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Background: Patients with unprovoked first venous thromboembolism (VTE) are at a high risk of recurrence. Although circulating microRNAs (miRNAs) have been found to be associated with VTE and are markers of hypercoagulability, this study is the first to examine whether circulating miRNAs are associated with the risk of VTE recurrence. Results: A nested case-control study design was used where plas
Objectives To assess 2-year durability of joint contracture correction following collagenase injections for Dupuytren's disease. Design Prospective cohort study. Setting Orthopaedic Department in Sweden. Participants Patients with palpable Dupuytren's cord and active extension deficit (AED) ≥30° in the metacarpophalangeal (MCP) and/or proximal interphalangeal (PIP) joint. A surgeon injected 0.80 m
Transient cerebral ischemia in normoglycemic animals is followed by a decrease in glucose utilization, reflecting a postischemic cerebral metabolic depression and a reduction in the activity of the pyruvate dehydrogenase complex (PDHC). Preischemic hyperglycemia, which aggravates ischemic brain damage and invariably causes seizure, is known to further reduce cerebral metabolic rate. To investigate
Both genetic and lifestyle factors contribute to the risk of non-alcoholic steatohepatitis (NASH). Additionally, epigenetic modifications may also play a key role in the pathogenesis of NASH. We therefore investigated liver DNA methylation, as a marker for epigenetic alterations, in individuals with simple steatosis and NASH, and further tested if these alterations were associated with clinical ph
AbstractThe degradation of plant based β-mannan polysaccharides represents one of the many challenges efficiently tackled by microorganisms living in different habitats. In this thesis, glycoside hydrolases (GHs) involved in mannan degradation from two different organisms, Aspergillus nidulans (paper I and II) and Bacteroides ovatus (paper III and IV) were studied. A. nidulans is a saprophytic fun
BACKGROUND. Radiotherapy is a known risk factor for sarcoma development. Postirradiation sarcomas arise within the radiation field after a latency period of several years and usually are highly malignant. Very little is yet known about their genetic changes. METHODS. Twenty-seven postirradiation sarcomas were analyzed by comparative genomic hybridization, which allows genome-wide screening of DNA
BACKGROUND: Decreased glomerular filtration rate is an established risk factor for bleeding but there are limited data on its association with bleeding risk in well-controlled anticoagulated patients taking warfarin. OBJECTIVES: The aim was to investigate the relationship between glomerular filtration rate, major bleeding and thromboembolic complications in patients with tight anticoagulation cont
Popular Abstract in Swedish Många åtminstone i min generation kommer säkert ihåg att de under gymnasiets biologilektioner fick lära sig att vatten diffunderade fritt över cellens membran ? osmos och fri diffusion var ledorden. Jag vet inte hur läroböckerna är utformade idag, men efter att Nobelpriset i kemi år 2003 tilldelades Peter Agre för upptäckten av att aquaporiner fungerar som vattenkanalerIn order to identify integral and peripheral proteins associated with the plasma membrane (PM), highly purified Arabidopsis PMs were analyzed by mass spectrometry. In total, 238 putative PM proteins were identified, of which 114 were predicted to have transmembrane domains or to be PM-anchored. Identified proteins were involved in transport, signal transduction, membrane trafficking and stress res
Popular Abstract in Swedish Vid extern strålbehandling används en s.k. linjäraccelerator för att producera och leverera den önskade strålningen till cancertumörer. I linjäracceleratorn accelereras elektroner till nära ljusets hastighet och styrs sedan mot en metalplatta där de bromsas upp och genererar bromsstrålningsfotoner (högenergetisk röntgenstrålning). Intensiteten av den strålning som sändsThe aim of this work was to investigate the dosimetric effects of removing the flattening filter from conventional C-arm medical linear accelerators. In conventional linear accelerators used for radiotherapy, a flattening filter is positioned in the beam line to provide a uniform lateral dose profile at a specified depth in water. However, for some radiotherapy treatments, a uniform lateral dose p
Vitamin D supplements have been used to prevent fractures. The effect may be mediated through increased bone mass, but also through reduced falling propensity. The aim of this study was to evaluate the association between 25-hydroxy vitamin D levels (25OHD), fall-associated variables (including tests of functional performance), and fracture in ambulatory women. At baseline 25OHD was measured in 98
