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Smad5 is known to transduce intracellular signals from bone morphogenetic proteins (BMPs), which belong to the transforming growth factor-beta (TGF-beta) superfamily and are involved in the regulation of hematopoiesis. Recent findings suggest that BMP4 stimulates proliferation of human primitive hematopoietic progenitors in vitro, while early progenitors from mice deficient in Smad5 display increa
Label-free LC-MS methods are attractive for high-throughput quantitative proteomics, as the sample processing is straightforward and can be scaled to a large number of samples. Label-free methods therefore facilitate biomarker discovery in studies involving dozens of clinical samples. However, despite the increased popularity of label-free workflows, there is a hesitance in the research community
Calcitonin gene-related peptide (CGRP) research was initiated by Poyner et al.,(1) who found that the calcitonin gene encodes the 37-amino acid neuropeptide CGRP in neuronal tissue. Within months, the Lund group produced antibodies toward α-CGRP and developed sensitive methods to study the role of this peptide in the cranial circulation. Intracranial vessels and the trigeminal ganglion harbor this
Sustainable development requires coordination among multi-level actors to achieve set targets, with networks playing a key role in sharing knowledge and fostering collective actions. These networks’ success hinges on member engagement, but since participation is voluntary, members choose their level of involvement. Despite the importance, factors influencing network engagement remain rather scarce
Granule neurons of the dentate gyrus (DG) of the hippocampus undergo continuous renewal throughout life. Among cell cycle regulators, cyclin-dependent kinase 2 (Cdk2) is considered as a major regulator of S-phase entry. We used Cdk2-deficient mice to decipher the requirement of Cdk2 for the generation of new neurons in the adult hippocampus. The quantification of cell cycle markers first revealed
Revised simulation theory (Goldman, 2006) allows mental state attributions containing some or all of the attributor’s genuine, non-simulated mental states. It is thought that this gives the revised theory an empirical advantage, because unlike theory theory and rationality theory, it can explain egocentric bias (the tendency to over attribute ones’ own mental states to others). I challenge this vi
Forskarna inom detta område arbetar med forskning om bruk, skadligt bruk och beroende av alkohol och andra droger, ofta ur ett socialvetenskapligt perspektiv. Även beroendeproblem kopplade till spel om pengar och dopning berörs. Forskningen rör såväl människors livsvillkor och erfarenheter som vårdens, socialtjänstens och andra samhällsaktörers arbete. Forskningen har en bred metodologisk ansats oResearchers in this area study the use, harmful use, and dependence on alcohol and other drugs, often from a social science perspective. Gambling-related addiction problems and doping are also included. The research addresses both people’s living conditions and experiences, and the work of healthcare services, social services, and other societal actors. It takes a broad methodological approach and
Due to social and environmental crises, the concept of sustainability has grown in importance in our society over the past years. Things are changing, even in the financial industry. From the perspective of investors, the general public, and enterprises, Corporate Social Responsibility and the creation of sustainable value are becoming more and more significant. One of the most cutting-edge tools
The aggregating proteoglycans (aggrecan, versican, neurocan, and brevican) are important components of many extracellular matrices. Their N-terminal globular domain binds to hyaluronan, but the function of their C-terminal region containing a C-type lectin domain is less clear. We now report that a 90-kDa protein copurifies with recombinant lectin domains from aggrecan and versican, but not from t
The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disruption of E2-2 and HEB results in failure to express the early lymphoid program in Co
Local commercial fishing is often claimed to attract tourists to coastal communities. We investigate the impact of local fishing on tourism demand, measured as overnight stays, in Sweden. Using municipal-level data for the period 1998–2015, we perform a quantitative analysis using ordinary least squares (OLS) as well as panel-data methods that take unobserved heterogeneity between municipalities i
Internationella Miljöinstitutet (IIIEE) är ett internationellt och tvärvetenskapligt centrum som bedriver forskning och utbildning vid Lunds universitet. Vi bidrar till hållbarhetslösningar åt myndigheter och näringsliv genom forskning inom styrningsprocesser, policyutvärdering och affärsmodeller såväl som utveckling av visioner och scenarier för en hållbar framtid.The International Institute for Industrial Environmental Economics (IIIEE) is an international and interdisciplinary centre for research and education at Lund University. We promote sustainable solutions pursued by public authorities and businesses by assessing governance and management processes, evaluating policy interventions and business models, and exploring visions and scenarios for sustaina
The Nordic countries have often been seen as “fore-runners” of energy efficiency in buildings in terms of both 1) the implementation of policy instruments and 2) the evaluation of actual effects. Since the 1970s, the Nordic countries have introduced a range of policy instruments for energy conservation in buildings. Interestingly, there are contrasting policy “styles” and experiences across the No
