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Treatment with melphalan-prednisone-thalidomide improves the outcome of patients with multiple myeloma and is now considered a standard of care for patients not eligible for transplantation. However, this treatment is a major source of morbidity. A meta-analysis of data from individual patients (n=1680) in six randomized trials was performed, comparing the effects of melphalan-prednisone-thalidomi

Background: Musculoskeletal disorders (MSDs) are a major reason for impaired work productivity and sick leave. In 2009, a national rehabilitation program was introduced in Sweden to promote work ability, and patients with MSDs were offered multimodal rehabilitation. The aim of this study was to analyse the effect of this program on health related quality of life, function, sick leave and work abil

IMPORTANCE: For individuals without a family history of colorectal cancer (CRC), colonoscopy screening every 10 years is recommended to reduce CRC incidence and mortality. However, debate exists about whether and for how long this 10-year interval could be safely expanded.OBJECTIVE: To assess how many years after a first colonoscopy with findings negative for CRC a second colonoscopy can be perfor

Deep Eutectic Solvents (DES) are a type of emerging solvent that are gaining in popularity for their versatile and adjustable properties, and components that can be safe, biodegradable and sustainably sourced. Here we investigate the interactions that give rise to their unique properties.The first paper looks at the question of how chirality in a component effects the DES structure. Many DES compo

INTRODUCTION: General Movement assessment (GMA) is considered the golden standard for early identification of infants with a high risk of developing cerebral palsy (CP). The aim of this study was to explore parents' lived experience of early risk assessment for CP using a mobile application for home video recording after discharge from hospital stay in the newborn period.METHODS: An inductive qual

Using scanning tunneling microscopy and spectroscopy we study the atomic scale geometry and electronic structure of GaAs nanowires exhibiting controlled axial stacking of wurtzite (Wz) and zinc blende (Zb) crystal segments. We find that the nonpolar low-index surfaces {110}, {101̅0}, and {112̅0} are unreconstructed, unpinned, and without states in the band gap region. Direct comparison between Wz

During graded exercise, systolic blood pressure (SBP) is expected to increase linearly, but other responses are observed. To date, a framework for algorithmic assessment of the shape of the SBP response is lacking, making its physiological and clinical relevance poorly understood. We aimed to algorithmically identify distinct SBP response shapes and analyze their association with clinical factors

Background: Standardised language tests provide a reliable framework for assessing language deficits in individuals with aphasia, but have long been lacking for various languages, including Swedish. The purpose of this study was to examine the diagnostic accuracy and establish the norm-references of the Swedish version of the Comprehensive Aphasia Test (CAT-S). Methods: Consecutive patients with a

Introduction: Familial risk of lung cancer (LC) is at the level of many common cancers (ca 2.0) but as cigarette smoking is the main cause of LC, it has remained undefined to what extent smoking contributes to the familial risk. We take advantage of the natural experiment of divorce. In Sweden, it has been customary that children stay with their mother after divorce. We thus hypothesize that only

Background: Familial clustering of initial primary lung cancer (IPLC) may be related to shared smoking habits, other environmental exposures and hereditary factors, but whether familial risk also influences the risk of second primary LC (SPLC) is not well known. We aimed to carry out a family study between first-degree relatives on SPLCs in Sweden. Methods: Population data on Swedish family relati

Background: Several case reports have recounted hiccups as a possible symptom of cancer, but potential associations in large study samples have not been examined. Methods: This population-based cohort study examined associations between hiccups and subsequent cancer diagnoses. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated. Results: Of 8466 patients diagnos

The attribution of joint and several liability to parent companies is a highly disputed area of the European Union competition law. The body of relevant case law distinguishes the following issues. The current practice of the attribution of parental liability is founded on three pillars. First, the presumption of decisive influence over a wholly-owned subsidiary, second, the concept of one underta

This study aimed to investigate the relationship between endorsement of aesthetic ideals and sexual satisfaction. Another aim was to examine the relationship between self-compassion and sexual satisfaction, as well as whether self-compassion affects the relationship between aesthetic ideals and sexual satisfaction. In addition, the study explored potential gender differences in these variables. Th

Background: Although up to 25% of proximal humeral fractures are isolated greater tuberosity fractures (IGTFs), comprehensive epidemiological data are lacking. Objectives: Describe the epidemiology and time trends of IGTF in Malmö, Sweden, 1944–2020. Methods: We identified IGTF in Malmö residents (≥18 years) by reviewing relevant radiology examinations during 17 sample years from 1944 to 2020. Fra

Research question: How do employees at call centres perceive algorithmic management? Purpose: This study aims to provide insights into how employees in a call centre perceive algorithmic management. Methodology: The study employed a qualitative research method, incorporating interviews with a relativist and social constructionist perspective, to fulfill its purpose and address the research questio

Purpose: Consistent, accurate postoperative guidance is crucial for early recovery and patient satisfaction in urology, especially for radical prostatectomy (RP) patients. However, patients often receive inconsistent information, highlighting the need for standardized, evidence-based postoperative care guidelines. Materials and Methods: We conducted a comprehensive review and evaluation of current

BACKGROUND: Some per- and polyfluoroalkyl substances (PFAS) such as perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) are very long-lived in humans, with serum half-lives of several years. In PFAS hot spots, such as Ronneby, Sweden, high exposures over time have led to markedly elevated serum PFAS levels, which may result in health risks