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The activity of the manganese (Mn) efflux transporter SLC30A10 in the liver and intestines is critical for Mn excretion and preventing Mn toxicity. Homozygous loss-of-function mutations in SLC30A10 are a well-established cause of hereditary Mn toxicity. But, the relationship between more common SLC30A10 polymorphisms, Mn homeostasis, and disease is only recently emerging. In 2021, the first coding

BACKGROUND: The ability of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to decrease certain microvascular events has called for the investigation of GLP-1 RAs against diabetic retinopathy (DR), but the evidence is limited. By combining data from observational and Mendelian randomization (MR) studies, we aimed to investigate whether GLP-1 RAs decrease the risk of DR.METHODS: We combined da

The frst May Measurement Month (MMM) campaign, a global blood pressure (BP) screening programme, began in 2017 as an initiative of the International Society of Hypertension.1 Two subsequent annual campaigns have also been completed in consecutive years2,3 and having had to defer activities due to the COVID-19 pandemic in 2020 the fourth campaign was run in 2021, the results of which are currently

Cardiovascular disease (CVD) remains one of the leading causes for increased morbidity and mortality in chronic kidney disease (CKD). Kidney transplantation is the preferred treatment option for CKD G5. Improved perioperative and postoperative care, personalized immunosuppressive regimes, and refined matching procedures of kidney transplants improves cardiovascular health in the early posttranspla

Contaminated drinking water (DW) is a major source of exposure to per- and polyfluoroalkyl substances (PFAS) at locations around PFAS production/use facilities and military airports. This study aimed to investigate quantitative relationships between concentrations in DW and serum of nine perfluoroalkyl acids (PFAAs) in Swedish adult populations living near contamination hotspots. Short-chained (PF

Deterministic Lateral Displacement (DLD) is a method capable of sorting cells based on size where mechanicalinteractions between a sufficiently large particle and obstacles in a microfludic pillar array force the particle tofollow a different trajectory than their smaller counterparts, resulting in continuous lateral separation. To extendthe capability of DLD, electrical interaction between partic

To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of seven genome-wide association studies totalling 5,325 HL cases and 22,423 controls. We identify five new HL risk loci at 6p21.31 (rs649775, P = 2.11 × 10-10), 6q23.3 (rs1002658, P = 2.97 × 10-8), 11q23.1 (rs7111520, P = 1.44 × 10-11), 16p11.2 (rs6565176, P = 4.00 × 10-8) and 20q13.12

Quantum cascade lasers (QCLs) are generally designed to avoid negative differential conductivity (NDC) in the vicinity of the operation point in order to prevent instabilities. We demonstrate that the threshold condition is possible under an inhomogeneous distribution of the electric field (domains) and leads to lasing at an operation point with a voltage bias normally attributed to the NDC region

Red kidney beans (Phaseolus vulgaris) processed to differ in distribution and content of indigestible carbohydrates were used to study hindgut fermentability and production of short-chain fatty acids (SCFA). Bean flours with low or high content of resistant starch (RS), mainly raw and physically-inaccessible starch, were obtained by milling the beans before or after boiling. Flours containing retr

The fermentability and pattern of short-chain fatty acids (SCFA) formed in the hindgut of rats given various combinations of dietary fibers (DF) and resistant starch (RS) were investigated. Highly fermentable indigestible carbohydrates, i.e., guar gum (GG), pectin (Pec) and high amylose cornstarch (HAS), and a DF with a relatively high resistance to fermentation, i.e., wheat bran (WB), were includ

The molecular weight distribution, measured by HPSEC, and the viscosity of the water-soluble dietary fiber isolated from variously processed/cooked carrots were investigated. The carrots were studied raw, frozen, blanched, soured, microwaved, and boiled. The fibers were isolated after enzymatic digestion of protein and starch to simulate the situation in the gastrointestinal tract. The degree of p

The formation of in vitro resistant starch (RS) during autoclaving and freeze-drying of wheat starch suspension was evaluated. A substantial amount of starch, up to 8% (dry weight basis), was rendered resistant to amylases during heat-treatment unless solubilised in KOH, whereas freeze-drying had only marginal effects. Heat-treated wheat starch was incorporated into test diets to provide different

The effect of phytic acid and polyphenols on the rate and extent of starch digestion as well as on fiber degradation was studied in vitro. Addition of phytic acid only had negligible influence on the enzyme activity of the amylases tested. In contrast, enzymes concerned with starch hydrolysis in the digestive channel (α‐amylase, amyloglucosidase/maltase) were inhibited by tannic acid, and to some

Noise is a common exposure in the occupational work environment. Earlier studies of occupational noise and pregnancy outcome are few and show mixed results. To investigate if objectively assessed exposure to occupational noise during pregnancy is associated with reduced intrauterine growth and/or preterm birth a nationwide cohort study of 857,010 single births was initiated. Individual information

Partially premixed combustion with low octane fuel aims to reduce NOx and soot emission simultaneously without fuel consumption penalty. Cylinder pressure based combustion phase control is an essential technology for partially premixed combustion. A novel closed-loop combustion phase control strategy for multiple combustion modes is proposed in the current study. The combustion modes are classifie

Molten-salt-based nanofluids and ionic-liquid-based nanofluids are developed for thermal storage and heat transfer at relatively high temperatures, in the past few years. Preparation and stabilization techniques are briefly introduced firstly, and then, thermal properties, e.g., specific heat, thermal conductivity and viscosity, are summarized and discussed in detail. The properties are not only a

Short chain fatty acids (SCFAs; acetic, propionic and butyric acid) are formed during bacterial fermentation of carbohydrates in the colon. The interest in SCFA production is related to an increasing body of knowledge of the physiological effects of these acids. SCFAs are important anions in the colonic lumen and serve locally as nutrients for the mucosa cells, stimulating mucosal proliferation an

Semiconductor nanowires have properties that make them potentially useful for applications in future electronic, photovoltaic, and optoelectronic devices. A powerful nanowire fabrication technique is the use of a nanoparticle as a preferential nucleation site, from which a nanowire grows. There has been significant progress in nanowire growth assisted by Au nanoparticles over the past 20 years. Ho