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Background: A varying response to cholinesterase inhibitor (ChEI) treatment has been reported among patients with Alzheimer’s disease (AD). Whether the individual-specific response directly affects time to nursing home placement (NHP) was not investigated. Objective: We examined the relationship between the 6-month response to ChEI and institutionalization. Methods: In a prospective, observational

There is a lack of knowledge on mentally disordered sex offenders (MDSOs) targeting adult victims, especially regarding recidivism patterns and the specific subgroup with psychiatric disorders. This paper presents index offense data, clinical data, and recidivism patterns over up to 24 years in a cohort of 146 MDSOs, with and without psychotic disorders, sentenced in Sweden between 1993 and 1997.

The disorders of serine biosynthesis are a group of inborn errors of metabolism characterised by congenital microcephaly, seizures and severe psychomotor retardation. Although these disorders are rare the prompt recognition of serine deficiency is important as these disorders are treatable. The diagnosis is based on decreased concentrations of serine in cerebrospinal fluid (CSF). It has previously

Introduction: Elderly patients with displaced femoral neck fractures (FNF) are usually operated with arthroplasty but with various combinations of implants and approaches. Thus, the optimal treatment is still controversial. We aimed to compare the results between the cemented bipolar hemiarthroplasty (HA) and total hip arthroplasty (THA) patients operated for FNF regarding revision rate at 1 year

Renal Fanconi syndrome developed rapidly in a 3-year-old Moroccan girl with established lysinuric protein intolerance. She was hospitalized because of lowered consciousness, uncoordinated movements and hepatosplenomegaly after a febrile period. Laboratory investigations revealed plasma ammonia 270 micromol/L (normal <70 micromol/L), ferritin 159 micromol/L (normal 2-59 micromol/L), LDH 1180 U/L (n

INTRODUCTION: Variants in collagen-related genes COL1A1, COL3A1, COL5A1 andCOL5A2 are associated with Ehlers-Danlos syndrome (EDS), a heterogeneous groupof connective tissue disorders strongly associated with increased bleeding. Of patientswith incompletely explained bleeding diathesis, a relatively high proportion were shown to harbour at least one heterozygous variant of unknown significance (VU

Denna uppsats syftar till att utreda vilken betydelse erkännandet har i brottmålsprocessen i Sverige. Uppsatsens fyra frågeställningar utgör ramen, och innefattar såväl en allmän del om bevisprövning som en djupdykning i erkännandets prövning och styrka som bevis. I uppsatsen används huvudsakligen rättsdogmatisk metod. Dock görs även en undersökning av sex omtalade tingsrättsdomar för att se hur pThis essay aims to study the importance of confessions in Swedish criminal law procedure. The essay consists of a general overview of the court’s evaluation of evidence as well as an examination of how the courts perceive confessions and the strength of a confession as evidence. Six renowned district court rulings have been analyzed to see how the law is applied. Since this area is largely unregul

The now Swedish province of Scania has had a long history of violence and unrest, with several wars being fought on Scanian soil. Such tumultuous times must have impacted the common people and their living conditions, yet bioarchaeological research is lacking for post-medieval Scania and much of Sweden. By analysing a skeletal material from a 16-18th century semi-urban cemetery in Ängelholm, for w

Helicobacter pylori is an important pathogen inhabiting the human stomach. H. pylori binds plasminogen, a 90 kDa glycoprotein secreted by liver cells, and utilizes it for enhancing virulence. Surface receptors on the bacteria recognize plasminogen that is then activated into plasmin by host factors. The active plasmin can degrade a range of host proteins including proteins of the extracellular mat

The world is currently facing a number of large environmental challenges, and cleantech is pointed at to be one of the best potential answers. However, in the winds of a financial crisis, shifting capital markets and rapidly growing information technology sector, the cleantech segment currently finds itself in a disadvantaged situation where the direly needed early-stage capital is not finding its

Material science has become an important research area in order to fulfill today’s requirements on lighter, cheaper and more sustainable materials. The European spallation source is a research center based on the world’s most powerful neutron source, which will enable new possibilities to evaluate material properties down to an atomic level. The linear accelerator (Linac), accelerates with help of

