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Feasibility of adaptive SBRT of prostate cancer: Investigating uncertainties in AI-driven and CBCT-guided online adaptive radiotherapy

Cancer kan drabba vem som helst och kan ha sitt ursprung i många olika områden i kroppen. Antalet nya cancerfall ökar varje år, men vissa typer av cancer har bättre prognos än andra. Den vanligaste cancertypen i Sverige är prostatacancer och den drabbar framför allt äldre män. Prostatacancer har god prognos och det finns effektiva metoder att helt bota prostat- acancer om den behandlas i ett tidigPurpose: Recent developments in external radiotherapy and its utilization with artificial in- telligence (AI) enables advanced treatment plans for a range of different disease sites. By adapting to the anatomy of the day, target coverage can be ensured while sparing more healthy tissue. The purpose of this project was to study the feasibility and benefits of daily cone beam computed tomography (CB

Att hjälpa utan att stjälpa - Ofrivillighetsbedömningen vid våldtäktsbrott när målsäganden har en psykisk funktionsnedsättning

Aktuell uppsats undersöker de rättsliga utgångspunkterna och bedömningarna av ett ofrivilligt deltagande i våldtäktsfall där målsäganden har en psykisk funktionsnedsättning. Målsäganden som har psykiska funktionsnedsättningar (i uppsatsen: intellektuell- och neuropsykiatriska funktionsnedsättningar) har större svårigheter att uttrycka sig och förstå andra människors kommunikationer, vilket gör This essay examines the legal framework and the legal assessments regarding involuntary sexual acts in rape cases when the plaintiff has a mental disability. People with mental disabilities (here: intellectual- and neuropsychological disabilities) have greater difficulties expressing themselves and understanding other people, which puts them at greater risk of being sexually abused. Both Swedis

Riskmodell för utökat underhållsintervall på ångturbiner

The purpose of this project was to create a risk model for extended time between major overhauls on steam turbines. The project was created by Siemens Industrial Turbomachinery who develops and manufactures steam turbines and performs maintenance. It is the turbine users who have requested a longer time in order to reduce maintenance costs and increase availability. Prior to the work, external and

Tankar kring scatsång och röstimprovisation - en studie av erfarna jazzsångares uppfattningar om scatsång och röstimprovisation

Scatsång och röstimprovisation är speciella kännetecken som skiljer jazzsång från andra sångstilar. Men det betyder inte att alla jazzsångare gillar att sjunga scatsång eller göra ordlösa improvisationer med sin röst. Vilka tankar finns hos jazzsångare om scatsång och röstimprovisation? Det är en fråga som har inspirerat mig till att göra denna studie. Syftet med denna studie är alltså att undersö

Objektivitet i socialt arbete

Swedish law is very keen on the fact that every person should be treated equal when facing the legal system. When it comes to cases concerning children, social workers and judges are expected to strictly obey the rules of the law but at the same time make individual judgements based on the best interest of the child, something that requires a great deal of empathy and knowledge. Is it possible to

Starta samverkan uppifrån? En rättssociologisk studie av makrostyrning, samverkan och normbildningsprocesser

The purpose of the master thesis has been to investigate the professional experiences of collaboration within the framework of the agreement on cooperation for greater security in the city of Landskrona and further investigate the macro-control and prospective norm formation processes between the police and city. Of the mission statement it is clear that the focus should be on processes and not on

Måste man samtycka till samlag? - En studie av en samtyckesreglerings för- och nackdelar med en medial utblick

Sexualbrotten i svensk rätt kräver idag att gärningsmannen har använt någon typ av våld eller hot, eller har utnyttjat ett hjälplöst tillstånd. År 2003 kom emellertid Europadomstolens avgörande i Bulgariendomen, i vilken kan utläsas att varje sexuell handling som begås utan samtycke ska vara straffbar. Sedan dess har det i Sverige livligt debatterats om huruvida domen innebär att den svenska lagenThe sexual offences in Swedish law of today require that the perpetrator has used violence or threats, or that he has exploited a helpless state. However, in 2003 the European Court of Human Rights delivered a judgment in the case of M.C v. Bulgaria, which stated that any non-consensual sexual act must be punishable. There has been a legal discussion in Sweden ever since, regarding whether this ju

Dialektisk beteendeterapi: en undersökning av behandlingens effektivitet

Syftet med föreliggande studie är att evaluera patienters erfarenheter av att ha genomgått Dialektisk beteendeterapi (DBT) vid en specia-listmottagning inom vuxenpsykiatrin. Dialektisk beteendeterapi för borderline personlighetsstörning, utvecklad av Marsha Linehan är speciellt utformad för klinisk behandling av kroniskt suicidala patien-ter med borderline personlighetstörning. Forskning kring DiaThe purpose of this study was to evaluate patients´ experiences of being subjected to Dialectical behavior therapy (DBT) in a specialized out-patient psychiatry unit in a South Swedish town. DBT, developed by Marsha Linehan, is specifically designed for clinical treatment of chronically suicidal patients with borderline personality disorder. Re-search on dialectical behavior therapy, its design an

