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Backgound: In severe, medically unresponsive congenital hyperinsulinism (CHI), the histological differentiation of focal versus diffuse disease is vital, since the surgical management is completely different. Genetic analysis may help in the differential diagnosis, as focal CHI is associated with a paternal germline ABCC8 or KCNJ11 mutation and a focal loss of maternal chromosome 11p15, whereas a

Some products are considered to be 'bad taste' and therefore of less value. However, if we focus on what a product does to and for its users, rather than on what a product is, we can disregard superficial statements based on taste, and instead reach a better understanding of design. This reasoning is based on the relationship between 'good taste' and 'good design', terms which are sometimes confus

Phylogenetic analysis of glycoside hydrolase family 2 including Aspergillus sequences and characterised β-mannosidases from other organisms, clusters putative Aspergillus β-mannosidases in two distinct clades (A and B). Aspergillus species have at least one paralog in each of the two clades. It appears that clade A members are extracellular and clade B members intracellular. Substrate specificity

Abstract in UndeterminedPrevious research on antonyms has shown that some pairings form more felicitous couplings than others. Following up on that research, we conducted two semantic categorization experiments using Event Related Potentials to establish whether there are neurophysiological differences related to levels of antonym canonicity. In Experiment 1, the members of canonical antonym pairs

Peroxidase-like activity of Vitreoscilla hemoglobin (VHb) has been recently disclosed. To maximize such activity, two catalytically conserved residues (histidine and arginine) found in the distal pocket of peroxidases have successfully been introduced into that of the VHb. A 15-fold increase in catalytic constant (k(cat)) was obtained in P54R variant, which was presumably attributable to the lower

The use of dental implants to treat tooth loss has increased rapidly over recent years. 'Smooth' implants showing high long-term success rates have successively been replaced by implants with rougher surfaces, designed to stimulate rapid osseointegration and promote tissue healing. If exposed in the oral cavity, rougher surfaces may promote bacterial adhesion leading to formation of microbial biof

Using recently developed algorithms based on Cholesky decomposition of two-electron integrals to compute response properties at the correlated level, the static and dynamic (at 589 nm) polarizabilities of [4n + 2]-annulenes (n = 1, 2, 3, 4) have been calculated. The results show that the perpendicular component increases along the series linearly with the number of double bonds. The in-plane stati

The objectives of the present study were to estimate 10-year probabilities of clinical vertebral fractures in women, according to age and bone mineral assessment using phalangeal quantitative ultrasound (QUS). Risks were computed from UK derived data on the incidence of a first symptomatic vertebral fracture and mortality rates for each year of age using Poisson models. The 10-year probability of

The present study deals with free play in preeschool. The purpose is to investigate the way children conceptualize play, and the significance of play in preeschool activities. The latter has been illuminated through an analysis of normative documents, and vatious methods have been worked out that show how the possibilities of play can be made use in preschool. Group interviews with children betwee

Popular Abstract in Swedish Friction Stir Welding eller ”friktionsomrörningssvetsning” är en svetsprocess som kräver ett roterande verktyg som genom friktionsvärme får materialet att mjukna. Verktyget blandar runt det plastiska materialet mekaniskt och skapar en fog av hög kvalité. Processen fungerar utan gas, utan rök, utan tillsatsmaterial och utan att smälta materialet. Alla dessa fördelar skapFriction Stir Welding (FSW) is a modern welding process that joins materials by frictional heat, generated by a rotating tool. Unlike other welding processes, the material never melts, which is beneficial for the weld properties. FSW is already widely adopted in several industries but the applications are limited to simple geometries like straight lines or circular welds, mostly in aluminium. The

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Det sena 90-talets tre mest populära filmer, ”Jägarna” (1996), ”Fucking Åmål” (1998) och ”Hälsoresan” (1999) skildrade samtliga ett Sverige i ekonomiskt och moraliskt förfall, ett land genomsyrat av "onda" kollektiva mekanismer. Att den populära 90-talsfilmen skildrade vårt land i sådana termer kan rimligen ha att göra med att den ekonomiska tillbakagången i Sverige hade varit drastisk och att mån

In this paper I give a short presentation of a syntactic approach to argument structure, taking a particular implementation of the minimalist framework (Chomsky (1995, 2001 and later)) as my point of departure. The proposed account allows for only 16 different argument structures, thereby reducing the syntactic variation at this level of syntax considerably. The theory also offers an explanation w

Jane Eyre is perhaps the best known governess charatcer in nineteenth-century fiction, but as this article shows, Charlotte Brontë's heroine differs radically from the common depiction of governesses at the time. After an outline of the genre characteristics of the governess novel this article offers a close reading of some scenes in Jane Eyre in order to establish to what extent the novel can be

Behovet av ny kunskap i anslutning till klimatförändringen är enormt. Det behövs ny kunskap om hur • klimatet kan komma att utvecklas. • skogsekosystemet kan komma att utvecklas. • dessa system interagerar. Detta kunskapsuppbyggande är högst angeläget att påbörja men kommer att ta tid. Många beslut inom skogsbruket måste fattas redan idag utan tillgång till forskningsresultaten. Man tvingas alltså