Avtalsfriheten är en grundläggande rättsprincip inom avtalsrätten och fundamental för ett marknadsekonomiskt samhälle. Ett modernt samhälle kännetecknas emellertid också av regleringar och förbud. När får intresset för avtalsfrihet ge vika för andra samhällsintressen? Uppsatsen syftar till att klargöra vilka civilrättsliga rättsverkningar som följer av att ett avtal har slutits i strid med ett legFreedom of contract is a fundamental principle within contract law and is essential in a market economy. Our society today, however, is also characterized by regulations and prohibitions. When is the interest of freedom of contract forced to submit to other societal interests? This paper aims to clarify which legal consequences may follow when a contract is concluded in violation of a statutory pr

Sedan urminnes tider har man vetat om att det finns ljusa kroppar på himlen som rör sig ovanligt fort. Grekerna döpte dessa till vandrare, ett ord som på grekiska uttalas väldigt likt planet. Planeterna har studerats i århundraden och bara de senaste två decennierna har vi ökat från våra egna åtta planeter till flera tusen nya planeter kallade exoplaneter, planeter runt andra stjärnor än våran egeData from NASA's Kepler space telescope, which searches for exoplanets via the transit method, produced 1108 new planetary candidates in 2013 with a total of 91% being smaller than Neptune in size. These were mostly super-Earths, terrestial planets between Earth and Neptune in size, with orbits around 10 days. In order for any theory of planet formation to be valid it must be able to account

EU:s regelverk om offentlig upphandling uppdaterades 2014 och snart kommer uppdateringen i den svenska lagtexten. Det blir nu ännu tydligare att det är tillåtet att ställa miljökrav vid offentlig upphandling. Det är en vanlig uppfattning att det inte går att upphandla varor, tjänster och byggnadsverk med bättre miljöprestanda eftersom att de traditionellt sett inte kan konkurrera med kriteriet ”This is a master’s thesis about green public procurement (GPP) in the construction sector, based on a legal dogmathic study and a case study. The legal dogmathic part focused on both EU-legislation and on Swedish legislation. The case study was performed on the municipal of Lund to understand how a small authority works with GPP. The study of EU-legislation shows that the possibility to request b

För att dömas till straffansvar enligt svensk rätt krävs att gärningspersonen uppvisar skuld antingen i form av uppsåt eller oaktsamhet. Straffrättsligt ansvar för våldtäkt förutsätter enligt svensk rätt att gärningspersonen begår gärningen med uppsåt. I våldtäktsbrottmål kan en gärningsperson som misstar sig om en relevant omständighet och alltså begår gärningen utan uppsåt inte dömas till straffTo be held liable for a crime under Swedish law, the offender has to show guilt, either intentionally or through negligence. According to Swedish law, criminal liability for rape presupposes that the perpetrator has committed the act intentionally. In rape crime cases, an offender cannot be convicted if he or she is mistaken about a relevant circumstance and hence commits the act through negligenc

Förståelse av dynamiken i interaktionen mellan proteiner och olika molekyler kan underlätta designen av nya läkemedel mot till exempel cancer. Detta kan man studera i stora magneter med så kallad magnetresonansspektroskopi. I kroppen finns en proteinfamilj, Galektiner, som deltar i många biologiska processer. Ett av dessa protein, Galektin-3, är involverat i utvecklingen av cancer vilket gör att This master thesis consists of two parts, which both deal with NMR studies of the carbohydrate-binding domain of the protein galectin-3 (Gal3C). In the first part, 19F relaxation of two difluorinated diastereomeric ligands bound to Gal3C was analyzed with the model-free approach to extract information about the dynamics. The second part reports the assignments of the backbone amide 1H/15N resonanc

How can the low representation of women in politics in Bosnia-Herzegovina be understood and what can a different approach add to already existing approaches to make Bosnia-Herzegovina more gender equal in terms of political representation of the genders? There has been established a Gender Equality Law that demands a 40% gender quota of political representation, but the gender representation has o

Predictive archaeological modelling is a complex analytical process that requires the understanding of how complex environmental and anthropogenic spatial phenomena relate to the selection of archaeological site location and knowledge of the requirements and potential biases inherent in the method of modelling and the raw data itself. This paper aims to demonstrate the utility of the weights of ev