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Pure cGMP-inhibited cAMP phosphodiesterase (cGI-PDE) in micrograms quantities was isolated from bovine aortic smooth muscle after more than 5000-fold purification using DEAE ion-exchange and affinity chromatography with a derivative of the specific cGI-PDE inhibitor cilostamide conjugated as a ligand to aminoethyl agarose (CIT-agarose). The cGI-PDE, which constituted about half of the high affinit

Background. An altered renal function is an essential component of the patho-physiology of pre-eclampsia. The plasma levels of low molecular mass proteins, e. g. beta-trace protein, beta-2-microglobulin and cystatin C, are increased in the third trimester of normal pregnancy. The plasma levels of cystatin C and beta-2-microglobulin are further increased in preeclampsia, and the cystatin C level ha

Popular Abstract in Swedish Den övergripande målsättningen med denna avhandling har varit att undersöka molekylära förändringar i icke läkande venösa bensår. Framförallt har fokus lagts på faktorer som underhåller den ständigt pågående inflammationen i venösa sår. Med tanke på att alla venösa sår alltid koloniseras av olika bakterier, har vi undersökt hur bakterier kan påverka sårläkning och infla

Popular Abstract in Swedish Satser i objektsposition i modern standardarabiska. MODERN STANDARDARABISKA Arabiska talas idag av ca 200 miljoner människor från Marocko och Mauretanien i väster till Irak och Oman i öster. De talade varianterna av språket skiljer sig åt ganska mycket, men man har ett gemensamt skriftspråk. Den moderna varianten av skriftspråket kallas ofta modern standardarabiska ocThis dissertation comprises a corpus-based study of the form and function of sentential object complements in Modern Standard Arabic (MSA). The study is motivated by the scarcity of investigations into MSA syntax as opposed to the syntax of Classical Arabic. Complements to three classes of complement-taking predicates (CTPs) ­ manipulation, cognition and utterance ­ are considered. The major part

Popular Abstract in Swedish En av hjärnans mest fascinerande egenskaper är dess förmåga att ständigt anpassa sig till nya utmaningar och förändringar i den yttre eller inre miljön. Denna formbarhet, eller plasticitet, sker på olika nivåer från små förändringar på molekylnivå till antalet av eller styrkan i förbindelser mellan nervceller och mängden transmittorsubstans de utsöndrar. De senaste dece

A generalized scattering matrix method is presented for spin-dependent electron transport in a quantum waveguide under the modulations of local magnetic field and/or spin-orbit interaction (SOI). All the required Hamiltonian matrices are expressed in terms of a common basis spanned by the products of the transverse spatial eigenstates and the spin eigenstates of the leads. In the formulation we ha

Popular Abstract in Swedish Framväxten av affärssystem under 1990 talet är en av de mest betydelsefulla utvecklingarna inom verksamhetsstödjande informationssystem. Affärssystem karaktäriseras av omfattande branschtäckning, stor funktionalitet, generisk lösning, processorientering, integrerad lösning och centralt dataformat, som tillsammans gör affärssystem kanske till den hittills mest komplexa oEnterprise Systems are one of the most important developments in corporate information systems during the last decade. These integrated information systems are characterized by a number of features which include a very broad scope and functionality, as well as being generic, master data, and business-process orientated. Together, these features make Enterprise Systems unique vis-à-vis other inform

Introduction: Acquired AmpC enzymes, classified as miscellaneous extended-spectrum beta-lactamase (ESBLM) enzymes according to a recently proposed beta-lactamase classification, are increasing according to several publications. Simple and rapid methods for detection of ESBLM are needed for appropriate infection control. A gel-based multiplex PCR method for acquired bla(AmpC) detection and subtype

Results of numerical simulations are presented for flow past a stationary circular cylinder at low Reynolds numbers (Re=50-200). The simulations were carried out using a finite-volume code employing a fractional step method with second-order accuracy in both space and time. A sensitivity study on numerical parameters concerning the domain size, grid independence and time step resolution was carrie

BACKGROUND: Serology for human papillomaviruses (HPV) types -16 and -18 is established as an important tool for studies of HPV vaccinology and epidemiology. However, as there are a large number of oncogenic genital types of HPV there is a need for development of high-throughput, validated HPV serological assays that can be used for more comprehensive seroepidemiological studies and for research on

4MOST is a wide-field, high-multiplex spectroscopic survey facility under development for the VISTA telescope of the European Southern Observatory (ESO). Its main science drivers are in the fields of galactic archeology, high-energy physics, galaxy evolution and cosmology. 4MOST will in particular provide the spectroscopic complements to the large area surveys coming from space missions like Gaia,