Correcting for Systematic Underestimation of Topographic Glacier Aerodynamic Roughness Values From Hintereisferner, Austria

Spatially-distributed values of glacier aerodynamic roughness (z0) are vital for robust estimates of turbulent energy fluxes and ice and snow melt. Microtopographic data allow rapid estimates of z0 over discrete plot-scale areas, but are sensitive to data scale and resolution. Here, we use an extensive multi-scale dataset from Hintereisferner, Austria, to develop a correction factor to derive z0 v

Neoadjuvant Trastuzumab, Pertuzumab, and Docetaxel vs Trastuzumab Emtansine in Patients with ERBB2-Positive Breast Cancer : A Phase 2 Randomized Clinical Trial

Importance: Trastuzumab emtansine (T-DM1) is presently approved for treatment of advanced breast cancer and after incomplete response to neoadjuvant therapy, but the potential of T-DM1 as monotherapy is so far unknown. Objective: To assess pathologic complete response (pCR) to standard neoadjuvant therapy of combination docetaxel, trastuzumab, and pertuzumab (DTP) vs T-DM1 monotherapy in patients

Engineering the Oxidative Potency of Non-Heme Iron(IV) Oxo Complexes in Water for C-H Oxidation by a cis Donor and Variation of the Second Coordination Sphere

A series of iron(IV) oxo complexes, which differ in the donor (CH2py or CH2COO-) cis to the oxo group, three with hemilabile pendant donor/second coordination sphere base/acid arms (pyH/py or ROH), have been prepared in water at pH 2 and 7. The νFe=O values of 832 ± 2 cm-1 indicate similar FeIV=O bond strengths; however, different reactivities toward C-H substrates in water are observed. HAT occur

Digital Tools in Supplemental Instruction (SI)

This study focus on digital tools and software programmes used in SI. It combines a case study for the SI programme at Lund University with an international overview. The digital tools are divided in categories based on where they are used in SI. Digital tools for SI leaders are usually tools for communication with participants between sessions (Facebook, Messenger, WhatsApp, etc.); sharing good p

Association of Sleep Duration with All- And Major-Cause Mortality among Adults in Japan, China, Singapore, and Korea

Importance: The association between long sleep duration and mortality appears stronger in East Asian populations than in North American or European populations. Objectives: To assess the sex-specific association between sleep duration and all-cause and major-cause mortality in a pooled longitudinal cohort and to stratify the association by age and body mass index. Design, Setting, and Participants

Spectroscopic differences in posterior insula in patients with chronic temporomandibular pain

Chronic pain including temporomandibular disorder (TMD) pain involves a complex interplay between peripheral and central sensitization, endogenous modulatory pathways, cortical processing and integration and numerous psychological, behavioral and social factors. The aim of this study was to compare spectroscopic patterns of N-Acetyl-aspartate (NAA), total creatine (tCr), choline (Cho), myo-inosito

Lévy-stable two-pion Bose-Einstein correlations in s NN =200 GeV Au+Au collisions

We present a detailed measurement of charged two-pion correlation functions in 0-30% centrality sNN=200 GeV Au+Au collisions by the PHENIX experiment at the Relativistic Heavy Ion Collider. The data are well described by Bose-Einstein correlation functions stemming from Lévy-stable source distributions. Using a fine transverse momentum binning, we extract the correlation strength parameter λ, the

Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial

Background: Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurrent stroke compared with antiplatelet therapy. We hypothesised that anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, would reduce the risk of recurrent ischaemic stroke compared with as

Amperometric detection of lactose using -galactosidase immobilized in layer-by-layer films

A direct, low-cost method to determine the concentration of lactose is an important goal with possible impact in various types of industry. In this study, a biosensor is reported that exploits the specific interaction between lactose and the enzyme β-galactosidase (β-Gal) normally employed to process lactose into glucose and galactose for lactose-intolerant people. The biosensor was made with β-Ga

Comparison of plasma ALZpath p-Tau217 with Lilly p-Tau217 and p-Tau181 in a neuropathological cohort

There is an urgent need for accurate and validated methods to measure plasma phosphorylated tau (p-Tau) biomarkers in Alzheimer’s disease (AD). In this study, we compared the performance of new commercially available plasma p-Tau217 assay developed by ALZpath to other established p-Tau assays in an autopsy-confirmed sample. We included 72 participants from the Arizona Study of Aging and Neurodegen

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not i

Can 177Lu-DOTATATE Kidney Absorbed Doses be Predicted from Pretherapy SSTR PET? Findings from Multicenter Data

Before performing 177Lu-DOTATATE therapy for neuroendocrine tumors, somatostatin receptor (SSTR) PET imaging is currently used to confirm sufficient tumor SSTR expression, but it also has potential to be used to personalize treatment by predicting absorbed doses to critical organs. This study aims to validate the predictive capability of SSTR PET in anticipating renal absorbed dose in the first cy