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The goal of this investigation is to study the performance of two different aspects of neural network ensembles: one ensemble contains over-trained networks and the other very many members. The over-training of the networks within the first ensemble is achieved with a larger number of hidden neurons than the approximation task in question would require. The result of the investigation is that over

Vetenskap inom planetformation a ̈r ett omr ̊ade som har utvecklats mycket sedan de allra fo ̈rsta exoplaneterna uppt ̈acktes. Da ̈r vi tidigare hade ett enda exemplar av planetsystem att studera (v ̊art egna Solsystem) har vi idag tusentals observationer av planetsystem runt andra stj ̈arnor. N ̊agot som f ̈orbryllade forskare d ̊a de fo ̈rsta uppt ̈ackterna gjordes ̈ar att exoplaneter, specifikt

When diagnosing acute coronary syndrome, time is of the essence and electrocardiography the most effective method to obtain data about the patients condition. Artificial neural networks can here be used to assist medical doctors. In this text the wavelet transform is introduced as a signal processing method for piping ECG-curves to ANN’s. The performance of this setup (ANN performance is measured b

Recent advances in live imaging and genetics of mammalian development which integrate observations of biochemical activity, cell-cell signaling and mechanical interactions between cells pave the way for predictive mathematical multi-scale modeling. In early mammalian embryo development, two of the most critical events which lead to tissue patterning involve changes in gene expression as well as me

The phytohormone auxin plays an essential role in many aspects of plant growth and development. Its patterning, intercellular transport, and means of signaling have been extensively studied both in experiments and computational models. Here, we present a review of models of auxin-regulated development in different plant tissues. This includes models of organ initiation in the shoot apical meristem

We discuss partially quenched chiral perturbation theory (PQ chi PT) and possible fitting strategies to lattice QCD data at next-to-next-to-leading order (NNLO) in the mesonic sector. We also present a complete calculation of the masses of the charged pseudoscalar mesons, in the supersymmetric formulation of PQ chi PT. Explicit analytical results are given for up to three nondegenerate sea-quark f

Recent experiments have identified peptides that adhere to GaAs and Si surfaces. Here, we use all-atom Monte Carlo simulations with implicit solvent to investigate the behavior in aqueous solution of four such peptides, all with 12 residues. At room temperature, we find that all four peptides are largely unstructured, which is consistent with experimental data. At the same time, we find that one o

We study the folding thermodynamics of a beta-hairpin and two three-stranded beta-sheet peptides using a simplified sequence-based all-atom model, in which folding is driven mainly by backbone hydrogen bonding and effective hydrophobic attraction. The native populations obtained for these three sequences are in good. agreement with experimental data. We also show that the apparent native populatio

In multicellular organisms cells grow, divide and adopt different fates, resulting in tissues and organs with specific functions. In recent years, a number of studies have brought quantitative knowledge about how these processes are orchestrated, shedding new light on cells as active and central players in morphogenesis. We explore recent advances in understanding plant morphogenesis from a quanti

Histological grade is one of the most commonly used prognostic factors for patients diagnosed with breast cancer. However, conventional grading has proven technically challenging, and up to 60% of the tumors are classified as histological grade 2, which represents a heterogeneous cohort less informative for clinical decision making. In an attempt to study and extend the molecular puzzle of histoloHistological grade is one of the most commonly used prognostic factors for patients diagnosed with breast cancer. However, conventional grading has proven technically challenging, and up to 60% of the tumors are classified as histological grade 2, which represents a heterogeneous cohort less informative for clinical decision making. In an attempt to study and extend the molecular puzzle of histolo

Estimation of the generalization performance for classification within the medical applications domain is always an important task. In this study we focus on artificial neural network ensembles as the machine learning technique. We present a numerical comparison between five common resampling techniques: k-fold cross validation (CV), holdout, using three cutoffs, and bootstrap using five different

Popular Abstract in English There is a continuous search for reliable, robust easy to use, portable and cost effective analytical tools with applications in food industry, biomedicine, environmental monitoring and homeland security. The main focus of the thesis was on the development of electrochemical (bio)sensors designed to detect analytes of key importance from biological matrixes (e.g., fermeThere is a continuous search for reliable, robust, easy to use, portable and cost effective analytical tools with applications in food industry, biomedicine, environmental monitoring and homeland security. The main focus of this thesis is the development of electrochemical (bio)sensors and bioanalysis systems (to be applied in two major fields of interest: food & beverage industry and biomedic

We employ a mesoscopic model for studying aggregation processes of proteinlike hydrophobic-polar heteropolymers. By means of multicanonical Monte Carlo computer simulations, we find strong indications that peptide aggregation is a phase separation process, in which the microcanonical entropy exhibits a convex intruder due to non-negligible surface effects of the small systems. We analyze thermodyn

An atomic protein model with a minimalistic potential is developed and then tested on an α-helix and a β-hairpin, using exactly the same parameters for both peptides. We find that melting curves for these sequences to a good approximation can be described by a simple two-state model, with parameters that are in reasonable quantitative agreement with experimental data. Despite the apparent two-stat

För att en gärning ska anses som brottslig i svensk rätt krävs att den begåtts uppsåtligen, om inte annat har angetts. Detta framgår av första kapitlet i BrB. Men det finns situationer då det inte är självklart att gärningsmannen agerat uppsåtligen. Exempel på dessa situationer är då personen i fråga drabbats av tillfällig sinnesförvirring alternativt lider av en allvarlig psykisk störning, kortvaUnless otherwise stated, an act shall be regarded as a crime only if it is committed intentionally. Otherwise it is not considered a crime in Swedish law according to the first chapter in the Swedish penal code. It does, however, occur circumstances where it is difficult to determine whether the perpetrator acted with intent. For example, there is an uncertainty in determining whether a person act

I denna uppsats analyserar jag den debatt som har förts i Sverige i frågan om normprövning – dvs. möjligheten att underkänna en norm med hänvisning till att den strider mot ett högre rättsbud – från 1828 till 1980. Jag utgår ifrån att normprövningsdebatten kan indelas i tre olika diskurser, som var och en utgör ett säreget sätt att argumentera i frågan. Jag försöker visa hur de olika diskurserna h

Mord är det allvarligaste av de grövsta brotten. Straffet för den som berövar en annan person livet har sedan brottsbalkens ikraftträdande år 1965 varit fängelse i 10 år eller på livstid. I syfte att skapa en mer nyanserad straffmätning för mord och en höjd straffnivå för de mord som ej föranleder fängelse på livstid infördes den 1 juli 2009 en utvidgad straffskala för mord, enligt vilken den som

Using kilometric arrays of air Cherenkov telescopes at short wavelengths, intensity interferometry may increase the spatial resolution achieved in optical astronomy by an order of magnitude, enabling images of rapidly rotating hot stars with structures in their circumstellar disks and winds, or mapping out patterns of nonradial pulsations across stellar surfaces. Intensity interferometry (once pio