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Immune checkpoint inhibitor therapies targeting PD‐1/PD‐L1 are now the standard of care in oncology across several hematologic and solid tumor types, including triple negative breast cancer (TNBC). Patients with metastatic or locally advanced TNBC with PD‐L1 expression on immune cells occupying ≥1% of tumor area demonstrated survival benefit with the addition of atezolizumab to nab‐paclitaxel. How
Aims Delcasertib is a selective inhibitor of delta-protein kinase C (delta-PKC), which reduced infarct size during ischaemia/reperfusion in animal models and diminished myocardial necrosis and improved reperfusion in a pilot study during primary percutaneous coronary intervention (PCI) for ST elevation myocardial infarction (STEMI). Methods and results A multicentre, double-blind trial was perform
Based on a combined three locus analysis two new genera, Charcotiana and Amundsenia, are proposed in the lichen family Teloschistaceae, subfamily Xanthorioideae. Charcotiana includes the new species C. antarctica, which is known only from continental Antarctica. The bipolar genus Amundsenia includes the new species A. austrocontinentalis, which is also known only from continental Antarctica, and t
Collection and recycling systems for small waste electrical and electronic equipment (WEEE) in Europe has been developed based on the 2003 EU Directive on Waste Electrical and Electronic Equipment (WEEE Directive), which was transposed into the national laws of EU Member States. With the growing recognition on the potential for small WEEE to supply mateirals that are critical to the continued grow
The concept of the FE is relevant in the EU VAT from the two main perspectives as regards the cross-border supplies of services: entitlement of the MS to tax the supply and distribution of VAT accounting obligations between the supplier and the customer. This influences VAT burden and cash flows of both the parties to the supply and the state in which the supply is subject to VAT. The concept is,
Brottsoffret har sedan det introducerades som ett begrepp på 1970-talet allt mer kommit att dominera den politiska och akademiska debatten kring brott och straff. Mitt syfte med den här uppsatsen är att ur ett kritiskt perspektiv granska den svenska straffrätten ur ett brottsofferperspektiv. Vem är brottsoffret? Det finns ingen övergripande definition av vem brottsoffret är. En fråga som därför uThe term “crime victim” was introduced in the Swedish language in the 1970s. Since then it has more and more started to dominate the political and academic debate about crime and punishment. My aim with this essay is to from a critical point of view, review the Swedish criminal law from a crime victim-perspective. Who is the crime victim? There is no overall definition of who can qualify as a cri
Föräldraskap, intervention och prevention vid barnövervikt/fetma hos förskolebarn med utgångspunkt ifrån ett barn- och familjepsykologiskt perspektiv är ämnet för denna uppsats. Psykologiska faktorer av betydelse för barns ätande, matens betydelse i familjen, föräldrastress kopplad till barns ätande, liksom tidpunkt och inriktning ifråga om intervention och prevention är ämnen som belyses och diskParenting, intervention and prevention of pediatric overweight/obesity in preschool children from a psychological, child-and family oriented perspective is the subject in this paper. Psychological factors of importance for children's eating, the importance of food in the family, parental stress related to children's eating, timing and focus in intervention and prevention are subjects, high
The initial part of this paper presents an overview of research conducted on switching costs and their implications. Different types of switching costs are identified and categorised according to available research and examples are given. Further, switching costs are with the help of previous research put in relation to various business actions we may encounter on an everyday basis and how they af
Carbon emissions have recently been put under the spotlight since it is widely accepted that global warming is caused by the emission of greenhouse gases, of which carbon dioxide is the main component. One of the fastest rising sources of emissions from carbon emissions is the transport sector, with emissions often rising faster than the GDP growth rates of developing countries. The estimated shar
Pinus sylvestris (tall) är en betydelsefull trädart i Sverige och Europa, både ekonomiskt och kulturellt sett. Trädet infekteras dock av den destruktiva rottickan (Heterobasidion spp.) vilket resulterar i stora ekonomiska förluster inom skogsindustrin, med en uppskattad monetär förlust på ca 800 miljoner EUR årligen i Europa. Det är svårt att upptäcka svampen i tidiga infektionsstadier eftersom inPinus sylvestris (Scots pine) is an important tree species in Sweden and Europe, both economically and culturally. However, the highly destructive root rot fungi Heterobasidion spp. infect P. sylvestris and cause major economic losses in the forest industry, estimated to about 800 million EUR annually in Europe alone. Detection of the fungus in early stages is hard, as the infection mainly stays i
The purpose of this study is to examine how the capital structure in swedish listed firms changed during the Corona-crisis. The study focuses on the years 2017-2022 to compare before and during the crisis. The study also uses six control variables to capture changes in capital structure. To compare capital structure, the study uses three types of debt ratios, total, short and long term leverage. T
This thesis examines the complex relationship between networking and resource mobilisation in the context of entrepreneurship. The study investigates the extent to which different types of ties, namely strong, weak and new ties, contribute to an entrepreneur's ability to acquire resources. This qualitative study employed semi-structured interviews with eight founders in Sweden and the Netherla
Despite Sweden having implemented strict laws against child abuse and adopting the Convention on the Rights of the Child into law, child abuse remains a significant societal issue. Although it is clear that legal changes play a role in strengthening the protection and rights of children, legislation and actual circumstances do not always align. This study aimed to highlight different experiences o
On the 23 September 2020 the European Commission launched the Pact on Migration and Asylum, introducing five legislative proposals, which inter alia aim at ensuring that only people with clear protection needs enter the European Union (EU). To reach this objective, the European Commission introduced a so-called pre-entry phase, consisting of firstly, the proposed screening procedure, a five-day pr
Efter aktiveringen av Internationella brottmålsdomstolens jurisdiktion över aggressionsbrottet i juli 2018 är dessa gärningar för första gången sedan Nürnbergtribunalen möjliga att väcka åtal för i en internationell domstol. Aggressionsbrottet kan bara begås av personer i position att effektivt utöva kontroll över eller styra politiska eller militära handlingar av en stat. Detta inkluderar, men inFollowing the activation of the International Criminal Court’s jurisdiction over the crime of aggression in July 2018, these acts are for the first time since the Nuremberg Tribunal possible to prosecute before an international court. The crime of aggression may only be conducted by persons in a position effectively to exercise control over or direct the political or military action of a State. Th
