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Mice harbor ∼2800 intact copies of the retrotransposon Long Interspersed Element 1 (L1). The in vivo retrotransposition capacity of an L1 copy is defined by both its sequence integrity and epigenetic status, including DNA methylation of the monomeric units constituting young mouse L1 promoters. Locus-specific L1 methylation dynamics during development may therefore elucidate and explain spatiotemp

BACKGROUND: LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms following DNA damage. Recent reports suggest that L1 is mobile in epithelial tumours and neural cells but, paradoxically, not in brain cancers.RESULTS: Here, using retrotransposon capt

BackgroundFor advanced pancreatic cancer, pulmonary metastases (PM) have been considered favorable factors compared to metastases of other sites, but it remains unknown whether the prognosis of patients with synchronous liver and lung metastases is better than that of non-PM.MethodsData was derived from a two-decade cohort and included 932 cases of pancreatic adenocarcinoma with synchronous liver

Popular Abstract in Swedish Neutrofilen är den vanligaste vita blodkroppen och de tillhör det sk medfödda immunförsvaret. Under normala förhållanden är neutrofilerna inaktiva och cirkulerar i blodomloppet. Vid exempelvis en infektion utsöndras inflammatoriska aktiverande ämnen från vår kropp men även från oönskade mikroorganismer och detta gör att neutrofilerna aktiveras. Från att ha varit runda, Inflammation is a localized protective response in vascularized tissues and can be induced by microbial infection or cell and tissue injury. Polymorphonuclear neutrophils (PMN) are the most common white blood cells and are recognized as major cellular mediators of acute inflammation. PMN are highly mobile cells that possess regulated mechanisms for controlling the expression and activation of adhe

Per Mårtensson Tillämpning av SCORE-metoden på f.d BT Kemis södra område Syftet med denna uppsats har varit att tillämpa multikriteriaanalysen SCORE för att utreda vilket av tre åtgärdsalternativ som mest gynnar hållbar utveckling vid den kommande saneringen av det södra området på BT Kemi – samt att även utvärdera själva SCORE-metoden. Intresset för hållbar sanering har ökat i takt med att Remediation of contaminated sites may cause adverse negative effects like usage of non-renewable resources, high monetary cost, air emissions and an increased risk of accidents. Therefore, interest in sustainable remediation has increased in recent years. The aim with sustainable remediation is to integrate a holistic perspective on remedial projects and find the alternative that is considered bes

Enzymes of the xanthine oxidase family are among the best characterized mononuclear molybdenum enzymes. Open questions about their mechanism of transfer of an oxygen atom to the substrate remain. The enzymes share a molybdenum cofactor (Moco) with the metal ion binding a molybdopterin (MPT) molecule via its dithiolene function and terminal sulfur and oxygen groups. For xanthine dehydrogenase (XDH)

In recent years, hydrogels have been demonstrated as simple and cheap additives to improve the optical properties and material stability of organometal halide perovskites (OHPs), with most research centered on the use of hydrophilic, petrochemical-derived polymers. Here, we investigate the role of a peptide hydrogel in passivating defect sites and improving the stability of methylammonium lead iod

Human carbonyl reductase 1 (CBR1), that is one of the enzymes responsible for the reduced efficiency of treatments by the antineoplastic agents anthracyclines, was functionally expressed in Saccharomyces cerevisiae. CBR1 was purified and kinetically characterised using daunorubicin as substrate. CBR1-catalysed reduction of daunorubicin followed an apparent Michaelis-Menten kinetics with K-M = 85.2

Abstract in UndeterminedRelevant source area of pollen (RSAP) and pollen productivity for 11 key taxa characteristic of the pasture woodland landscape of the Jura Mountains, Switzerland, were estimated using pollen assemblages from moss polsters at 20 sites. To obtain robust pollen productivity estimates (PPEs), we used vegetation survey data at a fine spatial-resolution (1 x 1 m(2)) and randomize

Popular Abstract in English Proteins are a big biological molecules that help cells to function. Proteins play important roles in all vital processes of the living cell, transporting molecules, speeding up chemical reactions, supporting structure of other proteins and the cell, helping the cell to move. Various disease-causing agents (e.g. bacteria and viruses) are constant threat to us. It is thMost drugs act on biomacromolecules. The Cost of developing new drugs is very high. A method to accurately predict binding affinities would be very useful. We have studied molecular mechanics with generalised Born and surface--area solvation (MM/GBSA) and alchemical free energy perturbation methods (FEP) for use in calculations of ligand binding energies. For the MM/GBSA method we have tested: Ca

We have studied the convergence of QM/MM calculations with respect to the size of the QM system. We study a proton transfer between a first-sphere cysteine ligand and a second-sphere histidine group in [Ni,Fe] hydrogenase and use a 446-atom model of the protein, treated purely with QM methods as a reference. We have tested 12 different ways to redistribute charges close to the junctions (to avoid

Proton Beam Therapy (PBT) is an increasingly utilised modality for treating tumours by utilising the physical properties of accelerated proton beams. This review explores the development of PBT, its dosimetric advantages over conventional x-ray-based radiotherapy, and the rationale behind its use in paediatric oncology whilst simultaneously considering the various challenges associated with its de

Forskare Kontaktinformation E-post: bengt [dot] lundell [at] jur [dot] lu [dot] se Telefon: +46 46 222 10 94Organisation Juridiska institutionen Rumsnummer: 320 Hämtställe: 56 WebbplatsBengt Lundells profil i Lunds universitets forskningsportalAndra roller Forskare Offentlig rätt Publikationer Visar av publikationer. Sorterade efter år och sen titel. Filtrera efter typ AllaArtikel i tidskriftBokDe

https://www.jur.lu.se/bengt-lundell - 2026-05-02

In contrast to sparse keypoints, a handful of line segments can concisely encode the high-level scene layout, as they often delineate the main structural elements. In addition to offering strong geometric cues, they are also omnipresent in urban landscapes and indoor scenes. Despite their apparent advantages, current line-based reconstruction methods are far behind their point-based counterparts.

Background: Chronic obstructive pulmonary disease (COPD) is a severe condition affecting millions worldwide, leading to numerous annual deaths. The absence of significant symptoms in its early stages promotes high underdiagnosis rates for the affected people. Besides pulmonary function failure, another harmful problem of COPD is the systemic effects, e.g., heart failure or voice distortion. Howeve

The use of millimetre-wave frequencies in Fifth generation New Radio has lead to high path loss due to radio propagation environment. Simultaneously, high data rates is a must for current products due to high market demand. This requirement accounts for efficient tracking of the best beam for the user equipment to stay connected to it. Current products at Ericsson use such methods of beam manageme

Framsteg inom forskningsområden som maskininlärning, signalbehandling och sensorteknik möjliggör automatisk klassificering av sjukdomssymptom. Läkare kan bedöma symptom vid Parkinsons sjukdom genom att granska videomaterial. Kan vi lära datorer att göra samma bedömning endast utifrån data från sensorer? Parkinsons sjukdom, som årligen drabbar ungefär 2000 personer i Sverige, leder till att nervceThe recent progress in wearable sensor technology, signal processing and machine learning enables novel applications in fields such as automatic disease symptom tracking and classification. In this project, data from an ongoing Parkinson’s disease study at the Lund University Hospital is gathered and analyzed, and classification models of varying complexity for symptom severity are evaluated. The

The aim of realistic graphics is the creation of images that provide the same visual responses that a viewer would experience in a real world scene. There are different rendering techniques that produce high dynamic range images that capture the full intensity range of a scene. These images cannot be reproduced on a standard display due to limitations in device hardware. Therefore, a high dynamic