportive way
Today wind power developers are exploring the possibilities of establishing wind turbines in forest areas, therefore improved sound prediction models for complex terrains are valuable. The Swedish model used today is only applicable for hard flat ground without any vegetation, and is not adjustable to any meteorological parameters except the wind speed. The companies DELTA, DONG Energy and EMD Int
This thesis approaches a field in refugee law, which is rather untouched by the researching community so far. The specific procedure scrutinised is the procedure allowing for asylum applications to be submitted at EU Member States' diplomatic and consular representations abroad. In the thesis this procedure goes under the name externalised processing. The specific aspect focused on is the poss
Most bilateral tax treaties contain provisions with the objective of preventing different types of treaty abuse. Limitation on benefits clauses are an example of such provisions, and are generally found in United States tax treaties. These include various tests, which need to be fulfilled by a taxpayer wishing to enjoy the benefits of a tax treaty. Most of the United States tax treaties with EU Me
Uppsatsens syfte är att utreda vilka möjligheter det finns att ingå ett avtal trots parts passivitet. Begreppet passivitet används i betydelsen underlåtenhet att agera när part, under en process till synes syftande till att avtal ska ingås, normalt kan förväntas agera genom en positiv viljeförklaring, ett nekande eller ett förtydligande. Innan passivitetsfrågan behandlas närmare presenteras den The purpose of this essay is to investigate the possibilities of entering into a binding agreement despite the passivity of one of the parties. The term passivity is used to denote the lack of action when a party, during a process with the apparent aim of entering into an agreement, typically can be expected to act through a declaration of intent, a refusal or a clarification. Before a closer en
The main purpose of the present work is to increase knowledge of in-plane tension behav-iour of masonry and develop a model able to describe the impact of parameters influencing cracking caused by restrained shrinkage. In the process the mechanism of load transfer between units and mortar joints is described. The influence of cohesion between units and mortar joints, unit and joint geometry and ex
Popular Abstract in Swedish Njurfunktion inom hjärtkirurgi Akut njursvikt (AKI) efter hjärtkirurgi är en allvarlig komplikation som förekommer i 25-35 % av alla patientfall. AKI medför förhöjd risk för allvarliga komplikationer och död efter hjärtkirurgi. Ett stort fokus ligger på detektion, prevention och behandling av AKI och forskningsfältet uppdateras kontinuerligt. En rad olika läkemedel har Abstract Acute kidney injury (AKI) is a common and serious complication after cardiothoracic surgery and is associated with increased short- and long-term mortality risk. Despite extensive studies in the field, a comprehensive understanding of this syndrome has remained elusive, partly due to divergent definitions of AKI and partly due to the limitations of available routine biomarkers to predict,
Timber structures and wooden element are in general affected by moisture and moisture variation in different ways. Their hygroscopic properties result in adsorption of water when wetted and in desorption when dried. Because the volume of wood is not constant but varies with the moisture content, uneven distribution of moisture will result in induced eigen-stresses because of internal restraint hyg
