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Hard tissues in biology are typically hierarchical composites. Osteoderms are mineralized dermal structures, widespread in lizards, in which a hyper-mineralized superficial layer, the capping tissue, has recently attracted attention for its unusual structural and mechanical features, with, e.g., moduli reaching those of enamel. Here, a comparative study of osteoderms from six lizard species whose
Research in computational mechanics is increasingly in search of methods that directly incorporate the information governed by data. Within these data-based methods, the data-driven mechanics approach seeks to replace conventional material models with discrete data sets. Offering immense potential in computational mechanics, where the simulation of complex mechanical systems is often challenging,
Response to androgen receptor signaling inhibitors (ARSI) varies widely in metastatic castration resistant prostate cancer (mCRPC). To improve treatment guidance, biomarkers are needed. We use whole-genomics (WGS; n = 155) with matching whole-transcriptomics (WTS; n = 113) from biopsies of ARSI-treated mCRPC patients for unbiased discovery of biomarkers and development of machine learning-based pr
Decarbonizing the existing building stock is essential, especially as buildings in the EU (85% built before 2000) account for a third of energy-related greenhouse gas emissions. This study examines adaptive reuse of underutilized structures as a sustainable alternative to demolition and new construction. It addresses the surplus of redundant buildings, driven partly by needs for heritage conservat
Introduction: It is well known that urinary tract infection (UTI) during pregnancy is associated with preterm birth, but information about the risk of preterm birth depending on gestational week of infection is sparingly described in the literature. Material and Methods: An observational study based on data from Swedish registers including women giving birth 2014–2020 (n = 684 595). Pregnant women
UNLABELLED: In prostate cancer, androgen receptor (AR)-targeting agents are very effective in various disease stages. However, therapy resistance inevitably occurs, and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed integrative multiomics analyses on tissues isolated before and after 3 months of AR-targeting enzalutamide monotherapy from patients with high
CONTEXT: People viewed as "overweight" or "obese" are vulnerable to weight-based discrimination, creating inequities and adverse health outcomes. Given the high rates of obesity recorded globally, studies documenting weight discrimination in multiple countries, and an absence of legislation to address this form of discrimination, research examining policy remedies across different countries is nee
Background The aim of this systematic review and meta-analysis was to examine autoantibody positive individuals and define: (a) the relative risk of rheumatoid arthritis (RA) compared with autoantibody negative individuals and (b) the cumulative incidence of RA over time, in different populations. Methods A systematic literature search was performed in August 2025. Retrospective case control studi
Introduction: Out-of-pocket (OOP) healthcare costs remain prohibitive in low-resource settings, often pushing families into poverty. Universal health coverage (UHC) goals emphasise protecting households from financial hardship due to medical expenses. Objectives: This study examines which socioeconomic and demographic factors predict the amount of free mental healthcare support received by applica
The potential to source thermal energy from buried infrastructure such as tunnels and metro stations may offer significant potential to reduce the carbon dioxide emissions of heating and cooling, and reduce the costs associated with dedicated drilling for traditional ground-sourced systems. However, this remains a niche approach with few commercial schemes globally, partly due to high initial cost
Rapid warming in the Arctic is transforming northern ecosystems and altering their role in the global carbon cycle. Rising temperatures are driving shifts in vegetation composition, phenology, and ecosystem functioning, including earlier growing seasons and the expansion of shrubs across tundra landscapes. These changes influence surface energy balance, carbon uptake, and climate feedbacks, yet su
We present the design and implementation of a portable transfer system equipped with an integrated electrochemical cell that enables the controlled transfer of samples between an electrochemical environment and an ultrahigh vacuum (UHV) system without air exposure. This setup allows for the preparation of well-defined model surfaces, their electrochemical modification, and subsequent structural an
AimThere is a need for updated reference intervals for iron status biomarkers during infancy. This study aimed to investigate reference interval trends and diurnal variation of iron, transferrin, and transferrin saturation in infants subjected to delayed cord clamping at birth (DCC).MethodsData analysis from population-based Swedish studies, including 362 term-born infants subjected to DCC ≥ 60 s.
Immersive visual environment can deceive our interoceptive perception of how we move relative to our environment. If the visual environment or a high reliance on vision produces straining work conditions, motion sickness or is associated with a medical disorder, the causes merit addressing. Therefore, the purpose of this study was to investigate whether postural control adapts to challenging visua
Incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs), are approved for the treatment of type 2 diabetes, obesity, and related conditions, and have demonstrated significant benefits for individuals with these conditions. However, in recent years, public interest and demand for GLP-1RAs-often driven by media, social media influencers, advertising, and public disco
High-resolution rainfall data are essential for various hydrological applications such as flood modeling, soil erosivity studies, and urban water management. However, the scarcity of subdaily data, particularly in remote regions, necessitates reliable disaggregation methods to derive finer temporal resolutions from daily rainfall records. This study introduces a novel hybrid approach combining the
Effective governance and management of ecosystem functions to promote human well-being and social equity require a clear understanding of supply and demand dynamics. While this is widely acknowledged in assessments of ecosystem services, it remains largely neglected for ecosystem disservices, despite many ecosystem functions generating both services (benefits) and disservices (costs) depending on
Occurring in 2015/16, the strong El Niño has been shown to significantly influence the pantropical carbon fluxes with multiple lines of evidence. However, a comprehensive understanding on the regional and vegetation-specific net ecosystem productivity (NEP) in response to this El Niño event and its recovery trajectories remain unclear. We revisited the controlling factors in the recovery of pantro
