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We present a deterministic-lateral-displacement (DLD) device that extends the capabilities of this traditionally sizebased particle separation technique to also be sensitive to density. By the use of T-shaped posts instead of the normally cylindrical posts the particle trajectory through the device will be a function of its vertical position which in turn is determined by the buoyancy of the parti
To better understand how deformable and non-spherical particles behave in sorting devices based on deterministic lateral displacement we generate models of biological particles with tunable size, shape and mechanical properties using stop-flow lithography and we explore how these parameters play a role in our separation devices. Hollow and solid cylinders are compared with respect to their deforma
Deterministic Lateral Displacement (DLD) devices have been used to separate particles based on size [1] and shape [2]. Here we show how DLD devices can also be used to separate particles based on their ability to deform under shear forces. Varying experimental conditions allows us to vary the relative contributions of size, morphology and deformability. The ability to distinguish between cells bas
We have fabricated a device in which hollow nanowires (HNWs) lying on a glass surface are connected to microfluidic channels for the purpose of guiding DNA and to characterize the fluidic properties of our HNWs. The dimensions of our HNWs (inner diameter 10-80 nm, outer diameter 50-200 nm and length several μm) can be made on a scale much smaller than the size of a cell and on the same order of ma
Morphology represents a hitherto unexploited source of specificity in microfluidic particle separation and may serve as the basis for label-free particle fractionation. There is a wealth of morphological changes in blood cells due to a wide range of clinical conditions, diseases, medication and other factors. Also, blood-borne parasites differ in morphology from blood cells. We present the use of
Background: Borderline ovarian tumors (BOTs) are a subgroup of ovarian malignancies with low malignant potential. Very limited earlier data are available on familial clustering of BOTs with other cancers. We aim to explore histology-specific familial associations among BOTs and associations between BOTs and any invasive cancers.Methods: On the basis of 16.1 million individuals in the Swedish Famil
Kursguide - Course Syllabus • Fastställande Kursplanen är fastställd av Naturvetenskapliga fakultetens utbildningsnämnd 2016- 09-17 och senast reviderad 2016-09-17. Den reviderade kursplanen gäller från och med 2016-09-17, vårterminen 2017. Allmänna uppgifter Kursen är en valbar kurs på avancerad nivå för en naturvetenskaplig masterexamen i geologi. Undervisningsspråk: Engelska Kursens mål Kursens
https://www.geologi.lu.se/sites/geologi.lu.se/files/geom09_kursplan_2016-10-04.pdf - 2026-07-02
Microsoft Word - 20080915 N-fak Examensarbete avancerad nivå - Regler och rekommendationer.doc BESLUT Dnr N 2008/549 1 Naturvetenskap l iga fakul teten Utb i ldn ingsnämnden Regler och rekommendationer för examensarbeten på avancerad nivå vid naturvetenskapliga fakulteten fr.o.m. 2008-09-15. I detta dokument ges fakultetens regler och rekommendationer för examensarbeten på avancerad nivå, enligt b
Popular Abstract in English The ultimate goal of computer vision is to make computers "see" like humans do. Toward this goal, one essential step is to enable computers to perceive a three-dimensional (3D) space as in the real world. In this thesis, we investigate the problem of reconstructing a 3D scene model from ordinary two-dimensional (2D) images. More specifically, given a set of images of thThis thesis is focused on geometric computer vision problems. The first part of the thesis aims at solving one fundamental problem, namely low-rank matrix factorization. We provide several novel insights into the problem. In brief, we characterize, generate, parametrize and solve the minimal problems associated with low-rank matrix factorization. Beyond that, we give several new algorithms based o
This thesis consider the improvement of the simulation tools used to describe high energy particle collisions. These simulation programs are normally referred to as event generators. The emphasis is on two specific parts of the event generation: the introduction of radiation of weak bosons associated with the collision and a new model for colour reconnection. Each collision contains significant
Using Deterministic Lateral Displacement (DLD), we are able to separate bacteria by their size and their chain length. This separation enables the study of these properties as factors of virulence.
A combination of mesoscale hydrodynamic simulations and microfluidic experiments are used to explore the use of cells' mechanical and dynamical properties as biomarkers for separation. Dynamic behaviour of red blood cells (RBCs) within deterministic lateral displacement (DLD) devices is investigated within various array geometries and for different viscosity contrasts between the intra- and extra-
Mesoscopic simulations with two-dimensional (2D) models have been performed to elucidate the dynamics of deformable red blood cells (RBCs) in deterministic lateral displacement (DLD) devices. Several shapes of posts, including circular, diamond, square and triangular structures and RBCs with different rigidities are considered. In comparison to rigid particles, the deformable RBCs exhibit much mor
Optical mapping relies on the preparation of fluorescent DNA. DNA must be imaged with good signal to noise and therefore the background of unwanted DNA fragments, fluorescent dyes and other reagents need to be removed. We use deterministic lateral displacement to separate 48.5 kbp DNA from < 10 kbp DNA. We also show the removal of 48.5 kbp DNA fragments from a background of fluorescent ATTO647N mo
A cluster of metabolic factors have been merged into an entity named the metabolic syndrome. Although the characteristics of this syndrome have varied over time the presently used definition was established in 2009. The presence of three abnormal findings out of five components qualifies a person for the metabolic syndrome: elevated waist circumference, elevated triglycerides, reduced high-density
