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Abstract not available

Efter HSVs utvärdering av CI- utbildningarna fick högskolorna ett tydligt uppdrag att vid uppföljningen redovisa hur hållbar utveckling kommer in i utbildningarna. I planeringsförutsättningarna för de 5-åriga civilingenjörsutbildningarna vid LTH finns kravet på examination av minst 6 hp inom området.

Combustion modeling based on a multi-step global reaction mechanism [1] is applied to CFD (Computational Fluid Dynamics) analysis of a scaled swirl-stabilized 4th generation premixed DLE (Dry Low Emission) burner for gas turbines. The flexi-fuel burner consists of a MAIN premixed flame, a premixed PILOT flame and a confined RPL (Rich Pilot Lean) flame. Both steady-state RANS (Reynolds Averaged Nav

The Wilms' tumour gene 1 (WT1) protein is highly expressed in most leukaemias. Co-expression of WT1 and the fusion protein AML1-ETO in mice rapidly induces acute myeloid leukaemia (AML). Mechanisms behind expression of WT1, as well as consequences thereof, are still unclear. Here, we report that the fusion protein BCR/ABL1 increases expression of WT1 mRNA and protein via the phosphatidylinositol-3

Ischemic stroke affecting the adult brain causes increased progenitor proliferation in the subventricular zone (SVZ) and generation of neuroblasts, which migrate into the damaged striatum and differentiate to mature neurons. Meteorin (METRN), a newly discovered neurotrophic factor, is highly expressed in neural progenitor cells and immature neurons during development, suggesting that it may be inv

Abstract not available

Abstract not available

FK506 binding protein 65 (FKBP65) belongs to a group of proteins termed immunophilins that have a high binding affinity to immunosuppressant drugs as FK506 (tacrolimus) and rapamycin (sirolimus). Treatment of female premenopausal women with tacrolimus, which binds to FKBP65, has been reported to be followed by a strongly increased risk of ovarian cysts. We performed the present study to reveal how

Adult type 2 diabetes patients with GAD65 autoantibodies (GADA) are known as latent autoimmune diabetes in adults (LADA). It has been suggested that GADA in LADA patients preferentially bind to the N-terminal end of GAD65. Using the N-terminal end extension of (35)S-GAD65 generated by the pEx9 plasmid, we tested the hypothesis that GADA in LADA patients preferentially react with (35)S-GAD65 from t

OBJECTIVES: Essential hypertension is a complex condition whose cause involves the interaction of multiple genetic and environmental factors such as salt intake. Salt-inducible kinase 1 (SIK1) is a sucrose-nonfermenting-like kinase isoform that belongs to the AMPK (5' adenosine monophosphate-activated protein kinase) family. SIK1 activity is increased by high salt intake and plays an essential rol

När en väljare röstar med andras beteende i åtanke och politikutfall i sikte är det en "strategisk" röst. Den här studien relaterar väljares strategiska överväganden till olika steg i regeringsbildningsprocessen: att ta plats i parlamentet, ingå i regering, och påverka politikutfallet. Detta innebär att väljaren ibland tänker som ett parti på vad rösten kan få för konsekvenser. Utifrån detta perspIf a voter defects from preference under the consideration of policy outcomes and others' behavior, it is a "strategic vote". This thesis relates voters' strategic considerations to the government formation process: the chances for a party to gain seats, enter office, and affect overall policies. This implies that voters sometimes think like parties on the governmental consequences of the vote. Fr

Waiting times in cancer care is a patient safety risk that needs increased attention. Mechanisms and effects need to be clarified, waiting time statistics should be openly presented and evidence--based strategies should be implemented. Cancer patient pathways are implemented in Sweden during 2015-2018 and are expected to reduce waiting times for some patient groups, but cannot be expected to prese

It is generally believed that pregnancy is mediated by a Th2 response, which includes cytokines that promote placental growth and are involved in inducing tolerance to the foetus. If the balance between Th1/and Th2-mediated cytokines is disrupted, systemic and local changes could predispose the foetus to future disease. Therefore, a shift in the Th1/Th2 balance during pregnancy, possibly caused by

The proto-oncogene SKI is highly expressed in human myeloid leukemia and also in murine hematopoietic stem cells. However, its operative relevance in these cells remains elusive. We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compar

BACKGROUND: Obesity is a major risk factor for dyslipidemia, but this relationship is highly variable. Recently published data from 2 Danish cohorts suggest that genetic factors may underlie some of this variability.METHODS AND RESULTS: We tested whether established triglyceride-associated loci modify the relationship of body mass index (BMI) and triglyceride concentrations in 2 Swedish cohorts (t