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Gene Therapy for Neurological Disorders

Popular Abstract in Danish Genterapi er en attraktiv terapiform mod neurologiske lidelser som Parkinsons sygdom og epilepsi af flere grunde. Gener med en terapeutisk effekt kan introduceres lokalt ved præcise injektioner i det syge væv, hvor genproduktet kan frigives fra nerveceller i respons til aktivitet i det omgivende væv. Ved genterapi omgås den forhindring som blod-hjernebarrieren udgør, ligGene therapy is an attractive strategy for neurological disorders, such as Parkinson’s disease and epilepsy, for several reasons. Introduction of genes with a therapeutic potential can be achieved locally, by accurate injections in the compromised tissue, and release of a transgene therapeutic substance can be regulated by the surrounding host neural circuitry. The gene therapy approach circumvent

It Breaks a Man's Heart - Socioeconomic Differences in the Onset of Cardiovascular Disease in Contemporary Sweden

Popular Abstract in English This doctoral thesis investigates the onset of cardiovascular disease with a focus on socioeconomic differences as explanatory factors. Analyzing a contemporary population of natives and foreign-born individuals in Sweden, socioeconomic status is operationalized through a variety of measures. The importance of this study is found in the high cost of cardiovascular interThis doctoral thesis investigates the relationship between socioeconomic status and the onset of cardiovascular disease in a contemporary population of natives and foreign-born individuals in Sweden. The complexity of individual socioeconomic characteristics and the interrelationship with other cardiovascular risk factors is the focus of the studies in this thesis. As in most developed countries,

Realtidsövning för lärande i sammanhang

Realtidsövning för lärande i sammanhang är en övning i ett verklighetstroget scenario där studenterna tar beslut och agerar i realtid, samt systematiskt reflekterar över dessa beslut och handlingar. Det är detta systematiska och lärarledda växelspel mellan självständigt agerande och reflektion som är realtidsövningens viktigaste särdrag. Denna övningsform kan vara ett värdefullt verktyg i akademis

Transactional Analysis Psychotherapy : Three Methods Describing a Transactional Analysis Group Therapy

Transaktionsanalytisk psykoterapi - Tre metoder som beskriver en transaktionsanalytisk gruppterapi Avhandlingen är baserad på en ett årig Transaktionsanalytisk gruppterapi. Transaktionsana-lysen (TA) är en integrerad, relationell psykodynamisk terapi med rötter i den humanistiska psykologin. Den beskrivs i den internationella TA föreningen, ITAA:s utbildningsmanual (ITAA hemsida, 2011) som "en peTransactional Analysis Psychotherapy - Three Methods Describing a Transactional Analysis Group Therapy The overall aim of the present thesis was to enhance and revive the practical understanding of the active ingredients in Transactional Analysis Psychotherapy (TA) and to define and lay down elements of TA, which makes it a distinct and replicable method of treatment. The thesis includes three em

Factors Affecting Business Process Management System Adoption and Diffusion

In recent years, business process management (BPM) is a vital methodology or strategy to drive business management agilely. It is an approach that can make the organization achieve effectiveness and efficiencies through creating and ameliorating its business processes according to its business strategies, objectives, and requirements. There is no doubt that dynamic and flexible business processes

Lotsningens bidrag till sjösäkerhet

This master’s thesis aims to investigate how pilotage contributes to maritime safety and if its criteria can be more risk-based in Sweden. The theory of Resilience Engineering was applied to maritime safety which has extended the concept further. Several aspects of how pilots contribute to maritime safety were identified within the literature and empirical studies. These aspects were the pilots

Framtidens aktiehandel - Strategier för virtuella marknadsplatser

Sammanfattning Avregleringen av den finansiella marknaden har skapat förutsättningar för alternativa marknadsplatser. Företag kan i dag välja att notera sig på icke traditionella börser som inte är knutna till en fysisk handelsplats. För att skapa förtroende och långsiktighet för dessa virtuella marknadsplatser krävs det att vikt läggs vid relationen till kunderna. En del i detta är att ta hänsyn

