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The Mini-Organo : A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development

Background: The use of in vitro cell cultures is a powerful tool for obtaining key insights into the behaviour and response of cells to interventions in normal and disease situations. Unlike in vivo settings, in vitro experiments allow a fine-tuned control of a range of microenvironmental elements independently within an isolated setting. The recent expansion in the use of three-dimensional (3D) i

Quantifying the quality of medical x-ray images. An evaluation based on normal anatomy for lumbar spine and chest radiography.

Popular Abstract in Swedish Det är sedan länge känt att för samma bildkvalitet kan patientstråldosen variera kraftigt mellan två olika sjukhus för en och samma röntgenundersökning. Det finns ett stort utrymme för sänkning av patientstråldosen utan att undersökningens kvalitet påverkas. Vid optimering inom röntgendiagnostik balanseras patientstråldos mot bildkvalitet. Optimeringen kräver att man haOptimisation in diagnostic radiology requires accurate methods for determination of patient absorbed dose and clinical image quality. Simple methods for evaluation of clinical image quality are at present scarce and this project aims at developing such methods. Two methods are used and further developed; fulfilment of image criteria (IC) and visual grading analysis (VGA). Clinical image quality de

New contact allergens are formed during vulcanization of rubber

In rubber materials, both natural rubber and synthetic rubber, several different contact allergenic chemicals are added to the batch before vulcanization. These compounds are relevant for investigation of rubber allergy of workers in rubber factories. The number of workers in the rubber industry has declined, owing to increased automation of the process; however, the number of users of rubber prod

Otillåten andrahandsuthyrning och oskälig andrahandshyra - En analys av gällande respektive föreslagen lagstiftning

Otillåten andrahandsuthyrning och oskäliga andrahandshyror är ett omfattande problem i Sverige. Förstahandshyresgäster upplåter sina lägenheter utan tillstånd och tar ut alldeles för höga hyror. Problemet har uppmärksammats av Justitiedepartementet, som i februari 2017 tillsatte en utredningskommitté med uppdraget att se över om gällande hyreslagstiftning kräver ändringar för att motverka uttag avUnlawful subletting and unjustifiable rents are widespread problems in Sweden. Tenants sublet their rental apartments without landlords’ permission and charge subtenants too high rental levels. The issue has drawn the attention of the Swedish Ministry of Justice, which in February 2017 appointed a committee to investigate whether decreasing unlawful subletting motivated by lucrative profits requir

Psychometric Evaluation of the Patient Experience Colonoscopy Scale

Rationale, Aims and Objectives: Colonoscopy, though common, can be uncomfortable, necessitating routine assessment of patient experience per European guidelines. Positive patient experiences are crucial as they influence willingness for repeat procedures. Patient-reported experience measures (PREMs) effectively capture patient perspectives through surveys, empowering patients to influence healthca

Integrating timescales with time-transfer functions: A practical approach for an INTIMATE database

The purpose of the INTIMATE project is to integrate palaeo-climate information from terrestrial, ice and marine records so that the timing of environmental response to climate forcing can be compared in both space and time. One of the key difficulties in doing this is the range of different methods of dating that can be used across different disciplines. For this reason, one of the main outputs of

OS089. Elevated levels of the heme scavenger alpha-1-microglobulin in maternal plasma at the end of first trimester in patients who subsequently develop preeclampsia

INTRODUCTION: Resent research has revealed an increased concentration of free fetal hemoglobin (HbF) in maternal serum from patients who subsequently develops preeclampsia (PE). In a previous study of 96 patients we have shown that HbF in combination with the heme-scavenger alpha-1-microglobulin (A1M) are potential predictive biomarkers of PE.OBJECTIVES: In this validating case-control study we ai