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NLRs are recently discovered PRRs detecting substructures of peptidoglycans and triggering innate immunity. NLRs are expressed in several cell types, but the presence in human B lymphocytes is still unknown. This study aimed to investigate expression and function of NLRs in human B lymphocytes. B cells were isolated and analyzed for mRNA and protein expression. The functional responsiveness of NOD

BACKGROUND: Refugee women have a high risk of coronary heart disease with low physical activity as one possible mediator. Furthermore, cultural and environmental barriers to increasing physical activity have been demonstrated. The aim of the study was to evaluate the combined effect of an approximate 6-month primary health care- and community-based exercise intervention versus an individual writte

Even though B-lymphocyte development is one of the best understood models for cell differentiation in the hematopoetic system, recent advances in cell sorting and functional genomics has increased this understanding further. This has suggested that already early lymphoid primed multipotent progenitor cells (LMPPs) express low levels of lymphoid restricted transcripts. The expression of these genes

BACKGROUND: /st> Previous studies have indicated that autoantibodies may be detected years before the clinical onset of rheumatoid arthritis (RA). Cartilage biomarkers, such as cartilage oligomeric matrix protein (COMP), have not been studied previously in samples collected before the diagnosis of RA. METHODS: /st> Between 1991 and 1996, 30 447 subjects were included in the Malmö Diet Cancer Study

Acute thromboembolic occlusion in the superior mesenteric artery (SMA) is a condition with high mortality and morbidity. Multi-detector computerised tomography with intravenous contrast enhancement (MDCTiv) may improve diagnostic accuracy and survival. Patients with acute SMA occlusion were identified between 2004 and 2008 at Malmö University Hospital, Sweden. Medical records were analysed. Each M

OBJECTIVE:: The risk factor pattern underlying a parental history of myocardial infarction (MI) is incompletely understood. We examined whether a parental history of clinically verified early MI may promote development of insulin resistance, obesity and the metabolic syndrome (MetS). METHODS:: One hundred and seventy-four offspring to patients with clinically verified MI before 60 years of age i

The fibrillation process of the islet amyloid polypeptide (IAPP) and its fragment (IAPP((20-29))) was studied by means of Thioflavin T (ThT) fluorescence and transmission electron microscopy in the absence and presence of N-isopropylacrylamide:N-tert-butylacrylamide (NiPAM:BAM) copolymeric nanoparticles. The process was found to be strongly affected by the presence of the nanoparticles, which reta

Impact of SBP vs. DBP decrement during orthostasis on cardiovascular events in hypertension is not clear.

The objectives of this study are to develop and demonstrate an approach to improve emergency response capability by strengthening individual and organisational learning from the evaluations of specific emergency responses. An approach was developed based on theories of individual and organisational learning. It was applied to evaluations of three instances of emergency response in the city of Malm

The role of anyonic statistics stands as a cornerstone in the landscape of topological quantum techniques. While recent years have brought forth encouraging and persuasive strides in detecting anyons, a significant facet remains unexplored, especially in view of connecting anyonic physics to quantum information platforms—whether and how entanglement can be generated by anyonic braiding. Here, we d

IntroductionThe evidence for assessing whether a single stab injury to the trunk was inflicted by another person in an assault or self-inflicted has primarily been derived from autopsy studies. In this study, we investigate whether victim demographics, crime scene circumstances, and the injury characteristics of assault survivals are interchangeable with homicide characteristics, with a specific f

This thesis aims to investigate the novel physics around Majorana bound states (MBSs). MBSs are quasiparticle excitations predicted to exist in topological superconductors. Due to the inherent protection they obtain from their topology, they have long been regarded as a promising setup to build a topologically protected quantum computer. Apart from this very practical application, they continue to

The Majorana tetron is a prototypical topological qubit stemming from the ground-state degeneracy of a superconducting island hosting four Majorana modes. This degeneracy manifests as an effective nonlocal spin degree of freedom, the most paradigmatic signature of which is the topological Kondo effect. Degeneracies of states with different fermionic parities also characterize minimal Kitaev chains

This study presents the fabrication of all-dielectric silicon-based twisted L-shape metamaterials using a two-step electron-beam glancing angle deposition approach. Systematic chiroptical characterization and optimization are performed through Mueller matrix generalized spectroscopic ellipsometry and finite element modeling, demonstrating tunable, broadband chirality response with potential applic

Tuning the spectral and directional characteristics of thermal emission is critical for advancing technologies such as thermophotovoltaics (TPVs), passive thermal radiative cooling (PTRC), and solar thermophotovoltaics (STPVs), yet scalable fabrication methods remain limited. Here, femtosecond laser surface processing (FLSP), a top-down ablation and re-solidification approach is employed, to creat

Cardiovascular disease (CVD) is the leading cause of death in Europe, with myocardial infarction (MI) being one of its most severe manifestations. While many risk factors for CVD are well known, occupational exposures remain relatively understudied—especially in analyses that adjust for co-occurring workplace exposures. This study aimed to examine the association between occupational exposure to c

Peripheral nerve tumours, most commonly schwannomas and neurofibromas, might present significant challenges by eliciting physical symptoms and emotional distress. We aimed to explore patients’ expectations, perceptions, and experiences regarding their diagnosis and the surgical treatment of a nerve tumour in the upper limb. Fourteen adults (10 women, 4 men; age range 35–85) from two Swedish hand s