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With the urgent demand for ultralow-temperature refrigerators worldwide, the operation reliability and stability of the refrigeration system becomes greatly crucial. In this study, a -80 oC ultralow-temperature cascade refrigeration system (CRS) is developed. From aspects of global warming potential (GWP) and ozone depletion potential (ODP), the environmentally friendly refrigerants R290 and R170

Enucleation is a crucial event during the erythropoiesis, implicating drastic morphologic and transcriptomic/proteomic changes. While many genes deletion lead to failed or impaired enucleation have been identified, directly triggering the erythroid maturation, particularly enucleation, is still challenging. Inducing enucleation at the desired timing is necessary to develop efficient methods to gen

Objectives To study neutrophil gelatinase-associated lipocalin (NGAL) levels in peripheral blood in SLE, and to propose a mechanism by which neutrophils secrete NGAL on stimulation with immune complexes (IC). Methods NGAL was measured by ELISA in two independent Swedish SLE cohorts acting as exploratory and validation cohort (n=124 and n=308, respectively), disease controls (n=38) and healthy cont

Small angle neutron scattering (SANS) has been employed to examine the self-assembly behaviour of sodium 5-tetradecyl furan-2-sulfonate (STFS), an emerging anionic surfactant, in bulk dilute solutions. STFS was also studied in binary and ternary mixtures with a common non-ionic (hexaethylene glycol monododecyl ether, C12E6) and anionic (sodium dodecyl sulfate, SDS) surfactant to explore the shape,

Background: Evidence on psychological outcomes of gaming disorder (GD) is still scarce. This study aimed to investigate the mediating role of sleep hygiene in the relationship between GD and psychological distress (depression and anxiety) among Iranian adolescents. Methods: This was a cross-sectional study among school students in Qazvin city, Iran. We administered GD, anxiety, and depression ques

Patients with systemic lupus erythematosus (SLE) face an approximately 30 % risk of thrombosis post-diagnosis. However, there remains significant knowledge gaps regarding causative mechanisms, and there is a lack of specific antithrombotic guidelines. This systematic review aims to examine the existing literature regarding the mechanisms contributing to thrombosis risk in SLE, focusing on five pre

Background: Community-acquired pneumonia (CAP) was one of the most common causes of death in the European Union in 2017. Severity and mortality of CAP increase with age and an aging European population will require increased planning for prevention, control, and management of CAP. The purpose of this study was to provide an updated population-based estimate of the incidence of CAP requiring hospit

Objectives: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) libraries have limited capabilities for identification of Streptococcus bovis/Streptococcus equinus-complex (SBSEC) subspecies. The objective was to develop and validate novel MALDI-TOF MS libraries adapted to diagnostic culturing and sampling conditions for improved identification of SBSEC subs

Objectives: Studies supporting therapeutic drug monitoring to biopharmaceuticals in SLE are scarce. We aimed to assess anti-drug antibody (ADA) occurrence in belimumab-treated SLE patients and associations between belimumab concentrations and clinical response, serological outcomes and adverse events. Methods. We included 100 patients treated with intravenous belimumab. Clinical data and biologica

Soft-x-ray holography which utilizes an optics mask fabricated in direct contact with the sample, is a widely applied x-ray microscopy method, in particular, for investigating magnetic samples. The optics mask splits the x-ray beam into a reference wave and a wave to illuminate the sample. The reconstruction quality in such a Fourier-transform holography experiment depends primarily on the charact

The photoactivity of rutile TiO2(110) renders its surfaces of particular interest for the study of surface reactions. In particular, rutile TiO2(110) surfaces are active for hydrogen production, both via the water splitting process and via ethanol degradation under ultraviolet illumination. The selective photocatalytic dehydrogenation of rutile TiO2(110) is not fully understood yet, and an importa

The medical imaging technique called “ultrasound optical tomography” (UOT) entails light scattered in tissue that is given spatial information by interacting with an ultrasound field, thus allowing for molecular information to be imaged with ultrasonic resolution. This thesis discusses how UOT can be implemented, with most attention put toward the implementation using spectral-hole-burning filters

An appropriate production of mature blood cells, or hematopoiesis, is essential for organismal health and homeostasis. In this developmental cascade, hematopoietic stem cells (HSCs) differentiate into intermediate progenitor types, that subsequently give rise to the many distinct blood cell lineages. Here, we describe tools and methods that permit for temporal and native clonal-level HSC lineage t

There is a need for consensus on the recommendations for follow-up of children and adolescents with celiac disease. Objectives: To gather the current evidence and to offer recommendations for follow-up and management. Methods: The Special Interest Group on Celiac Diseases of the European Society of Paediatric Gastroenterology Hepatology and Nutrition formulated ten questions considered to be essen

OBJECTIVES: To increase the proportion of individuals with hypertension obtaining a blood pressure (BP) of less than 140/90 mmHg by improving the management of hypertension in daily life from a person-centred perspective.METHODS: In this unblinded randomized controlled trial, we tested an interactive web-based self-management system for hypertension. A total of 949 patients with hypertension from

Background: Untreated celiac disease (CD) patients have increased levels of blood glutamine and a lower duodenal expression of glutaminase (GLS). Intestinal gluconeogenesis (IGN) is a process through which glutamine is turned into glucose in the small intestine, for which GLS is crucial. Animal studies suggest impaired IGN may have long-term effects on metabolic control and be associated with the

Mismatch between adjacent atomic layers in low-dimensional materials, generating moiré patterns, has recently emerged as a suitable method to tune electronic properties by inducing strong electron correlations and generating novel phenomena. Beyond graphene, van der Waals structures such as three-dimensional (3D) topological insulators (TIs) appear as ideal candidates for the study of these phenom

Background: The prevalence of celiac disease in the general population is mainly unknown in most of sub-Saharan African countries. The aim of this study was to determine the incidence of celiac disease autoimmunity (CDA) and its associations with latent Mycobacterium tuberculosis (LMTB) and Helicobacter pylori (HP) infections in Ethiopian children aged 4 years in an HLA genotyped cohort study. Met

We demonstrate how the individual mirrors of a high-quality Kirkpatrick-Baez (KB) mirror system can be aligned to each other to create an optimally focused beam, through minimizing aberrations in the phase of the ptychographically reconstructed pupil function. Different sources of misalignment and the distinctive phase artifacts they create are presented via experimental results from the alignment