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Background--Interleukin-23 (IL-23) has been implicated in inflammatory and autoimmune diseases by skewing CD4+ T helper cells towards a pathogenic Th17 phenotype. In this study we investigated the presence of IL-23 receptor (IL-23R)-expressing cells in the atherosclerotic aorta and evaluated the effect of IL-23R deficiency on atherosclerosis development in mice. Methods and Results--We used hetero
The impact of the transition to modern economic growth on the distribution of income is widely debated. The experience of early industrializers like Britain and the US has informed much of the debate, lending support to the idea embedded in the models of Kuznets and Lewis that real wages of laborers tend to lag behind the growth of GDP per capita in the early stages of economic development. We exa
The influence of boiling and storage on dietary fibre and digestible carbohydrates was investigated in eight different carrot cultivars. The content of total dietary fibre was in the range 252-291 g kg-1 DW and was generally at the higher end for the early cultivars and at the lower end for the late ones. During storage, there was a decrease in the soluble fibre content in all cultivars and genera
Knowledge of infective endocarditis (IE) caused by Streptococcus dysgalactiae (SD) is limited. This study aimed to identify the clinical and microbiological features of SD-caused IE and to investigate any possible synergy between penicillin and gentamicin on SD isolates. Cases of IE 2008–2016 due to SD reported to the Swedish Registry of Infective Endocarditis (SRIE) were identified. Isolates were
The human host defense peptide LL-37 possesses antimicrobial activity but also affects host cell function and viability. Mast cells are involved in innate immunity but no data have been presented on effects of LL-37 on human mast cell viability and export of nucleic acids. Here, we demonstrated by immunofluorescence microscopy that synthesized LL-37 was internalized by human LAD2 mast cells and de
The interaction of two confined coaxial jets has been studied using Computational Fluid Dynamics. Annular jet flows over 8 flat blade swirl generator. Numerical simulation uses RNG k- ϵ turbulence model. These models are suitable for turbulent swirl dominated flows. Intermediate swirl injector has been simulated and the flow patterns for non-reactive and reactive cases are contrasted. Low swirling
Corrosion of steel reinforcement is a common cause of deterioration in reinforced concrete bridges and many existing bridges are damaged to varying degrees. The rate of deterioration of the bridge stock has been shown to increase due to climate change. Unsympathetically, the demand for load-carrying capacity is however often increased with time. Therefore there is an increasing need for reliable m
Vibration of machinery and construction work are major sources of noise and vibration pollution in the urban environment. The frequencies dominating the vibration, and the distances over which it spreads via the ground, depend on the source. However, soil stratification and foundation type have a significant influence. Thus, in order to achieve fair accuracy in the prediction of ground vibration c
The Monχey project will provide a large and homogeneous set of stellar yields for the low- and intermediate- mass stars and has applications particularly to galactic chemical evolution modelling. We describe our detailed grid of stellar evolutionary models and corresponding nucleosynthetic yields for stars of initial mass 0.8 M⊙ up to the limit for core collapse supernova (CC-SN) ≈ 10 M⊙. Our stud
The ability of chevrons at the top edge of a backward-facing step to reduce downstream surface pressure fluctuations is investigated numerically. Three different chevron configurations are compared against a baseline case without chevrons. Low frequency reduction in the surface pressure fluctuations is observed for two of the configurations. The chevrons do not appear to have a significant effect
In this paper, we introduce a novel framework for semi-parametric estimation of an unknown number of signals, each parametrized by a group of components. Via a reformulation of the covariance fitting criteria, we formulate a convex optimization problem over a grid of candidate representations, promoting solutions with only a few active groups. Utilizing the covariance fitting allows for a hyperpar
This paper presents an innovative study of the port system of Rome in Imperial times through the application of an integrated approach to both archaeological analysis and material evidence. Specifically, it seeks to provide a more complete contextualization and understanding of the port system of Rome by focusing on the exploration of the physical geography of the river Tiber and its transformatio
Event detection and classification algorithms are resilient towards aggressive resource-aware optimisations. In this paper, we leverage this characteristic in the context of smart health monitoring systems. In more detail, we study the attainable benefits resulting from tailoring Support Vector Machine (SVM) inference engines devoted to the detection of epileptic seizures from ECG-derived features
This paper discusses new improvements of a form-based algorithm, which is used to estimate flow distribution over a continuous surface. In the new form- based algorithm (IFBFD), cells in a DEM are classified into five different classes. The classes are Peaks, Complicated, Sinks, Flats and Undisturbed cells. The method of how to estimate the flow distribution from each cell depends on its class. Es
COVID-19 is characterized by a dysregulated and excessive inflammatory response and, in severe cases, acute respiratory distress syndrome. We have recently demonstrated a previously unknown high-affinity interaction between the SARS-CoV-2 spike (S) protein and bacterial lipopolysaccharide (LPS), leading to the boosting of inflammation. Here we present a mouse inflammation model employing the coadm
We recently described four distinct types of plexiform lesions in human idiopathic and familial pulmonary arterial hypertension (PAH) [1], visualising the three-dimensional lesion structure using synchrotron-based phase-contrast micro-CT (SPµCT). Two types, 1 and 2, are shunt-type lesions that connect pulmonary arteries to the bronchial circulation: type 1 to the vasa vasorum, and type 2 to peribr
The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and results of a successful placebo-controlled clinical trial are presented.
