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Aspects of 18F-PSMA-1007 PET/CT in prostate cancer : Biokinetics, dosimetry, protocol and diagnostic accuracy

Overview: Prostate cancer (PC)is the most common cancer in Sweden, and the leading cause of cancer death. Positronemission tomography with x-ray computed tomography (PET/CT) is an important imagingmethod for many cancers. A group of PET radiopharmaceuticals known as PSMA(prostate specific membrane antigen) ligands has been introduced for imaging ofPC. This thesis investigates aspects of the ligand

Decision-making of employees in tech-driven R&D: An exploratory study on effectuation theory within the Fuzzy Front End of Innovation.

Problem - Uncertainty greatly burdens innovation in tech-driven industries which has made decision-making an art-like navigation, especially within the Fuzzy Front End of operations. This has motivated previous researchers to study the effectual decision-making principles originated by Sarasvathy in regard to a wide variety of audiences such as entrepreneurs, start-ups and top management. Employee

Non-diegetic film music as a narrative agency in Christopher Nolan's Interstellar (2014)

This study sets out to investigate the non-diegetic music in Christopher Nolan’s Interstellar (2014) in order to highlight its implicit narrative functions and meanings. The theoretical approach consists of semiotic concepts such as ‘Cognitive denotative’ and ‘Cognitive connotative’ functions by Emilio Audissino, ‘Myth’ and ‘Anchorage’ by Barthes as well as Claudia Gorbman’s ‘Connotative Cueing’.

On stock return prediction with LSTM networks

Artificial neural networks are, again, on the rise. The decreasing costs of computing power and the availability of big data together with advancements of neural network theory have made this possible. In this thesis, LSTM (long short-term memory) recurrent neural networks are used in order to perform financial time series forecasting on return data of three stock indices. The indices are S&P

Avrinningskoefficienten – dess relation till regnintensitet och bidragskoefficienten utifrån fallstudier i södra Sverige

För att se vilken inverkan regnets intensitet har på avrinningskoefficienten gjordes en litteraturstudie samt beräkningar i Excel. Litteraturstudien visar att de tabellerade värdena på avrinningskoefficienten är framtagna genom en undersökning där ett formulär sändes ut till privata och offentliga kontor i USA där de angav vilka värden på avrinningskoefficienten de brukar använda. Resultatet är prIn order to increase the knowledge regarding how the runoff coefficient varies with increased rainfall intensity, a literature study and calculations in Excel were conducted. The background to how the tabled values of the runoff coefficient have been determined was found to be a book based on an assembly of answers to a survey collected from different companies in USA. The book is called Design an

Barn som anhörig. Barns rätt till information, stöd och hjälp vid förälders missbruk eller psykisk ohälsa i lag och tillämpning

Denna framställning syftar till att lyfta fram gruppen barn som anhöriga i rampljuset. Som led i detta kommer det att redogöras för hur barns väg från objekt till subjekt påverkat barns rättigheter och särskilt rätten att få information stöd och hjälp vid förälders missbruk eller psykisk ohälsa. För att kunna ge en mer fullständig bild av detta problem har även tillämpningen av dessa eventuella reThis essay seeks to bring children with parents suffering from addiction problems or mental illnesses to the public attention. In order to do this I have to examine how the view of children within the legal system has changed, from being an object to being a subject, and how this has affected children’s rights to receive information, support and help when one or both parents suffer from addiction

Migrationsdomstolarnas utredningsansvar med fokus på landinformation i asylärenden

Rätten till asyl utgör en av de grundläggande mänskliga rättigheterna och den garanterar att en asylsökande ska få frågan om sin flyktingstatus prövad i ett förfarande med visa garantier. Beslut i asylärenden är av stor betydelse för den enskildes liv och felaktiga beslut kan medföra allvarliga kränkningar av den enskildes mänskliga rättigheter. Inom asylrätten gäller som grundläggande princip attThe right of asylum is one of the fundamental human rights which guarantees that a person who seeks asylum will have his or hers status as a refugee, tried with some guarantees. Decisions made in an asylum case are of great importance for the individual and wrong decisions can lead to serious violations of the individual’s human rights. Within the asylum law is a fundamental principle which states