Esidai Enkaji - Interior for Basecamp Explorer Tented Camps

Master project made at Lund Institute of Technology Department of Design Sciences, division of Industrial Design in cooperation with Basecamp Explorer. Basecamp Explorer wanted me to be involved in the development of the interior of the guest tents in their camp in Masai Mara, Kenya and the Pyrenees, France. Basecamp Explorer runs ecological tourism destinations on a handful of places in the world

Nature and the Social Sciences : Examples from the Electricity and Waste Sectors

The book has two interrelated objectives. One objective is meta-theoretical and concerns the exploration of theoretical debates connected to issues of studying society and environmental problems; another objective is empirical/analytical, referring to the analysis of "green" public participation in the electricity and waste sectors in Sweden, and partly in the Netherlands as well as the UK. The me

Brandförlopp och brandspridning i stora lokaler : en vägledning förval av beräkningsmodeller : översikt utförd på uppdrag av BRANDFORSK

Området industribränder kan som det redovisats i denna rapport sammanfattas i bl.a. följande punkter: Det existerar ett antal principiellt skilda beräkningsmetoder och dessa inkluderar okomplicerade beräkningsuttryck, zon-modeller och fältmodeller. Val av metod maste bero på ändamalet med beräkningen, någon universalmetod eller universaldatorprogram existerar inte och kan inte ens skönjas. En val

Towards Better Urban Spaces in Harmony with Microclimate: Urban design and planning regulations in hot dry Damascus, Syria

Popular Abstract in English This study concerns the city of Damascus in the Syrian Arab Republic. Damascus is a city where the current urban form is characterized by wide streets and lack of shade as well as limited amount of green areas, which negatively affect the microclimate and thermal comfort. This study is mainly focused on residential streets and how the urban planning regulations affect tThis research is an attempt to develop further understanding of the relationship between microclimate, thermal comfort, urban design and outdoor space users in the hot dry city of Damascus. This is done by studying the impact of urban regulations on microclimate in different urban design patterns in Damascus. This study also aims to investigate the behaviour of different thermal comfort indices an

Ecotypic divergence in Crepis tectorum (Asteraceae): inferring trait lability and correlational constraints from hormonally manipulated phenotypes

Despite long‐standing interest in the evolutionary role of plant hormones, relatively few studies have used hormonally manipulated phenotypes to address questions about phenotypic evolution in plants. In the present investigation, I subjected plants of Crepis tectorum subsp. pumila to simple gibberellin (GA) treatments under both field and greenhouse conditions to assess developmental lability andDespite long‐standing interest in the evolutionary role of plant hormones, relatively few studies have used hormonally manipulated phenotypes to address questions about phenotypic evolution in plants. In the present investigation, I subjected plants of Crepis tectorum subsp. pumila to simple gibberellin (GA) treatments under both field and greenhouse conditions to assess developmental lability and

Tillbaka till dåtiden? : Om bibelvetenskapens roll och metoder : En replik till Joel Halldorf

The exegetical subjects have a particular interdisciplinary role within academia, implying that their responsibilities and significance are – and should be – under constant debate. In his article, church historian Joel Halldorf, argues for the overt use of theological interpretations (in the narrow sense of "normative theology") in the exegetical discipline. Halldorf thereby highlights some curren

Microvascular Complications and Predictors for Mortality in Patients with Type 2 Diabetes and Foot Ulcers

A diabetic foot ulcer (DFU) is a common and serious complication of diabetes. It is today the leading cause of amputations and is associated with both increased morbidity and mortality. Individuals with DFU have 2.5 times higher mortality rates compared to patients with diabetes but without DFU, a risk that persists even after ulcer healing. Macrovascular complications, such as a higher burden of A diabetic foot ulcer (DFU) is a common and serious complication of diabetes. It is today the leading cause of amputations and is associated with both increased morbidity and mortality. Individuals with DFU have 2.5 times higher mortality rates compared to patients with diabetes but without DFU, a risk that persists even after ulcer healing. Macrovascular complications, such as a higher burden of