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The rapidly growing collection of diverse genome-scale data from multiple tumor types sheds light on various aspects of the underlying tumor biology. With the objective to identify genes of importance for breast tumorigenesis in men and to enable comparisons with genes important for breast cancer development in women, we applied the computational framework COpy Number and EXpression In Cancer (CON
Three mononuclear metal complexes, [{PO2((NHPy)-Py-2)(2)}(2)M] [Py-2 - 2-pyridyl; M - Zn (1), Ni (2), Co (3)], have been synthesized by reacting metal nitrates with tetrakis(2-pyridylamino)phosphonium chloride, [P((NHPy)-Py-2)(4)]Cl, under solvothermal reaction conditions. The ligand, [P((NHPy)-Py-2)(4)]Cl, is hydrolyzed in the reaction medium. All of the complexes are isostructural and show an oc
Popular Abstract in Swedish Övergripande syfte Syftet med avhandlingen var att utvärdera hur en förenklad metod för diagnostisering av blodproppar i benets djupa ådror (djup ventrombos (DVT)) fungerar i svensk rutinsjukvård. Den förenklade metoden innebär användning av en strukturerad klinisk sannolikhetsbedömning tillsammans med ett blodprov (D-dimer test). Vi jämförde också vår D-dimermetod med The combination of pre-test clinical probability assessment and D-dimer test is now widely applied in the diagnostic process of DVT. The general objective of the present investigation was to validate these results in a Swedish routine emergency setting were the prevalence of the disease is high and were the clinical probability assessment was handled by many junior physicians. Furthermore, our aim
BACKGROUND: Animal studies indicate that some phthalate metabolites may harm female reproductive function. OBJECTIVES: We assessed the associations between exposure to phthalate metabolites and pregnancy loss. METHODS: Using a previously established cohort of couples planning their first pregnancy, we analyzed four primary and two oxidized secondary phthalate metabolites in urine samples collected
A functionally normal TP53 is essential to protect organisms from developing cancer. Somatic mutations in the gene represent one of the highest recurring perturbations in human tumours, including colorectal cancer (CRC). However, the variegated phenotype of wide spectrum of somatic mutations in TP53 and the complexity of the disease prevent a straight interpretation of the mutational analysis in t
Abstract is not available
Popular Abstract in Swedish Förbättrad bedömning av njurskador hos barn med urinvägsinfektioner Urinvägsinfektioner är vanliga och förekommer hos 1 - 4 % av alla barn. Urinvägsinfektion kan ge upphov till njurinflammation och ibland kvarstående njurskada (ärr) efter läkning. Det finns risk för fortskridande njurskada om det finns kvarstående njurskada efter en urinvägsinfektion, om barnet får uppThe aim of the present thesis was to define and evaluate a strategy for identification of children who are at risk of developing progressive renal lesions after acute pyelonephritis. Tc-DMSA renal scintigraphy is widely accepted as the most sensitive method for detecting parenchymal lesions and diagnosing acute pyelonephritis. Qualitative and quantitative evaluation standards were elaborated to i
Popular Abstract in Swedish I Big Bang, då vårt Universum skapades, bildades i princip endast de två lättaste grundämnena, väte och helium. Alla andra grundämnen har skapats, och skapas fortfarande, i olika typer av stjärnor under olika utvecklingsfaser. Detta betyder att precis alla atomer, förutom väte och helium, som bygger upp alla saker, växter, djur och människor i vår omgivning, har bildatsDisregarding the small primordial traces of the lightest elements, all metals have been formed in stellar processes, which means that the relative amount of metals in the Universe increases for every stellar generation. This build-up of elements is called chemical evolution and might be used both to constrain stellar models as well as understanding the formation and evolution of stellar population
The thermal insulation of clothing is commonly determined by dry thermal manikins either made of plastic or metal. For the determination of evaporative resistance of clothing ensemble, there exist three types of manikin methods: pre-wetted underwear or “skin” covered on dry manikins, the manikin with regulated constant water supply to the “skin” surface and the sweating fabric manikin based on a w
The main concern of this book is to determine when the gap in living standards between the East and the West emerged. Why did Europe experience industrialization and modern economic growth before China, India, or Japan? This is one of the most fundamental questions in Economic history and one that has provoked intense debate. The established view, dating back to Adam Smith, is that the gap emerged
Urban Squares suggests a specific and fresh take on agorology – the study of urban squares. The approach is one of recording everyday life and focusing on different ways to describe and investigate the public life and space of urban squares. The book comprises four empirical case studies of squares focusing especially on the urban material culture and spatio-temporal changes of these squares. The
Popular Abstract in Swedish Intresset för biobränsle som en alternativ energiresurs har ökat eftersom utsläppen av CO2, NOx och SO2 bör sänkas. Användningen av biobränsle i en trycksatt fluidiserad bädd förbrännare/förgasare är därför en teknik som är lovande. En fluidiserad bädd har en rad fördelar såsom effektiv värmeöverföring, bränsleflexibilitet och låg förbränningstemperatur. Trots sina fördIncreasing awareness of the need of reducing CO2, NOx and SOx emissions from combustion systems has led to a strong interest in biomass as a fuel source. Using it in combination with fluidised bed combustion technology can lead to a lowering of NOx emissions to the atmosphere. However, this is not a problem-free technique, since the flue gas can contain ammonia, NOx and tar. The fluidised bed can
This book explores the historical, biblical, christological, trinitarian, and ecclesiological dimensions of soteriology in Jewish-Christian relations.
The European Union has initiated a number of initiatives to improve resource efficiency in Europe. The Ecodesign Directive is one of the policy instruments that could aid the transition towards a more resource efficient economy. This paper examines the potential benefits and disadvantages in applying the Directive for this purpose, and reflects on the potential to apply certain types of standards.
This study investigates the impact of childhood health on labor market outcomes. We used type 1 diabetes as an instrument of health because its cause is multifactorial and it is triggered by a complex combination of genetic and environmental components; its incidence is low and unforeseeable for the individual; and its onset may be considered an exogenous health shock. Using data from the Swedish
