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Seventy-four addictive alcoholic subjects were investigated shortly after a period of excessive drinking and were compared with 18 alcoholic subjects who had not been drinking for at least six months. No difference was observed in total white cell count or number of circulating granulocytes. Lymphocyte count was significantly lower in alcoholics whose last alcoholic bout had been three months or m
Neurodegenerative disorders (NDDs) such as Huntington's disease (HD) and the spectrum of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by progressive loss of selectively vulnerable populations of neurons. Although often associated with motor impairments, these NDDs share several commonalities in early symptoms and signs that extend beyond motor dysfunction
The engram encoding the interval between the conditional stimulus (CS) and the unconditional stimulus (US) in eyeblink conditioning resides within a small population of cerebellar Purkinje cells. CSs activate this engram to produce a pause in the spontaneous firing rate of the cell, which times the CS-conditional blink. We developed a Bayesian algorithm that finds pause onsets and offsets in the r
he effect of viscosity on the nasal absorption and biological response to desmopressin was studied in humans. Nasal solutions of desmopressin with and without the addition of 0.25% (w/v) methylcellulose were administered by a precompression nasal spray pump to 10 volunteers. Plasma levels of desmopressin were assayed by radioimmunoassay and the biological response was measured by determination of
Despite the rapidly expanding literature on agency in regional development, the methodological approaches available to study it have not followed theoretical development and empirical studies. This article aims to shed light on methodological issues related to the study of path dependence, path creation and agency. The article’s main purpose is to construct a methodology - path tracing - that woul
This work presents estimates of the emissions resulting from the production of white sugar and its by-products (molasses, pressed beet pulp and dried beet pulp) from sugar beet cultivation to the final product at the factory gate. The study covers the impact of global warming potential, eutrophication potential (freshwater and marine) and particulate matter. The analysis was based on detailed prim
How best to understand the responses of the European Community's member states to the new conditions prevailing in Europe at the end of the Cold War?The book claims that the beliefs behind symbolic agreements provide a greater understanding of European integration than a focus on the material motivations of agreements of substance. It breaks new ground by arguing that intergovernmental cooperation
Huntington’s disease is caused by a mutation in the gene that codes for the protein huntingtin (HTT). A therapeutic strategy for Huntington’s disease is to lower the levels of huntingtin in the brain. However, multiple clinical trials have been stopped due to adverse effects. This indicates that there is still a lot that we do not understand about huntingtin. Similarly to other neurodegenerative d
Context. The Gaia-ESO Survey (GES) is a large public spectroscopic survey that was carried out using the multi-object FLAMES spectrograph at the Very Large Telescope. The survey provides accurate radial velocities, stellar parameters, and elemental abundances for ~115 000 stars in all Milky Way components. Aims. In this paper, we describe the method adopted in the final data release to derive lith
In this article, I challenge the increasing emphasis on digital technologies to enhance encounters with the past in heritage landscapes. Beginning with a memory from my childhood, I conceptualise presence as being there and review recent approaches in heritage studies that highlight the wide range of benefits derived from embodied experiences in heritage places including reinforcing feelings of we
Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with substantial costs which increase with progression state. However, few studies have investigated the association between costs and health related quality of life. Objectives: To estimate the relationship between costs and health related quality of life, measured by the Parkinson's disease Quality of Lif
We report the discovery of a new ultra-short-period planet and summarize the properties of all such planets for which the mass and radius have been measured. The new planet, K2-131b, was discovered in K2 Campaign 10. It has a radius of and orbits a G dwarf with a period of 8.9 hr. Radial velocities obtained with Magellan/PFS and TNG/HARPS-N show evidence for stellar activity along with orbital mot
Syfte: Uppsatsens syfte är att kvalitativt tydliggöra och förstå skillnader i konsumenters lojalitetsgrad och köpbeteende, kopplat till service, mellan Generation Y och Baby Boomers och på så sätt bidra till service- och generationsforskningen. Metod: En kvalitativ studie med ett hermeneutiskt fenomenologisk förhållningssätt har genomförts. Forskningsansatsen är deduktiv med induktiva inslag. PrPurpose: The aim is to qualitatively distinguish and understand differences in purchase behavior and loyalty, related to service, between Generation Y and Baby Boomers and thus contribute to the service and generational research. Methodology: A qualitative study has been executed with a hermeneutic phenomenological approach. The research approach is deductive while also containing inductive eleme
The objective for this master thesis has been to develop a mathematical model of the actuator parts of the fifth generation Haldex AWD system. The parts to be modeled are the DC-Machine and the pump. Also a model of the elasticity of the clutch has to be derived as well as a model for the hydraulic fluid. These models were then to be implemented in Matlab Simulink. The model was derived by means o
The purpose of this study is to investigate the influencing factors on underpricing in the UK and Germany. The focus hereby lies on the different institutional framework (common and civil law) and implied ownership structure of both countries. A quantitative analysis is conducted using multiple linear regression model and descriptive statistics. The dependent variable underpricing is regressed on
For Chinese economy, the relationship between ownership and company performance is an important theoretical and practical topic. My research question is how ownership affect company performance and what is the basis determinant. In the view of macro, it relates to whether the economy system need further reform or not and if the economy could remain a sustainable growth. In the view of micro, it re
The aim of this thesis is to analyze what effect different aspects of globalization have had on gender equality in welfare and work life during the period 1970-2012 using data for up to 171 countries. The KOF index of globalization is used as a proxy to include social, political and economic globalization. Furthermore, gender equality is measured by relative changes in health, education and workfo
