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Two major trends on children's skills to comprehend metaphors have governed the literature on the subject: the literal stage hypothesis vs. the early birds hypothesis (Falkum, 2022). We aim to contribute to this debate by testing children's capability to comprehend novel metaphors ('X is a Y') in Spanish with a child-friendly, picture selection task, while also tracking their gaze. Further, given
Objectives: This is a protocol for a Cochrane Review (prototype). The objectives are as follows:. The aim of this scoping review is to map the quantitative literature about in-hospital motor interventions used to reduce neurodevelopmental impairment in preterm infants. We will collate information about the features, delivery mechanisms, objectives, providers, underlying theoretical frameworks, hyp
The durability of existing infrastructures is a worldwide challenge in structural engineering. Societal demands for reducing greenhouse gas emissions, coupled with the financial constraints faced by many countries, push infrastructure management companies and owners to extend the lifespan of existing structures. However, extending the lifespan comes with a set of problems related to safety and tim
The incidence of intracerebral hemorrhage (ICH) associated with oral anticoagulants (OAC) is about one in five cases of ICH and associated with severe clinical presentation, frequently rapid clinical deterioration, and 30-days mortality of app 50%. This narrative review gives an overview of presentation and acute treatment of OAC-ICH. Oral anticoagulants do not cause ICH but lead to prolongation o
Importance: Identifying anatomy causally involved in psychosis could inform therapeutic neuromodulation targets for schizophrenia. Objective: To assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit. Design, Setting, and Participants: This case-control study mapped functional connections of published cases of lesions causing secondary psychosis
Objective To explore teaching- and assessment-related factors that predict medical students' perceived attainment of sufficient skills to incorporate scientific evidence into patient care. Methods An anonymous questionnaire was distributed to final-semester students in six medical programs in Sweden. The students were asked to rate statements concerning the extent to which 11 national degree outco
The efficacy of cancer immunotherapy relies on the recruitment and activation of cytotoxic T cell responses against solid tumors by type 1 conventional dendritic cells (cDC1s). However, the generation of cDC1s for cancer immunotherapy faces significant limitations, including poor cell yield, functional heterogeneity, and susceptibility to immunosuppression in the tumor microenvironment (TME). We r
BACKGROUND: Neuromuscular exercise is commonly used in knee injury prevention programs and in rehabilitation following knee injury, and can also be used to address functional impairments is middle-aged and older individuals with knee and hip osteoarthritis (OA). CLINICAL QUESTION: What is neuromuscular exercise for OA? Why should clinicians use it? And how? Nine themes of common questions from exe
An approach to reducing greenhouse gas emissions that shows promise is the electrochemical conversion of CO2 to products with added value. Here, we present [Co(8HQ-Tpy)(H2O)]2 (PF6)2 ([Co1]), a cobalt-based molecular electrocatalyst that can convert CO2 to CO in a DMF/H2 O mixture (4.8 : 0.2 v/v) in a selective manner (8HQ-Tpy = 2-([2,2′:6′,2′′-terpyridin]-4′-yl)quinolin-8-ol). At an overpotential
What is the context?: Platelets contain three major types of granules (alpha granules, dense granules and lysosomal granules) that carry distinct cargo. Dense granules store small molecules such as calcium, serotonin and adenosine 5′-diphosphate (ADP) that are essential for platelet activation and aggregation. Impaired production or release of dense granules can affect blood clotting and cause inc
Microbial bio-aroma synthesized from biowaste, and its marketing is an emerging aspect of future research due to their benefits. However, the sensory lexicon of bio-aroma has not yet been developed so far. This study aims to identify the smell characteristics of bio-aroma produced by fermentative yeast Kluyveromyces marxianus by solid-state fermentation, where the sample was extracted from ferment
Hard tissues in biology are typically hierarchical composites. Osteoderms are mineralized dermal structures, widespread in lizards, in which a hyper-mineralized superficial layer, the capping tissue, has recently attracted attention for its unusual structural and mechanical features, with, e.g., moduli reaching those of enamel. Here, a comparative study of osteoderms from six lizard species whose
Research in computational mechanics is increasingly in search of methods that directly incorporate the information governed by data. Within these data-based methods, the data-driven mechanics approach seeks to replace conventional material models with discrete data sets. Offering immense potential in computational mechanics, where the simulation of complex mechanical systems is often challenging,
Response to androgen receptor signaling inhibitors (ARSI) varies widely in metastatic castration resistant prostate cancer (mCRPC). To improve treatment guidance, biomarkers are needed. We use whole-genomics (WGS; n = 155) with matching whole-transcriptomics (WTS; n = 113) from biopsies of ARSI-treated mCRPC patients for unbiased discovery of biomarkers and development of machine learning-based pr
Decarbonizing the existing building stock is essential, especially as buildings in the EU (85% built before 2000) account for a third of energy-related greenhouse gas emissions. This study examines adaptive reuse of underutilized structures as a sustainable alternative to demolition and new construction. It addresses the surplus of redundant buildings, driven partly by needs for heritage conservat
Introduction: It is well known that urinary tract infection (UTI) during pregnancy is associated with preterm birth, but information about the risk of preterm birth depending on gestational week of infection is sparingly described in the literature. Material and Methods: An observational study based on data from Swedish registers including women giving birth 2014–2020 (n = 684 595). Pregnant women
UNLABELLED: In prostate cancer, androgen receptor (AR)-targeting agents are very effective in various disease stages. However, therapy resistance inevitably occurs, and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed integrative multiomics analyses on tissues isolated before and after 3 months of AR-targeting enzalutamide monotherapy from patients with high
CONTEXT: People viewed as "overweight" or "obese" are vulnerable to weight-based discrimination, creating inequities and adverse health outcomes. Given the high rates of obesity recorded globally, studies documenting weight discrimination in multiple countries, and an absence of legislation to address this form of discrimination, research examining policy remedies across different countries is nee
