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α-Synuclein is a synaptic protein that accumulates primarily in synucleinopathies and secondarily in certain lysosomal storage disorders. However, its physiological roles in health and disease are not fully understood. In part, this has been hampered by the inability to visualize α-synuclein and its cellular localization, due to the lack of specific antibodies and faithful reporters. Here, we used

In recent decades, working with computers has evolved from a specialized area to a requirement at most workplaces. Information systems also change regularly and employees have to adapt to new computer systems. However all individuals do not like computer work and the concept of computer anxiety describes human attitudes to computers. This study examined how computer anxiety is influenced by an inf

The question of environmental protection has lately become essential due to the increased number of polluters and accidents that have occurred in recent decades. The starting point was the Torrey Canyon disaster which happened in March 1967 and exposed the entire international community to a great danger of environmental harm in general and marine pollution in particular. The accident also pointed

The increasingly competitive climate has caused companies to pursue counteractive strategies such as M&As in the hope to attain synergy potential. However, M&As are associated with a high failure rate and synergy realization is often unsuccessful. One area poorly covered in previous literature and often unattended by merging parties is synergies within logistics, despite its significance f

The purpose of this study was to examine the subjective experience of schizophrenia. Four people, two of them diagnosed with schizophrenia and two relatives, were interviewed. The themes selected were development of the disease, recovery, belief in the future, the role of families and siblings, stigmatization and the relationship between violent crimes and mental illness. The development and exper

This paper intends to investigate the impact of the two-sided market effect with nearby theories, the importance of customer loyalty and customer relationship management in the newspaper industry. It takes its theoretical references from academic research literature and interviews with the focus on customer loyalty and customer relationship management in the two-sided market environment. The resu

Almost 90% of the international trade is managed by ship, which has being dominated the international transportation over hundreds of years. The role of Documents in international trade, has turned the “money and goods” transaction into later “money and documents” transaction and in the process of improving international trade, a lot of by-products have formed at the mean time, one such being docu

The aim with this study was to investigate the senses of the lexemes /assassinated/, /killed/, and /murdered/ in 21st century American and British newspaper discourse, which was done with the method of corpus-driven Cognitive Linguistics. The main research questions dealt with how the combination of grammatical and contextual features of the articles frame patients and agents of the verbs. A focus

Förändring av individens anknytning till sociala nätverk kan vara ett sätt att få en tidigare kriminell och/eller missbrukare att värdera ett konformt liv. Detta med en förhoppning om att ersätta individens kriminella värden och attityder till konforma sådana, genom att individen associerar och identifierar sig med gruppen (det sociala nätverket). Med utgångspunkt i denna idé är därför vårt syfte

Att aktieägare skriver aktieägaravtal är vanligt förekommande i svenska aktiebolag och då framförallt i mindre, privata bolag. I aktieägaravtalet kan man avtala om bland annat rösträttsbegränsningar och ägarförhållanden. Den allmänna uppfattningen i Sverige har sedan länge varit att aktieägaravtal endast är obligationsrättsliga mellan avtalsparterna, och därmed aldrig kan binda aktiebolaget. Ett a

In the 1940-ies curtain walls were introduced, i.e. brick walls that do not have any bearing function but served as a front material. Horizontal reinforcement was used in this kind of walls, partly over and under openings or, in undisturbed wall fields, every 5-6th bed joint. In this work the tensile bond strength of mortar joints repaired with an injection tool and a manual method respectively is

Event är korta tidsintervall som skiljer längre episoder med stabila oceaniska förhållanden från varandra. När cirkulationen i världshaven tillfälligt stängs av under ett event förändras fauna- och bergartssammansättningen, och även isotopförhållandena. Målet med detta arbete har varit att utröna hur de sensiluriska brachiopoderna reagerade på det globalt kända Lau Event. På Gotland omfattar det lThe impact of the Ludfordian Lau Primo-Secundo Event on brachiopods from Gotland has been investigated. About 12 000 individuals were identified from five samples. The results are supplemented by an extensive literature study. On Gotland, the Lau Event spans the Botvide Mbr (uppermost När Fm, upper Hemse Group) and the Eke Fm. It caused extinctions, faunal, sedimentary and isotopic changes. Conodo

In the beginning of the 1990’s community service was introduced at a couple of Swedish courts as an experiment. It was to be a compliment to probation and together the two were supposed to be considered the equivalent in harshness of a shorter prison sentence. After a few years the experiment was extended to all Swedish courts and by the end of the decade community service was made a permanent par