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We showed earlier that over-expression of protein kinase C (PKC) epsilon induces neurite outgrowth. The effect is mediated by a region (PKC epsilon PSC1V3) encompassing the pseudosubstrate, the two C1 domains and part of the V3 region, and is independent of the catalytic activity of the enzyme. In this region, residues immediately N-terminal of the C1b domain are crucial for neurite outgrowth. How

Popular Abstract in Swedish Konstant produktion av blodceller i benmärgen krävs för att bibehålla normal syretransport i blodet, sårläkning och ett effektivt immunförsvar. Bakom denna produktion ligger hematopoetiska blodstamceller som regleras av en komplex interaktion mellan dem och deras omgivning. Varje blodstamcell kan med självförnyande celldelningar, där minst en dottercell bibehåller en stHematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. Such slow kinetics during cell division might reflect a

Popular Abstract in Swedish Vad säger notbilden? Notation är av central betydelse i västerländsk tonal musik. Repertoarens utsträckning över flera århundraden gör det angeläget att studera hur musikaliskt innehåll medieras genom notation. I denna studie har strategiskt utvalda musikers sätt att ta sig an noterna till tonal musik undersökts. Slutsatser har dragits beträffande notbildens funktionerAbstract Centering on notation is a characteristic of Western tonal music. The printed scores are expected to provide the necessary information on musical expression. In this study, strategically selected contemporary musicians’ ways of under-standing the printed scores are investigated. All participants are thoroughly familiar with musical practice in Western tonal tradition. The intention is to

This study describes the integrated sympathetic/metabolic control of capillary pressure (Pc) and filtration in cat skeletal muscle as studied during graded exercise and superimposed graded (2, 6 and 16 Hz) vasoconstrictor nerve excitation. The applied technique permitted simultaneous analysis of the underlying changes of resistance in the whole vascular bed (RT) and in its large-bore arterial resi

In the lower siliceous uplands of Central Europe, various types of nutrient-poor grasslands are widespread and grow intermingled. These species-rich grasslands, often dominated by taxa of the Festuca ovina aggregate, comprise various phytosociological classes. They are remnants of a historic rural landscape and are of conservation importance. Few studies on such grasslands are available and there