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Estrogen and progesterone are key regulators of normal breast epithelial cell proliferation and differentiation. They are also involved in the initiation and progression of breast tumorigenesis. Several experimental studies have demonstrated that steroid hormones affect cell cycle proteins associated with tumor initiation and progression. Hormone replacement therapy (HT) is widely used to alleviat

This paper presents the main features of the TURNUS co-exploration environment, an unified design space exploration framework suitable for heterogeneous parallel systems designed using an high level dataflow representation. The main functions of this tool are illustrated through the analysis of a video decoder implemented in the RVC-CAL dataflow language.

To determine whether the Joint European Societies guidelines on cardiovascular prevention are being followed in everyday clinical practice of secondary prevention and to describe the lifestyle, risk factor and therapeutic management of coronary patients across Europe.

It is well known that user proximity introduces absorption and impedance mismatch losses that severely degrade multiple-input multiple-output (MIMO) performance of handset antennas. In this work, we experimentally verified the potential of adaptive impedance matching (AIM) to mitigate user interaction effects and identified the main AIM gain mechanism in realistic systems. A practical setup includ

While research on the design of heterogeneous concurrent systems has a long and rich history, a unified design methodology and tool support has not emerged so far, and thus the creation of such systems remains a difficult, time-consuming and error-prone process. The absence of principled support for system evaluation and optimization at high abstraction levels makes the quality of the resulting im

Protein structure-function relationships can be studied by using linker insertion mutagenesis, which efficiently identifies essential regions in target proteins. Bacteriophage Mu in vitro DNA transposition was used to generate an extensive library of pentapeptide insertion mutants within the alpha-complementing domain 1 of Escherichia coli beta-galactosidase, yielding mutants at 100% efficiency. E

Homogeneous charge compression ignition (HCCI) is a promising internal combustion engine concept. It holds promise of combining low emission levels with high efficiency. However, as ignition timing in HCCI operation lacks direct actuation and is highly sensitive to operating conditions and disturbances, robust closed-loop control is necessary. To facilitate control design and allow for porting of

Energy and power efficiency are becoming important topics within the graphics community. In this paper, we present a simple, straightforward method for measuring per-frame energy consumption of real-time graphics workloads. The method is non-invasive, meaning that source code is not needed, which makes it possible to measure on a much wider range of applications. We also discuss certain behaviors

“The implications and applications of biotechnology continue to be at the centre of public debate. In the light of rapid scientific advances and novel insights, the multi-faceted discussions are particularly fierce with regard to patents on DNA–related technology. In the often very emotionally-led debate basically two directly conflicting schools of thoughts can be identified. Some people believe

This paper presents a new approach to buffer dimensioning for dynamic dataflow implementations. A novel transformation applied to the execution trace graph of a dataflow program is introduced in order to generate an event driven system. It is shown how model predictive control theory techniques can be applied to such a system to analyse the execution space of a dataflow program and to define and t

Popular Abstract in Swedish Skogar är av stor betydelse ur klimatsynpunkt på grund av deras stora förmåga att binda kol. Skogar på de nordligare breddgraderna spelar en viktig roll med sitt stora kolupptag, men eftersom dessa nordliga skogar troligen kommer att påverkas av klimatförändringarna i hög grad är det osäkert hur framtida kolupptag kommer att utvecklas. Ett varmare klimat kommer sannolikForests are of major importance to climate change mitigation due to their strong capacity to sequester carbon. Nearly half of the terrestrial carbon is stored in forests, and forests contribute to half of the terrestrial primary productivity, with forests in the mid- and high latitude ecosystems as major contributors. These high latitude forests are, however, projected to be strongly influenced by

A common assumption in motion blur rendering is that the triangle vertices move in straight lines. In this paper, we focus on scenarios where this assumption is no longer valid, such as motion due to fast rotation and other non-linear characteristics. To that end, we present a higher-order representation of vertex motion based on Bézier curves, which allows for more complex motion paths, and we de

With the advent of IoT and the associated variety of pervasive and context-aware applications, there is an increasing requirement to support the execution of these applications on devices with limited processing power. This is a cost-intensive process as this usually requires the deployment of centralized computing infrastructure accessible via a cloud interface. We envision a distributed executio

This is a protocol for a Cochrane Review (Overview). The objectives are as follows: To summarize the evidence from systematic reviews regarding the effects and safety of pharmacological interventions related to pain and sedation management in order to prevent GMH-IVH in ventilated preterm infants.

Precise air-path control of heavy-duty diesel engines contributes to emission regulation and high engine efficiency. The air path with VGT and EGR system is highly nonlinear with non-minimum-phase-system properties. The authors present a nonlinear control design - Receding Horizon Sliding Control (RHSC) to solve the tracking problem of the air-path. This control method handles the nonlinear dynami

Laser based investigations were performed on a prototype 4th generation DLE (dry low emission) burner under atmospheric pressure conditions to study the effects of changing burner geometry on the flame. In a full burner configuration, a divergent conical section termed the Quarl is located after the burner exit for expanding the flow area and holding the flame. The planar laser-induced fluorescenc