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PURPOSE: To examine the subsequent risk and prognosis of urological cancers among individuals diagnosed with autoimmune(AI) diseases. MATERIALS AND METHODS: We analyzed systematically the risk and prognosis of prostate, kidney and bladder cancers among individuals diagnosed with any of 33 different AI diseases based on nation-wide Swedish database covering years 1964 through 2008. Standardized inc
Introduction: Dead space negatively influences carbon dioxide (CO2) elimination, particularly at high respiratory rates (RR) used at low tidal volume ventilation in acute respiratory distress syndrome (ARDS). Aspiration of dead space (ASPIDS), a known method for dead space reduction, comprises two mechanisms activated during late expiration: aspiration of gas from the tip of the tracheal tube and
BACKGROUND Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic
Minimal residual disease (MRD) detection during the early treatment phase has become an important stratification parameter in many childhood acute lymphoblastic leukaemia (ALL) treatment protocols. Here, we aimed to address the applicability of rearranged antigen-receptor genes as potential MRD markers using real-time quantitative polymerase chain reaction (RQ-PCR) in a Swedish population-based co
HIV-1 is divided into different subtypes and circulating recombinant forms (CRFs) but the impact of HIV-1 subtype/CRF on disease progression is not fully understood. We determined the HIV-1 subtype/CRF of 152 seroincident individuals from Guinea-Bissau, based on the C2-V3 region of env. Rate of disease progression was measured as time from estimated seroconversion to AIDS and AIDS-related death. H
Abstract A fracture of the proximal interphalangeal (PIP) joint at the base of the middle phalanx is rare, but is a challenge to treat. Posttraumatic osteoarthritis is a known complication causing impaired hand function and disability. The aim of the present retrospective study was to evaluate characteristics and outcome of complex PIP joint fractures treated by the pins and rubbers traction syste
Sammanfattning Sedan den första november 2008 har metoden för framställning av muntlig bevisning i hovrätt ändrats. Med anledning av reformen ”En modernare rättegång” moderniserades rättegången i hovrätten. Moderniseringen innebar bland annat att ljud- och bildupptagning som gjorts i tingsrätten, i regel spelas upp som muntlig bevisning i hovrätten. Nu finns förslag på att den delen av hovrättsförSummary Since November 1st 2008, the method of presenting oral testimonies in the Swedish Court of Appeal has changed. Since the reform “More modern court proceedings” the trials in Court of Appeal have become modernized. The modernization meant, inter alia, that audiovisual recording that have been conducted at the Swedish District Courts are, as a rule, played at the Court of Appeal. The recordi
Syftet med denna studie är att undersöka hur kompositionsundervisningen ser ut på Gotlands Tonsättarskola. Jag vill få mer kunskap om hur lärare upplever ämnet komposition och hur de lägger upp sin undervisning. Metoden jag använder mig av är en kvalitativ intervjustudie där jag intervjuar fyra lärare som arbetar med kompositionsundervisningen på Gotlands tonsättarskola. Resultatet påvisar ett kreThe purpose of this study is to explore the education of composition at Gotlands Tonsättarskola. I want more knowledge about teachers' experience regarding the subject of composition and how they plan their teaching. I use the qualitative interview as a method, where I have interviewed four teachers who works with composition at Gotlands Tonsättarskola. My results show a creative teaching meth
EU:s regelverk om offentlig upphandling uppdaterades 2014 och snart kommer uppdateringen i den svenska lagtexten. Det blir nu ännu tydligare att det är tillåtet att ställa miljökrav vid offentlig upphandling. Det är en vanlig uppfattning att det inte går att upphandla varor, tjänster och byggnadsverk med bättre miljöprestanda eftersom att de traditionellt sett inte kan konkurrera med kriteriet ”This is a master’s thesis about green public procurement (GPP) in the construction sector, based on a legal dogmathic study and a case study. The legal dogmathic part focused on both EU-legislation and on Swedish legislation. The case study was performed on the municipal of Lund to understand how a small authority works with GPP. The study of EU-legislation shows that the possibility to request b
Disinhibition of the mechanistic target of rapamycin (mTOR) pathway has been observed in patients with loss-of-function variants in the disheveled, Egl-10, and pleckstrin domain-containing protein 5 (DEPDC5), and nitrogen permease regulator-like proteins 2 and 3 (NPRL2, and NPRL3) genes, which encode the components of GTPase activating protein Activity Toward Rags Complex 1 (GATOR1) complex. Evero
BackgroundPreliminary results from the SNAP trial presented at ESCMID Global 2025 reported a high incidence (19.8%) of acute kidney injury (AKI) in patients treated with (flu)cloxacillin for Staphylococcus aureus bacteraemia (SAB).ObjectiveIn Sweden, cloxacillin is used at lower daily doses, and the risk of nephrotoxicity has not been assessed in this setting.MethodsWe retrospectively evaluated re
ImportanceGuidelines for temperature control following out-of-hospital cardiac arrest (OHCA) are based on trials with end points of 180 days or fewer.ObjectivesTo investigate if targeted hypothermia, compared with targeted normothermia with early treatment of fever, affects functional outcome focusing on societal participation or cognitive functioning at 24 months in initially comatose OHCA survivImportanceGuidelines for temperature control following out-of-hospital cardiac arrest (OHCA) are based on trials with end points of 180 days or fewer.ObjectivesTo investigate if targeted hypothermia, compared with targeted normothermia with early treatment of fever, affects functional outcome focusing on societal participation or cognitive functioning at 24 months in initially comatose OHCA surviv
Background Inversions involving intron 22 (Inv22) of the F8 gene are detected in approximately 45% of all severe hemophilia A (HA) patients. Digital droplet polymerase chain reaction using milepost assays and multiplex ligation-dependent probe amplification (MLPA) allows robust diagnosis of inversions, copy number variations, and more complex rearrangements in F8 . Objectives A total of 350 HA pat
Background: The Peritoneal Cancer Index recorded at laparotomy is based on visual and palpable inspection of peritoneal surfaces for disease. This study aimed to analyze interobserver variation in assigning the lesion score (LS) and morphologic term (MT) to characterize peritoneal lesions (PL) and predict the probability of malignancy (POM) among surgeons with expertise in cytoreductive surgery (C
Background The aim of this systematic review and meta-analysis was to examine autoantibody positive individuals and define: (a) the relative risk of rheumatoid arthritis (RA) compared with autoantibody negative individuals and (b) the cumulative incidence of RA over time, in different populations. Methods A systematic literature search was performed in August 2025. Retrospective case control studi
Even if much is known regarding the effects of internet-delivered cognitive behaviour therapy (ICBT) for depression there are several topics that have not been studied. In this factorial design trial with 197 participants we investigated if clients in ICBT could select treatment modules themselves based on a selection of 15 tailored treatment modules developed for use in ICBT for depression. We co
Breastfeeding confers a wide range of benefits to mothers and children, and in many contextsmay continue for several years after the birth of a child. As a result, breastfeeding duringpregnancy (BDP) is a common occurrence throughout low- and middle-income countries.Nevertheless, yet there has been little research into its association with the health of breastfedchildren or the outcomes of the pre
The ongoing pursuit of advanced multicomponent magnetic nanomaterials with tailored functionalities for applications in data storage, spintronics, and biomedicine necessitates novel synthesis approaches beyond conventional template-based methods. In response, this thesis investigates the generation, self-assembly, and characterisation of largely little-known Fe0.10Ni0.40Co0.25Pt0.25 medium-entropy