A multicenter, open-label, randomized efficacy and safety study was performed with combined human chorionic gonadotropin (hCG) and recombinant follicle-stimulating hormone (recFSH) (Puregon(R)) treatment to induce spermatogenesis in hypogonadotropic hypogonadal male patients. Patients were pretreated for 16 weeks with hCG to normalize testosterone levels. A total of 30 of 49 (61%) subjects had nor
A bench scale aerobic submerged membrane bioreactor (ASMBR) was used to treat diluted palm oil mill effluent (POME). For further improving the effluent quality and reduction of bio-fouling, powdered activated carbon (PAC) and zeolite were used as bio-fouling reducers (BM). We compared the performances of ASMBR without BFR (called BFR0) with ASMBR using BFR, namely 2 g/L PAC (BFR1), 4 g/L PAC (BFR2
Apolipoprotein M (apoM) is a 188 amino acid, 25 kDa protein belonging to the lipocalin protein superfamily. Although predominantly associated with high density lipoprotein, apoM is found in all major lipoprotein classes. To facilitate clinical studies of apoM, we have developed a sandwich ELISA for the measurement of apoM in human plasma. This method has been used to investigate normal apoM variat
Background: The US Environmental Protection Agency voluntary phased-out residential use of chlorpyrifos in 2001. In contrast, in Costa Rica, chlorpyrifos-treated bags are increasingly used to protect banana and plantain fruits from insects and to fulfill product standards, even in populated areas. Objectives: To evaluate children's exposure to chlorpyrifos in villages situated nearby banana planta
Our knowledge about acute promyelocytic leukemia (APL) patients is mainly based on data from clinical trials, whereas population-based information is scarce. We studied APL patients diagnosed between 1997 and 2006 in the population-based Swedish Adult Acute Leukemia Registry. Of a total of 3897 acute leukemia cases, 3205 (82%) had non-APL acute myeloid leukemia (AML) and 105 (2.7%) had APL. The in
Popular Abstract in Swedish Eftersom allt i och runt oss består av kemikalier är det av högsta vikt att vi förstår hur dessa reagerar med varandra. Katalytiska omvandlingar är kemiska reaktioner där en katalysator underhåller en reaktion utan att själv förbrukas. Inom metallorganisk kemi är tillverkning och förstålelsen av hur komplex med övergångsmetaller kan användas vi katalys mycket viktig. KoAbstract The work presented in this thesis discusses synthesis of PCP-complexes and utilisations of such organometallic compounds in catalysis. The complexes, obtained by intramolecular Csp3-H activation, are based on the metals palladium, platinum and iridium. The synthesis of PCP-ligands include new and improved preparative routes to the previously known cis-1,3-bis-(di-iso-propylphosphinito)cy
BACKGROUND: Pulmonary embolism (PE) is a severe condition with nonspecific symptoms. Diagnosis relies on medical imaging but follow-up is currently based on clinical symptoms and general risk factors. The duration of anticoagulant treatment after an acute episode of PE is still subject to debate and the best method of identifying the risk of recurrence in individual patients is undefined. Tomograp
This study seeks, with an internet based survey containing ten pages taken from five different manga, to identify if people who read manga (Japanese comics) absorb every part of a presented manga page. It will attempt to see how well they understand various aspects of the Japanese language and what the readers focus lies on within each page, as well as touch upon the subject of using manga as a to
PROPERTY TAX MAPPING, ASSESMENT & MONITORING USING GIS Property tax recovery is considered one of the most challenging tasks for governments around the globe in general and in third world countries including Pakistan, India, and Sri Lanka in particular. Today, the existing real property assessment and tax collection system are under pressure to increase its efficiency. Moreover, monitoring anProperty Tax Mapping and Assessment Using GIS Property tax recovery has remained one of the challenging tasks over the years for almost every government around the world, especially in third-world countries. Today, the existing property assessment and tax collection system in Pakistan is antique and defective in many ways and is under pressure to increase its efficiency and tax revenue. Tax asse
Purpose: This thesis purpose is to see how pharmaceutical companies can use the Transaction Cost Economics theory in their decision making in regards to the make, buy or ally decision when a new market emerges. Method: This is a basic case study that focuses on the pharmaceutical company AstraZeneca. It has an idiographic approach, and several semi-structured interviews have taken place. Pattern-