Estimating expected lifetime of revolving credit facilities in an IFRS 9 framework

This paper sets out to estimate expected lifetime of revolving credit facilities (e.g. credit card products) and is motivated by the introduction of the International Financial Reporting Standard 9 (IFRS 9) and its requirements for loan impairments. The reporting entity is required to estimate lifetime expected credit losses for certain nancial instruments. In practice, maximum contractual period What period should credit losses be estimated over in IFRS 9? When the standard on how to account for credit losses moves to an expected loss approach, there is a need to find out how far into the future to look for losses. This is known as the expected lifetime, and I have dived into interpreting how the IFRS 9 standard can be implemented in a model for expected lifetime for credit cards and simi

Handlingsoffentlighet och sekretess vid offentlig upphandling

Den offentliga sektorn är en stor aktör på många olika marknader. Offentliga inköp görs varje år för betydande summor i Sverige. Det offentliga upphandlingsförfarandet styr dessa inköp och regleras framförallt i LOU. Ett upphandlingsförfarande bygger på tanken att låta leverantörer konkurrera om offentliga kontrakt på ett öppet, likvärdigt och konkurrensneutralt sätt. De svenska upphandlingsbestämThe public sector is a major operator on numerous different markets. In Sweden public purchases are made for great amounts every year. The public procurement procedure is governing these purchases and is mainly regulated in LOU. A procurement procedure is based on the idea to let contractors compete for public contracts in an open, equal and competitively neutral way. The Swedish public procuremen

Bilirubin-A Potential Marker of Drug Exposure in Atazanavir-Based Antiretroviral Therapy

The objective of this work was to examine the atazanavir-bilirubin relationship using a population-based approach and to assess the possible application of bilirubin as a readily available marker of atazanavir exposure. A model of atazanavir exposure and its concentration-dependent effect on bilirubin levels was developed based on 200 atazanavir and 361 bilirubin samples from 82 patients receiving

First Observation of the Decay of a 15- Seniority v=4 Isomer in 128Sn

Isomeric states in the semimagic Sn128-130 isotopes were populated in the fragmentation of a Xe-136 beam on a Be-9 target at an energy of 750 A.MeV. The decay of an isomeric state in Sn-128 at an excitation energy of 4098 keV has been observed. Its half live has been determined to be T-1/2 = 220(30) ns from the time distributions of the delayed gamma rays emitted in its decay. gamma gamma coincide

Chemical and Morphological Characterisation of Aerosol Particles in the Tropopause Region

Popular Abstract in Swedish Små partiklar i form av vätska eller fast material mellan 0.001 till 100 µm i diameter, kan sväva i luften och kallas då aerosolpartiklar. De påverkar direkt på klimatet genom att reflektera solstrålar ut till rymden. Detta gör att vi får ett kallare klimat. Indirekt kan de påverka klimatet genom att verka som kondensationskärnor vid molnbildning. Med detta påverkar de The aim of this work was to study atmospheric aerosols, focusing on the chemical composition, the morphology and the origin of the aerosol in the upper troposphere and lowermost stratosphere. An aerosol sampler was developed for this purpose. A new method for quantitative analysis of the major components of the aerosol, i.e. C, N and O was developed, and methodologies for single-particle analysis

In-Plane Fracture of Paper

Popular Abstract in Swedish Pappersbrott i planet har studerats med hjälp av den kohesiva sprick modellen ur ett experimentellt såväl som ur ett teoretiskt perspektiv. Brott i en pappersremsa erhålls när remsan i en provmaskin belastas till sin maximala bärlast. Om remsan är tillräckligt kort fås en stabil nedåtgående last-förlängnigs kurva efter det att max lasten är nådd. Det visade sig att denThe in-plane failure of paper is studied in this work by means of a cohesive crack model from experimental as well as theoretical perspectives. Localized damage at in-plane tension of short paper strips is studied for low strain rates. It is observed that under uniaxial in-plane tensile tests, the evolution of the failure is stable and the damage of the paper strip is localized into a narrow zone

Progress in treatment and risk stratification of neuroblastoma: Impact on future clinical and basic research.

