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Popular Abstract in Swedish Med modern mätteknik kan vi mäta cellers egenskaper för alla gener samtidigt. För att tolka den stora datamängden krävs analysmetoder och datorverktyg. Den här avhandlingen behandlar ett antal sådana verktyg avsedda att klargöra geners och proteiners inbördes samband. En metod att hantera datavärden av varierande kvalité presenteras, såväl som ett verktyg att visualiserWith the great progress of technology in genomics and proteomics generating an exponentially increasing amount of data, computational and statistical methods have become indispensable) for accurate biological conclusions. In this doctoral dissertation, we present several algorithms designed to delve large amounts of data and bolster the understanding of molecular biology. MAPK and PI3K, two signal

I det generella begreppet våldtäkt har våld inbegripits som en självklar omständighet i många hundra år. Det har även varit ett krav i lagstiftning. I dagens sexualbrottslagstiftning är det inte längre ett krav. En våldtäkt kan begås på internet genom medgärningsmannaskap eller om det med hänsyn till kränkningens allvar är att jämföra med samlag. Av media framkommer det att detta är något unikt fö

This dissertation deals with antique warfare in general and late Roman warfare in particular. The overall aim is to discuss the concept of strategy in the archaeological and historical reconstruction, based on Edward N. Luttwak’s groundbreaking work The Grand Strategy of the Roman Empire (1976). Luttwak’s influence on various provincial Roman research fields cannot be underestimated, but the book

We prove the existence of the old and metal-rich moving group HR 1614. This is done using the new Hipparcos parallaxes in combination with metallicities derived from Strömgren photometry, supported by dynamical simulations of the evolution of old moving groups in the galactic potential. A new selection criterion for this moving group is presented as well as a new, extended sample of probable membe

The study of exoplanets and especially their atmospheres can reveal key insights on their evolution by identifying specific atmospheric species. For such atmospheric investigations, high-resolution transmission spectroscopy has shown great success, especially for Jupiter-type planets. Towards the atmospheric characterization of smaller planets, the super-Earth exoplanet 55 Cnc e is one of the most

Investigating the chemical homogeneity of stars born from the same molecular cloud at virtually the same time is very important for our understanding of the chemical enrichment of the interstellar medium and with it the chemical evolution of the Galaxy. One major cause of inhomogeneities in the abundances of open clusters is stellar evolution of the cluster members. In this work, we investigate va

The conversion factor αCO from the observable CO(1-0) luminosity to the mass of molecular gas is known to vary between isolated galaxies and some mergers, but the underlying reasons are not clearly understood. Thus, the value(s) of αCO that are to be adopted remain highly uncertain. To provide better constraints, we applied the large velocity gradient method to a series of hydrodynamical simulatio

The Gaia-ESO Survey (GES) observed many open clusters as part of its programme to spectroscopically characterize the various Milky Way populations. GES spectroscopy and Gaia astrometry from its second data release are used here to assign membership probabilities to targets towards 32 open clusters with ages from 1 to 3800 Myr, based on maximum likelihood modelling of the 3D kinematics of the clust

A novel approach is developed for predicting body trajectories for cancer progression, where conditional probabilities of clinical data are modeled using Hidden Markov Model techniques. Basically, each potential body site is encoded by an N-letter code, and a disease trajectory is described in terms of a string of letters. Patient data base records are then represented by such strings with differe

We present a simple, semi--analytical description for the final stagesof mergers of black hole (BH) -- neutron star (NS) systems. Such systemsare of much interest as gravitational wave sources and gamma--ray burstprogenitors. Numerical studies show that in general the neutron star isnot disrupted at the first phase of mass transfer. Instead, what remainsof the neutron star is left on a wider, ecce

We report on a search for gravitational waves from coalescing compact binaries using LIGO and Virgo observations between July 7, 2009, and October 20, 2010. We searched for signals from binaries with total mass between 2 and 25M(circle dot); this includes binary neutron stars, binary black holes, and binaries consisting of a black hole and neutron star. The detectors were sensitive to systems up t

This paper presents results of an all-sky search for periodic gravitational waves in the frequency range [50, 1190] Hz and with frequency derivative range of similar to[-20, 1.1] x 10(-10) Hz s(-1) for the fifth LIGO science run (S5). The search uses a noncoherent Hough-transform method to combine the information from coherent searches on time scales of about one day. Because these searches are ve

We present high spectral resolution (similar to 3 km s(-1)) observations of the nu(2) ro-vibrational band of H2O in the 6.086-6.135 mu m range toward the massive protostar AFGL 2591 using the Echelon-Cross-Echelle Spectrograph (EXES) on the Stratospheric Observatory for Infrared Astronomy (SOFIA). Ten absorption features are detected in total, with seven caused by transitions in the nu(2) band of

Context. New instrumental capabilities and the wealth of astrophysical information extractable from the near-infrared wavelength region have led to a growing interest in the field of high resolution spectroscopy at 1-5 mu m. Aims. We aim to provide a library of observed high-resolution and high signal-to-noise-ratio near-infrared spectra of stars of various types throughout the Hertzsprung-Russell

Starting in 2013, Gaia will deliver highly accurate astrometric data, which eventually will supersede most other stellar catalogues in accuracy and completeness. It is, however, limited to observations from magnitude 6 to 20 and will therefore not include the brightest stars. Nano-JASMINE, an ultrasmall Japanese astrometry satellite, will observe these bright stars, but with much lower accuracy. H

The current status of a real-time real-sky dual-conjugate adaptive optics experiment is presented. This experiment is a follow-up on a lab experiment at Lund Observatory that demonstrated dual-conjugate adaptive optics on a static atmosphere. The setup is to be placed at Lund Observatory. This means that the setup will be available 24h a day and does not have to share time with other instruments.

Spectroscopic radial velocities for several nearby open clusters suggestthat spectra of (especially earlier-type) rapidly rotating stars aresystematically blueshifted by 3 km s^-1 or more, relative tothe spectra of slowly rotating ones. Comparisons with astrometricallydetermined radial motions in the Hyades suggests this to be an absoluteblueshift, relative to wavelengths naively expecte