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A dynamic mutational landscape associated with an inter-regionally diverse immune response in malignant rhabdoid tumour
Enhancing mitochondrial function in vivo rescues MDS-like anemia induced by pRb deficiency
Association between human papillomavirus status and health-related quality of life in oropharyngeal and oral cavity cancer survivors
Coral calcification responses to the North Atlantic Oscillation and coral bleaching in Bermuda
Reversible PCET and Ambient Catalytic Oxidative Alcohol Dehydrogenation by {V=O} Perfluoropinacolate Complexes
A low inflammatory, Langerhans cell-targeted microprojection patch to deliver ovalbumin to the epidermis of mouse skin
In a low inflammatory skin environment, Langerhans cells (LCs)– but not dermal dendritic cells (dDCs)– contribute to the pivotal process of tolerance induction. Thus LCs are a target for specific-tolerance therapies. LCs reside just below the stratum corneum, within the skin's viable epidermis. One way to precisely deliver immunotherapies to LCs while remaining minimally invasive is with a skin de
Distribution of erosions in hands and feet at the time for the diagnosis of RA and during 8-year follow-up
Background: Joint destruction in rheumatoid arthritis (RA) is usually evaluated by radiographs of both hands and feet, while the inflammatory status mostly is evaluated by DAS28 which, however, does not include the feet. Objectives: To investigate the distribution of erosions in hands and feet in early RA over 8 years and its potential clinical implications. Furthermore, the group of patients neve
Modelling feedbacks between human and natural processes in the land system
The unprecedented use of Earth's resources by humans, in combination with increasing natural variability in natural processes over the past century, is affecting the evolution of the Earth system. To better understand natural processes and their potential future trajectories requires improved integration with and quantification of human processes. Similarly, to mitigate risk and facilitate socio-e
Neuropeptide Y, peptide YY and C-terminal fragments release histamine from rat peritoneal mast cells
1. Neuropeptide Y (NPY) and peptide YY (PYY) seem to act on at least two receptor subtypes, Y1 and Y2. The Y1-receptor requires the whole C-terminally amidated NPY/PYY molecule whereas the Y2-receptor in addition recognizes C-terminal fragments of the two peptides. The present study was designed to elucidate whether NPY and related peptides were able to release histamine from isolated peritoneal m
Estrogen receptor alpha gene polymorphisms and bone mineral density : haplotype analysis in women from the United Kingdom
Cadmium, carotid atherosclerosis, and incidence of ischemic stroke
No implant migration and good subjective outcome of a novel customized femoral resurfacing metal implant for focal chondral lesions
Novel host defence mechanisms during bacterial infections
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool
MutT homologue 1 (MTH1) removes oxidized nucleotides from the nucleotide pool and thereby prevents their incorporation into the genome and thereby reduces genotoxicity. We previously reported that MTH1 is an efficient catalyst of O6-methyl-dGTP hydrolysis suggesting that MTH1 may also sanitize the nucleotide pool from other methylated nucleotides. We here show that MTH1 efficiently catalyzes the h
Short-term effects of follicle-stimulating hormone on immune function, lipid, and vitamin metabolism in transiently castrated men
Milling induced amorphisation and recrystallization of α-lactose monohydrate
Preprocessing of pharmaceutical powders is a common procedure to condition the materials for a better manufacturing performance. However, such operations may induce undesired material properties modifications when conditioning particle size through milling, for example. Modification of both surface and bulk material structure will change the material properties, thus affecting the processability o