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Arabidopsis thaliana NUDT1 (AtNUDT1) belongs to the Nudix family of proteins, which have a diverse range of substrates, including oxidized nucleotides such as 8-oxo-dGTP. The hydrolysis of oxidized dNTPs is highly important as it prevents their incorporation into DNA, thus preventing mutations and DNA damage. AtNUDT1 is the sole Nudix enzyme from A. thaliana shown to have activity against 8-oxo-dG
Background Matrix metalloproteinases (MMP´s) are known biomarkers of atherosclerosis. MMP´s are also involved in the pathophysiological processes underlying chronic obstructive pulmonary disease (COPD). Cigarette smoking plays an important role in both disease states and is also known to affect the concentration and activity of MMP´s systemically. Unfortunately, the epidemiological data concerning
Endocrine disorders that lead to a state of chronic high blood glucose levels are collectively referred to as diabetes. This metabolic disease is mainly categorized into type 1 (T1D) and type 2 diabetes (T2D). These diabetic forms originate from distinct triggering environmental, genetic, and altered mechanisms. T2D is a consequence of metabolic load, peripheral insulin resistance, and failure of
This article explores middle managers in the professions from their position in the sandwiched middle. Based upon interviews with senior academics in management roles and their subordinates in UK business schools, we investigate this experienced middle through a metaphor that informs one particular subject position: to be an umbrella carrier. This position entails protecting subordinates from what
This article explores the process of the formalisation of the Swedish financial market, through an analysis of commercial bank lending in the late nineteenth and early twentieth century. The analysis shows that the incorporation of Swedish business around the turn of the century led to a shift from lending primarily backed by name security to an increased use of mortgage and shares as collateral -
We propose a modulus based zero-forcing (MZF) detector for multi-input multi-output (MIMO) channels. Traditionally, a ZF detector nulls out interference from other layers when detecting a certain layer. While this is conceptually simple, it can result in considerable noise-enhancement. In many communication systems, finite alphabets such as M quadrature-amplitude-modulation (QAM) are used, which c
In this paper, we consider capacity degradations stemming from potential hardware impairments (HWI) of newly proposed Large Intelligent Surface (LIS) systems. Without HWI, the utility of surface-area (the first-order derivative of the capacity with respect to surface-area) is shown to be proportional to the inverse of it. With HWI, the capacity as well as the utility of surface-area are both degra
Using infrared reflection spectroscopy the authors show that the phase transitions from disordered high temperature Β- Zn4 Sb3 into the increasingly higher ordered and complex structured low-temperature phases α and α′ are accompanied by a significant increase in the free charge carrier density and a concomitant increase of the effective scattering rate.
Single crystals of Nd0.6Gd0.4Se1.85 have been prepared by chemical transport reactions starting from pre-annealed powder samples. Satellite reflections observed in X-ray and electron diffraction experiments indicate the presence of a two-dimensional lattice distortion. The origin of this is a site occupancy wave and, coupled to this, a charge density wave in the planar selenium layer of this compo
Homogeneous Charge Compression Ignition (HCCI) holds promise for reduced emissions and increased efficiency compared to conventional internal combustion engines. As HCCI lacks direct actuation over the combustion phasing, much work has been devoted to designing controllers capable of set-point tracking and disturbance rejection. This paper presents results on model predictive control (MPC) of the
For various industries worldwide, recent years have been defined by the remarkable growth of e-commerce. Enabled by the Internet, retailers can reach more customers, spread much further in the distribution chain, and optimize their resources. In the new market environment, customer experience has become a source of competitive advantage. This study investigates the role of last mile delivery in th
This article contributes to the growing literature on the impact of colonial legacies on long-run development. We focus on Kenya, where it is previously argued that land tenure and taxation policies created an impoverished class of wage workers leading to lower living standards, high inequality, and stunted economic development. We take issue with this interpretation. Using archival sources, we ma
From a control design point of view, modern diesel engines are dynamic, nonlinear, MIMO systems. This paper presents a method to find low-complexity black-box dynamic models suitable for model predictive control (MPC) of NOx and soot emissions based on on-line emissions measurements. A four-input-five-output representation of the engine is considered, with fuel injection timing, fuel injection dur
The current monolithic and lengthy scheme behind the standardization and the design of new video coding standards is becoming inappropriate to satisfy the dynamism and changing needs of the video coding community. Such a scheme and specification formalism do not enable designers to exploit the clear commonalities between the different codecs, neither at the level of the specification nor at the le
Traditionally, diesel engine control has had to rely on indirect feedback variables and empirical open-loop maps because direct measurements of the variables representing high-level objectives, such as emissions, have not been available in production engines. With new sensors being developed, the opportunity opens to design the controller directly based on high-level objectives. In this paper, we
