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ABSTRACT Radioimmunotherapy (RIT) consists of using monoclonal antibodies (mAbs) recognizing tumor-selective antigens, as carriers of cytotoxic radionuclides to tumor tissue. RIT has been effective in lymphoma but less successful in solid tumors. mAbs slowly diffuse from the vasculature into and through solid tumors, resulting in slow, limited accretion of antibodies. The outcome is a low tumor-to

We present spatial and dynamic information on the s = 1/2 distorted kagome antiferromagnet volborthite, Cu3V2O7(OD)(2) center dot 2D(2)O, obtained by polarized and inelastic neutron scattering. The instantaneous structure factor, S(Q), is dominated by nearest-neighbor pair correlations, with short-range order at wave vectors Q(1) = 0.65(3) angstrom(-1) and Q(2) = 1.15(5) angstrom(-1) emerging belo

The aim of this study was to establish whether or not a development of the complexity of the noun phrase, i.e. an increase in noun phrase elaboration could be observed in written L2 Swedish over time. To provide an insight to said development, three on L2 English previously tested and strongly correlating phrasal complexity measures, MLNP, MNPDep and WNPCx (Bulté 2013), were employed. A fourth mea

I denna uppsats har jag velat undersöka om de prosodiska skillnaderna mellan svenskan och franskan kan förklara de avvikelser från den franska normen som återfinns hos nästan alla svenska inlärare av franska, i det närmaste oberoende av hur länge man har studerat språket. Jag ville studera om skillnaderna kunde härledas till olikheterna mellan de båda rytmiska språktyperna stress-timing och syllab

This essays focus is to unravel the discourses concerning women by doing a historic-comparative qualitative content analysis on Malleus Maleficarum, written in 1486, and modern papal writings in order to compare the similar or different ways in which the ideal woman is understood. The reason for why these materials have been chosen is based on the influential spread these writing had or have, and

The thesis investigates how the problem of Critical Raw Material supply chains is represented within the European Critical Raw Materials Act of 2023. Bacchi’s ‘What's Problem Represented To Be’ approach has been adapted and utilised to explore what aspects of these supply chains are problematised. By highlighting how the problem of supply chains is represented, this research aims to uncover wh

Disney har sedan 30-talet legat i täten för tekniska och artistiska landvinningar och har med sina filmer byggt en kanon som gjort bolaget synonymt med animerad film. Denna uppsats syfte är att undersöka de estetiska beståndsdelar Disneys filmer är uppbyggda av, där fokus ligger vid färgsättningen av de tecknade filmerna. Med hjälp av semiotisk stilanalys behandlas färganvändningarnas utseenden oc

Enzyme engineering for a better future It is essential for many organisms on this planet to be able to digest plants. One of those organisms is the blue mussel, which uses certain enzymes in its stomach to break down sugar fibers in the algae that it eats. But how does this really work, and can we use it for anything? Plant cells have very strong walls, protecting them from environmental stress.

Colchicine may induce a myoneuropathy in patients with renal insufficiency. To date, myotonia has not been described in this disorder. We recently studied 4 patients treated with routine doses of colchicine who, in the setting of renal insufficiency, developed a severe myoneuropathy characterized by prominent myotonic discharges on electromyography. In addition, 1 of the 4 patients had profound cl

Next-generation sequencing (NGS) will soon be used for clinically heterogeneous, inherited disorders and the increasing number of disease-causing genes reported. Diagnostic laboratories therefore need to decide which NGS methods they are going to invest in and how to implement them. We discuss here the challenges and opportunities of using targeted resequencing (TRS) panels for diagnosing monogene

Aim: The aim of the study was to determine whether paediatric ataxia speech subscores are reliably applicable for international early-onset ataxia (EOA) databases. If so, we reasoned that ataxia speech subscores should be associated with ataxia scores and involve high interobserver agreement, including those for internationally applicable Scale for Assessment and Rating of Ataxia (SARA) syllable r

We describe two unrelated cases of ornithine aminotransferase (OAT) deficiency with rare neonatal presentation of hyperammonaemia. The diagnosis in the neonatal presentation of OAT deficiency is hampered as hyperornithinaemia is absent. Enzyme and mutation studies confirmed the diagnosis. OAT deficiency should be included in differential diagnosis of neonatal hyperammonaemia.

This study is concerned with the integration of negation in relation to two models of the processing of negation: (i) the two-step model (Lüdtke et al., 2008), according to which negation involves two representations where negation is ignored in the first representation, and (ii) the pragmatic view (Nieuwland & Kuperberg, 2008), which posits that negation can be integrated without delay if it

Paenibacillus larvae, causative agent of American Foulbrood (AFB), is the primary bacterial pathogen affecting honeybees and beekeeping. The main methods for controlling AFB are incineration of diseased colonies or prophylactic antibiotic treatment (e.g. tylosin), neither of which is fully satisfactory. The search for superior means for controlling AFB has led to an increased interest in the natur

Despite major advances in antibody discovery technologies, the successful development of monoclonal antibodies (mAbs) into effective therapeutic and diagnostic agents can often be impeded by developability liabilities, such as poor expression, low solubility, high viscosity and aggregation. Therefore, strategies to predict at the early phases of antibody development the risk of late-stage failure

Allogeneic islet transplantation can restore an insulin-independent state in C-peptide-negative type 1 diabetic patients. We recently reported three cases of surviving islet allografts that were implanted in type 1 diabetic patients under maintenance immune suppression for a previous kidney graft. The present study compares islet graft-specific cellular auto- and alloreactivity in peripheral blood

Fast kicker systems are required for the proposed upgrade of ALS to a diffraction-limited light source (ALS-U). The main approach is to have multiple stripline kicker magnets driven by inductive adders. The design details of the kicker structures and the inductive adder options will be discussed.