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ype 2 diabetes (T2D) and obesity are multifactorial and polygenic metabolic diseases. Combinations of genetic and non-genetic risk factors such as risk SNPs, age, unhealthy diets, and physical inactivity increase the risk for these diseases. Emerging data also support a key role for epigenetic mechanisms in the pathogenesis of T2D and obesity. In this chapter, we summarize current knowledge of epi
The aluminum oxide-coating on cemented carbide tools used for metal cutting have been regarded as inert during cutting of steels. Because diffusional dissolution is not possible. Chemical degradation of aluminum oxide coatings is often overlooked, especially in the presence of ambient oxygen and non-metallic inclusions. High-pressure diffusion couples, advanced microscopy, and thermodynamics are u
Immigrant women in Sweden often have unmet sexual and reproductive health (SRH) needs. Successful contraceptive counselling may improve their sexual and reproductive health and rights. The unique Swedish model, with midwives as the main providers of contraceptive counselling, is important for immigrant women's health at both individual and societal levels. This study explored immigrant women's per
INTRODUCTION: Collagenous colitis (CC) is a common cause of chronic diarrhea and is characterized by a subepithelial thickened collagen layer in the colonic mucosa. It shares many of the characteristics found in autoimmune diseases, but no autoantibodies have been identified. In CC, an imbalance in collagen turnover is evident. The purpose of the present study was to investigate whether any collag
The cytokine TGFβ1 induces epidermal Langerhans cell (LC) differentiation from human precursors, an effect mediated through BMPR1a/ALK3 signaling, as revealed from ectopic expression and receptor inhibition studies. Whether TGFβ1‒BMPR1a signaling is required for LC differentiation in vivo remained incompletely understood. We found that TGFβ1-deficient mice show defective perinatal expansion and di
We present the direct stabilization of the CEP of a high-repetition rate OPCPA by employing a Stereo-ATI pulsemeter for single-shot detection and feedback to the oscillator at the full OPCPA repetition rate.
Current syntheses of CsPbBr3 halide perovskite nanocrystals (NCs) rely on overstoichiometric amounts of Pb2+ precursors, resulting in unreacted lead ions at the end of the process. In our synthesis scheme of CsPbBr3 NCs, we replaced excess Pb2+ with different exogenous metal cations (M) and investigated their effect on the synthesis products. These cations can be divided into two groups: group 1 d
Heterotopic ossification (HO) in tendons can lead to increased pain and poor tendon function. Although it is believed to share some characteristics with bone, the structural and elemental compositions of HO deposits have not been fully elucidated. This study utilizes a multimodal and multiscale approach for structural and elemental characterization of HO deposits in healing rat Achilles tendons at
Obesity is a complex and chronic disease affecting hundreds of millions of people worldwide and has reached epidemic proportions. It is important to understand the underlying mechanisms to tackle this devastating disease, thus preventing its comorbidities. The epigenome, including DNA methylation and histone modifications, appears to be the link between genetics and nongenetic factors, modulating
Background: In prostate cancer (PCa), questions remain on indications for prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging and PSMA radioligand therapy, integration of advanced imaging in nomogram-based decision-making, dosimetry, and development of new theranostic applications. Objective: We aimed to critically review developments in molecular hybrid imaging an
Objectives Construction workers are exposed to respirable dust, including respirable crystalline silica (RCS), which is a potential risk factor for cardiovascular disease (CVD). The aim of this study was to evaluate whether exposure to particles among construction workers is associated with short-and long-term alterations in CVD-related serum proteins. Methods Using proximity extension assay, we m
The cooperative emission of interacting nanocrystals is an exciting topic fueled by recent reports of superfluorescence and superradiance in assemblies of perovskite nanocubes. Several studies estimated that coherent coupling is localized to a small fraction of nanocrystals (10−7-10−3) within the assembly, raising questions about the origins of localization and ways to overcome it. In this work, w
In nanoscale systems coupled to finite-size reservoirs, the reservoir temperature may fluctuate due to heat exchange between the system and the reservoirs. To date, a stochastic thermodynamic analysis of heat, work, and entropy production in such systems is, however, missing. Here we fill this gap by analyzing a single-level quantum dot tunnel coupled to a finite-size electronic reservoir. The sys
In this mini-review, we briefly summarize some of the main concepts and ideas behind highly dilute self-bound quantum droplets of both binary and dipolar character. The latter type of systems has more recently led to the experimental discovery of a dipolar supersolid state that allows entirely new insights on this long-sought purely quantum state of matter, with exciting prospects for fundamental
We study quantum steering experiments without assuming that the trusted party can perfectly control their measurement device. Instead, we introduce a scenario in which these measurements are subject to small imprecision. We show that small measurement imprecision can have a large detrimental influence in terms of false positives for steering inequalities, and that this effect can become even more
Carbon materials with unique sp2-hybridization are extensively researched for catalytic applications due to their excellent conductivity and tunable physicochemical properties. However, the development of economic approaches to tailoring carbon materials into desired morphologies remains a challenge. Herein, a convenient “bottom-up” strategy by pyrolysis of graphitic carbon nitride (g-C3N4) (or ot
We theoretically investigate a supersolid structure taking the form of stacked, disk-shaped superfluid droplets connected via a dilute superfluid, in an antidipolar condensate. A phase diagram is determined for varying the particle number and scattering length, identifying the regions of a regular dipolar superfluid, supersolid stacks, and isolated stacked disk-shaped droplets in an experimentally
We present an approach to estimate the operational distinguishability between an entangled state and any separable state directly from measuring an entanglement witness. We show that this estimation also implies bounds on a variety of other well-known entanglement quantifiers. This approach for entanglement estimation is then extended to both the measurement-device-independent scenario and the ful
Technological and scientific advancements over the past 30-40 years make it possible to fabricate nanometer-sized systems where fluctuations and quantum effects are important features. These systems can be controlled and measured with high accuracy, making them suitable for exploring fundamental aspects of the microscopic world. This thesis makes contributions in this direction, focusing on the th
