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Objective: Knee osteoarthritis (OA) is associated with meniscal degeneration that may involve disorganization of the meniscal collagen fiber network. Our aims were to quantitatively analyze the microstructural organization of human meniscus samples in 3D using micro-computed tomography (μCT), and to compare the local microstructural organization between OA and donor samples. Method: We collected p

Background: PAM50 breast cancer intrinsic subtyping adds prognostic information in early breast cancer; however, the role in metastatic disease is unclear. We aimed to identify PAM50 subtypes in primary tumors (PTs) and metastases to outline subtype changes and their prognostic role. Methods: RNA was isolated from PTs, lymph node metastases (LNMs), and distant metastases (DMs) in metastatic breast

Treatment with IgG against the malondialdehyde (MDA)-modified apolipoprotein B-100 epitope p45 reduces atherosclerosis in experimental models. This study investigated the association between p45 IgG autoantibodies and plaque inflammation in subjects with advanced cardiovascular disease.

BACKGROUND: The use of percutaneous coronary intervention (PCI) to treat unprotected left main coronary artery disease has expanded rapidly in the past decade. We aimed to describe nationwide trends in clinical practice and outcomes after PCI for left main coronary artery disease. METHODS AND RESULTS: Patients (n=4085) enrolled in the SCAAR (Swedish Coronary Angiography and Angioplasty Registry) a

Introduction: During airway infection, upregulation of proinflammatory cytokines and subsequent immune cell recruitment is essential to mitigate bacterial infection. Conversely, during prolonged and non-resolving airway inflammation, neutrophils contribute to tissue damage and remodeling. This occurs during diseases including cystic fibrosis (CF) and COPD where bacterial pathogens, not least Pseud

BACKGROUND: Metformin use has been associated with improved survival in patients with different types of cancer, but research regarding the effect of metformin on cutaneous melanoma (CM) survival is sparse and inconclusive.OBJECTIVES: To investigate the association between metformin use and survival among patients with CM and diabetes.METHODS: All adult patients with a primary invasive CM between

INTRODUCTION: Immune cells in the tumour microenvironment are associated with prognosis and response to therapy. We aimed to comprehensively characterise the spatial immune phenotypes in the mutational and clinicopathological background of non-small cell lung cancer (NSCLC).METHODS: We established a multiplexed fluorescence imaging pipeline to spatially quantify 13 immune cell subsets in 359 NSCLC

The NNBAR experiment for the European Spallation Source will search for free neutrons converting to antineutrons with an expected sensitivity improvement of three orders of magnitude compared to the last such search. This paper describes both the simulations of a key component for the experiment, the neutron optical reflector and the expected gains in sensitivity.

Background: Metastatic breast cancer (MBC) is a challenging disease, and despite new therapies, prognosis is still poor for a majority of patients. There is a clinical need for improved prognostication where immuno-oncology markers can provide important information. The aim of this study was to evaluate serum immuno-oncology markers in MBC patients and their respective relevance for prediction of

Background: Functionally disruptive variants in the glucokinase gene (GCK) cause a form of mild non-progressive hyperglycemia, which does not require pharmacological treatment. A substantial proportion of patients with type 2 diabetes (T2D) carry GCK variants. We aimed to investigate whether carriers of rare GCK variants diagnosed with T2D have a glycemic phenotype and treatment response consisten

BACKGROUND: GH therapy in adult patients with GH deficiency (GHD) was approved over 10 yr ago, and the indication has subsequently gained broad acceptance. The HypoCCS surveillance database is a suitable means to examine the evolution of diagnostic patterns since 1996.METHODS: Baseline demographics, reported cause of GHD, and diagnostic tests were available from 5893 GH-treated patients. Trends fo

Myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MRTFA, and MRTF-B/MRTFB) suppress production of pro-inflammatory cytokines and chemokines in human smooth muscle cells (SMCs) through sequestration of RelA in the NF-κB complex, but additional mechanisms are likely involved. The cGAS-STING pathway is activated by double-stranded DNA in the cytosolic compartment and acts throug

BACKGROUND: Perfluoroalkyl substances (PFAS) have been associated with impaired antibody levels after childhood vaccinations and immunosuppressive effects in animals. However, the in vivo effects of PFAS on antigen specific human T cell responses have not been investigated in adults. In Ronneby, Sweden, the drinking water of one of the water works was previously highly contaminated with primarily

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases with inflammation affecting small blood vessels and includes granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). In this study, we investigated granulocyte and monocyte subsets in a large cohort of AAV patients with emphasis on disease activity and tendency to relapse. A

Toxicological testing in mice was conducted on PM2.5 particles from stressed burning of two types of candles (white and blue) and on PM2.5 collected indoor and outdoor of fifteen occupied homes in southern Sweden. As an indicator of toxicity, the ability to generate Reactive Oxygen Species (ROS) was also assessed for all pooled samples: candle white, candle blue, indoor, and outdoor. Higher toxici

Affiliated Contact details Email: caterina [dot] doglioni [at] fysik [dot] lu [dot] seOrganisation Particle and nuclear physics Service point: 14 WebpageCaterina Doglionis profile in Lund University research portalOther affiliations Project manager Particle and nuclear physics Senior lecturer Particle and nuclear physics Member of Strategic Research Area eSSENCE: The e-Science Collaboration Public

https://www.particle-nuclear.lu.se/caterina-doglioni - 2026-07-24

DEPARTMENT OF HISTORY SASH64, Swedish History from a Nordic Perspective Literature list approved by the board 2024-05-25 Apps, Lara and Gow, Andrew (2003). Male witches in early modern Europe. Manchester: Manchester University Press. pp. 65-94 & 159-166. (36 p., *Finn: https://finn.lub.lu.se/EdsRecord/cat02271a,atoz.ebs313998e, doi: https://doi.org/10.7765/9781526137500 Berggren, Henrik and Trädgå

https://www.ht.lu.se/media/utbildning/dokument/kurser/SASH64/20262/Literature_list_SASH64_1.pdf - 2026-06-29

 LTH:s 13:e Pedagogiska Inspirationskonferens, 4 december 2025 Abstract— Collaborative learning is a pedagogical approach that emphasizes group work and project-based learning to promote problem-solving skills and deeper understanding. However, collaborative learning also presents challenges. One common issue is social loafing, whereby people contribute less to a group effort than they would if t

https://www.lth.se/fileadmin/cee/genombrottet/konferens2025/D3_Sonntag.pdf - 2026-06-09

LTHs 6:e Pedagogiska inspirationskonferens 2010 Knowledge Diversities and Group Dynamics within International Master Programs Florian Hug and Nafiseh Seyed Mazloum Abstract—Although international students are allowed to study at Swedish universities since 1985, the Swedish university land- scape has undergone a strategic internationalization mainly during the recent few years. With a steadily grow

https://www.lth.se/fileadmin/lth/genombrottet/konferens2010/51_Hug_Mazloum.pdf - 2026-06-09

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https://www.lth.se/english/cee/about-cee/staff/academic-staff/ - 2026-06-09