Close international collaboration between pediatric oncologists has led to marked improvements in the cure of patients, seen as a long-term overall survival rate of about 80%. Despite this progress, neuroblastoma remains a challenging disease for both clinicians and researchers. Major clinical problems include lack of acceptable cure rates in high-risk neuroblastoma and potential overtreatment of

Spectroscopic Investigations of Highly Charged Tungsten Ions - Atomic Spectroscopy and Fusion Plasma Diagnostics

Popular Abstract in Swedish Atomspektra har varit ett viktigt forskningsområde inom fysiken sedan mitten av 1800-talet. Då elektromagnetisk strålning, såsom synligt ljus, ultraviolett- och röntgenstrålning, är unik för varje grundämne ger ett observerat spektrum information om vilka slags atomer som emitterar strålningen. Exempelvis så visar spektra av ett vanligt lysrör att ljuset kommer från kviThe spectra of highly charged tungsten ions have been investigated using x-ray and extreme ultraviolet spectroscopy. These heavy ions are of interest in relativistic atomic structure theory, where high-precision wavelength measurements benchmark theoretical approaches, and in magnetic fusion research, where the ions may serve to diagnose high-temperature plasmas. The work details spectroscopic in

The European Multiple System Atrophy-Study Group (EMSA-SG)

Introduction. The European Multiple System Atrophy-Study Group (EMSA-SG) is an academic network comprising 23 centers across Europe and Israel that has constituted itself already in January 1999. This international forum of established experts under the guidance of the University Hospital of Innsbruck as coordinating center is supported by the 5th framework program of the European Union since Marc

Cardiovascular Risk Genes in Prevention and Treatment Response

GENERAL AIM: To investigate how common single-nucleotide-polymorphisms (SNPs) that associate with cardiovascular disease (CVD) could be used in prevention and treatment of CVD. SUBJECTS: Subjects from the population-based Malmö-Diet-and-Cancer-(MDC)-Study (n=30447) and hypertensives from the Nordic-Diltiazem-(NORDIL)-Study (n=10881). METHODS AND RESULTS: A nine-SNP-lipid-genetic-risk-score was r

On the mechanisms that limit oxygen uptake during exercise in acute and chronic hypoxia: role of muscle mass

Peak aerobic power in humans ((V) over dot(O2), peak) is markedly affected by inspired O-2 tension (F-IO2). The question to be answered in this study is what factor plays a major role in the limitation of muscle peak. (V) over dot(O2) in hypoxia: arterial O-2 partial pressure (P-a,(O2)) or O-2 content (C-a,C-O2)? Thus, cardiac output (dye dilution with Cardio-green), leg blood flow (thermodilution

Alpha-1-microglobulin, heme-binding protein, reductase and antioxidant

Popular Abstract in Swedish Alla levande organismer består av celler som tillsammans med molekyler generellt kallade extracellulär matrix bildar en vävnad. Celler innehåller fyra huvudgrupper av byggstenar: socker, fettsyror, aminosyror och nukleotider, vilka i tur och ordning bildar kolhydrater, fetter, proteiner och nukleinsyror. I vävnaderna pågår en ständig omsättning av byggstenarna och molek

Maskrosen bröt sig väg ändå : En studie av copingstrategier och skyddsfaktorer hos bloggare som skriver om en svår barndom

As a social worker you often meet children that are exposed to harmful environments in one way or another. Children who grow up in these circumstances could easily be forgotten, there-fore it is vital that these children are brought to attention. In these situations it´s necessary to find which positiv measures would be benefitial for these children. The internet is an expan-sive resource due to t