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Prenatal Diagnosis of Haemophilia - psychological, social and ethical aspects

Popular Abstract in Swedish Hemofili (blödarsjuka) A och B, är X-kromosomalt, recessivt, nedärvda sjukdomar som orsakas av brist på eller avsaknad av koagulationsfaktor VIII respektive IX i blodet (FVIII och FIX). Sjukdomen drabbar män och överförs till nästa generation av kvinnliga bärare, som vanligtvis inte själva har några blödnings-symtom. Blödarsjuka ger redan tidigt i livet upphov till blöd

Modulation of Autoimmunity by Linomide treatment or interference with costimulation

Popular Abstract in Swedish Immunologi står för läran om immunförsvaret. Under evolutionens gång har vårt immunförsvar utvecklats med oss, och skyddar oss effektivt mot många olika virus, bakterier, parasiter och oönskade främmande ämnen. Hos ryggradsdjuren har immunförsvaret utvecklats till ett komplext system där flera olika specialiserade celler och molekyler samverkar för att uppnå ett optimal

Induction of operational tolerance to allografts and xenografts

Popular Abstract in Swedish Med dagens medicinska teknik måste mottagare av transplanterade organ ta immundämpande läkemedel varje dag för att undvika att transplantatet avstöts. Dessa patienter får ett generellt nedsatt immunförsvar vilket betyder att de blir mottagliga för infektionssjukdomar, samt har en ökad risk för att utveckla tumörer. När det gäller transplantation av vävnader från andra aInhibition of the costimulatory molecules B7 and CD40L with CTLA4Ig and anti-CD40L administered only during the first week after transplantation induces indefinite survival of allo- and xenogeneic heart transplants and significantly prolongs skin grafts in C3H mice. However, this treatment protocol is not as effective in C57BL/6 mice which reject skin transplants with nearly the same median surviv

Concurrent Development of Product and Packaging - Towards an Integrated Development Procedure

The global company operates from a number of locations worldwide, which entails geographical distances and logistical implications for product and parts transported, as well as the choice of product variety because of numerable worldwide consumer preferences. In these companies, packaging becomes a frequently used object to complement product features and achieve an effective and efficient means o

Human Endogenous Retroviruses: Studies on Transcriptional Activity and Genetic Variability.

Popular Abstract in Swedish Retrovirus är en stor grupp av virus som infekterar djur och människor och kan ge upphov till olika slags sjukdomar. Hos människa finns tre olika grupper av retrovirus. Det mest kända är HIV (humant immunbrist virus) och infektion av detta leder i många fall till AIDS. Andra mänskliga retrovirus är HTLV, humant T-cells leukemi virus, och humant spumavirus. Förutom dessa

Costs and benefits of immune system activation on physiology, behavior and offspring phenotype from an immunoecological perspective

Popular Abstract in Swedish Djur och människor exponeras hela tiden för virus, bakterier och andra parasiter. Många av dessa virus och bakterier är ofarliga, medan andra orsakar infektioner och gör oss sjuka. När ett djur smittas av t.ex. ett virus eller en bakterie som orsakar en infektion börjar deras immunförsvar direkt arbetet med att bli av med infektionen. Den första reaktionen som följer påPathogen challenges and host immune defenses can have substantial impact on life history patterns of animals. Biotic and abiotic factors may affect immunity in wild animals, influencing e.g., population dynamics and sexual selection. The overall aim of this thesis was to assess costs and benefits of immune system activation on physiology, behavior and offspring phenotype. The conducted research ha

An Experimental Study of Heat Transfer and Pressure Drop on the Bend Surface of a U-duct

This work concerns an experimental study of pressure drop and heat transfer for turbulent flow inside a U-duct. Such duct geometries can be found in many engineering applications where cooling air extracts heat from hot internal walls of the duct, e.g., passage cooling inside gas turbine blades. Both friction factors and convective heat transfer coefficients were measured inside a U-duct for three

The Molecular Chaperone DNAJB6 - A Suppressor of Disease Related Amyloid Fibril Formation

Popular Abstract in Swedish Proteiner är en av kroppens viktigaste beståndsdelar. Proteiner bygger upp stabila nätverk för att cellerna ska ha sin rätta form, de transporterar in vatten, salt och andra molekyler in i cellerna så att vi kan ta upp näring och de katalyserar kemiska reaktioner. Proteiner är uppbyggda av aminosyror som binds ihop till en kedja och som sedan veckar ihop sig så att protSeveral neurodegenerative diseases are caused by peptides or proteins forming amyloid fibrils such as the Aβ peptide involved in Alzheimer’s disease and the huntingtin exon-1 with a prolonged polyglutamine (polyQ) stretch involved in Huntington’s disease. The ability to form amyloid fibrils is an intrinsic feature in all proteins. The fibrils are built up of monomers to form elongated structures w

Serum antibodies to human papillomavirus (HPV) pseudovirions correlate with natural infection for 13 genital HPV types.

BACKGROUND: Serology for human papillomaviruses (HPV) types -16 and -18 is established as an important tool for studies of HPV vaccinology and epidemiology. However, as there are a large number of oncogenic genital types of HPV there is a need for development of high-throughput, validated HPV serological assays that can be used for more comprehensive seroepidemiological studies and for research on

Inverse modelling of European N2O emissions: assimilating observations from different networks

We describe the setup and first results of an inverse modelling system for atmospheric N2O, based on a four-dimensional variational (4DVAR) technique and the atmospheric transport zoom model TM5. We focus in this study on the European domain, utilizing a comprehensive set of quasi-continuous measurements over Europe, complemented by N2O measurements from the Earth System Research Laboratory of the

One man, 73 years, and 25 species. Evaluating phenological responses using a lifelong study of first flowering dates.

Phenological shifts linked to global warming reflect the ability of organisms to track changing climatic conditions. However, different organisms track global warming differently and there is an increasing interest in the link between phenological traits and plant abundance and distribution. Long-term data sets are often used to estimate phenological traits to climate change, but so far little has

Drought impact on forest carbon dynamics and fluxes in Amazonia

In 2005 and 2010 the Amazon basin experienced two strong droughts', driven by shifts in the tropical hydrological regime(2) possibly associated with global climate change(3), as predicted by some global models'. Tree mortality increased after the 2005 drought(4), and regional atmospheric inversion modelling showed basin-wide decreases in CO2 uptake in 2010 compared with 2011 (ref. 5). But the resp

Comparison of Methods to Obtain Force-Field Parameters for Metal Sites

We have critically examined and compared various ways to obtain standard harmonic molecular mechanics (MM) force-field parameters for metal sites in proteins, using the 12 most common Zn2+ sites as test cases. We show that the parametrization of metal sites is hard to treat with automatic methods. The choice of method is a compromise between speed and accuracy and therefore depends on the intended