Filetype
Malignant melanoma has the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has very limited possibilities for cure. Recently, several protein kinase inhibitors and immune modifiers have shown promising clinical results but drug resistance in metastasized melanoma remains a major pr
Klimatet har varit relativt stabilt under den nuvarande interglaciala epoken (Holocen) som inleddes för ungefär 11 700 år sedan. Genom klimatrekonstruktioner från olika geologiska arkiv såsom iskärnor, sjösediment och torvmossar har det ändå påvisats att snabba förändringar i klimatet har inträffat under denna epok. En sådan tidsperiod inträffade för omkring 2800 år sedan och den är intressant ur Geological archives have shown periods of abrupt climate change in the relatively stable Holocene epoch (last ca. 11 700 years). One of these periods was around 2800 cal BP. Several records, mainly from Europe, reveal a shift towards wetter, cooler and windier conditions. There are, however, indications for a global extent of the climate change. The climate change coincides with a distinct increas
BACKGROUND: Changes in glycosylation of serum proteins are common, and various glycoforms are being explored as biomarkers in cancer and inflammation. We recently showed that glycoforms detected by endogenous galectins not only provide potential biomarkers, but also have different functions when they encounter galectins in tissue cells. Now we have explored the use of a combination of two galectin
Popular Abstract in Swedish Yrsel är ett mycket vanligt symtom bland patienter inom olika specialiteter inom sjukvården. Orsaken bakom symtomen kan ligga i neurologiska sjukdomar, sjukdomar i innerörats balansorgan samt i psykiatriska sjukdomar, framför allt ångestsjukdomar. Medicinska undersökningar leder inte alltid till att orsaken till yrseln konstateras i en specifik sjukdom och ibland kan maDizziness is a common problem and it often co-exists with anxiety. Level of anxiety is the best predictor of handicap for dizzy patients. There is diagnostic controversy and few treatment programs for such patients. These patients can be labeled as panic disorder with agoraphobia or by the concept of Phobic Postural Vertigo which is characterized by dizziness or imbalance in standing or walking de
Målet med projektet var att analysera problem med arbete i kyla i mjölkproduktionsanläggningar vad gäller förekomst, frekvens och skaderisk samt att föreslå åtgärder för förbättringar. Projektet bestod av två delar: Del 1. En fältstudie, som genomfördes dels i Uppsalatrakten, dels i Västerbottens län. Del 2. En enkätstudie, riktad till Lantbrukshälsans medlemmar i norra regionen. Fältstudierna omfThe aim of the project was to analyse problems with cold when working in dairyfarms with respect to prevalence, frequency and risk for injuries and to propose measures for improvements of thermal conditions. The project comprised two parts: a field study and a questionnaire survey. The field studies were performed at seven dairy-farms in the Uppsala region and six dairy-farms in the northern regio
Popular Abstract in English Large market-driven software companies face new challenges in requirements engineering and management that emerged due to their recent extensive growth. At the same time, the pressure generated by competitors’ and users’ expectations demands being more competitive, creative and flexible to more quickly respond to a rapidly changing market situation. In the pursuit of stLarge market-driven software companies face new challenges in requirements engineering and management that emerged due to their recent extensive growth. At the same time, the pressure generated by competitors’ and users’ expectations demands being more competitive, creative and flexible to more quickly respond to a rapidly changing market situation. In the pursuit of staying competitive in this co
Popular Abstract in Swedish Ledgångsreumatism är en kronisk autoimmun sjukdom, som framföra allt angriper lederna, och orsakar smärta, stelhet och svullnad. Sjukdomens svårighetsgrad kan variera kraftigt och ett vanligt sätt att värdera svårighetsgraden av sjukdomen är att mäta antikroppar (till exempel reumatoid faktor) i blodet. De som har antikroppar har oftast en svårare sjukdom än de som inteRheumatoid arthritis (RA) is 4-6 times more common in women than men during the fertile years. For women, the incidence peaks shortly after menopause, and for men the risk is greater with higher age, when androgen levels drops. Sex hormones have been suggested to play a part in the pathogenesis, since low testosterone levels have been noted in men with RA and pregnancy has an ameliorating effect o
Popular Abstract in Swedish Förståelse av hjärtats pumpförmåga är av yttersta vikt för att kunna behandla patienter med hjärtsjukdom, framförallt hjärtsvikt. Studier av hjärtat har av naturliga skäl framförallt gjorts med öppen bröstkorg eller med hjärtat uttaget ur kroppen, och detta påverkar hjärtats pumpning. Magnetresonans-kameran gör det möjligt att avbilda hjärtat i alla delar av hjärtcykelnCardiac pumping physiology is important for understanding the pathophysiology of patients with cardiac disease. MRI gives the opportunity to measure volumes and flow non-invasively with high accuracy and precision. This thesis examines some aspects on cardiac pumping physiology. Study I showed that the total heart volume in humans decreases during systole by ~8 % (range 5-11 %), and anatomically i
Popular Abstract in Swedish Svenskan är ett s.k. V2-språk, dvs. det tempusböjda verbet står på andra plats i en deklarativ sats (en påståendesats) oavsett vilken typ av led som står i satsens första position. V1-ordföljd, där det tempusböjda verbet alltså står först i satsen, förknippas normalt med interrogativa satser (frågesatser) av typen ja/nej-frågor, t.ex. "Kommer du på fredag?". Icke desto The topic of the present thesis is V1 declaratives in spoken Swedish. Such constructions constitute an interesting object for research due to the fact that Swedish is a V2 language where V1 word order is grammaticalized for yes/no questions. Hitherto we have lacked a thorough study of the phenomenon. Therefore this thesis aims at investigating V1 declaratives in spoken Swedish from different point
OBJECTIVES: Prostate specific antigen (PSA) is a widely used and clinically valuable marker for prostate disease. In order to enable the development of new PSA assays and progress the understanding of the biology of PSA we have analyzed PSA in seminal plasma. Design and methods PSA in seminal plasma from men attending a fertility clinic and healthy controls was analyzed using SDS-PAGE, Western blo
Variation in transcription factor 7-like 2 (TCF7L2), the strongest genetic risk factor for type 2 diabetes (T2D), may play a role in prostate cancer (PCa) depending on lifestyle factors. The aims of this study were to determine if TCF7L2 rs7903146 is associated with risk of PCa and if the association is modified by lifestyle factors independently of T2D status.
Self-renewal of hematopoietic stem cells (HSCs) and leukemia-initiating cells (LICs) has been proposed to be influenced by low oxygen tension (hypoxia). This signaling, related to the cellular localization inside the bone marrow niche and/or influenced by extrinsic factors, promotes the stabilization of hypoxia inducible factors (HIFs). Whether HIF-1α can be used as a therapeutic target in the tre
The influence of trauma (acute pancreatitis) or total parenteral nutrition (TPN) on pancreatic islet hormone secretion in relation to islet expression of inducible nitric oxide synthase (iNOS) was investigated. Acute pancreatitis resulted in an impaired glucose-stimulated insulin secretion (GSIS) which was found to be parallelled by a marked expression of iNOS and an exaggerated NO production in t
Colon cancer is common in both developed and developing countries, and is responsible for at least 600,000 deaths globally every year. It is therefore the second most common cause of cancer-related mortality. Extensive studies are being conducted worldwide to find more effective drugs that can be used in cancer treatment. In these studies, phytochemicals have proven to be good sources for drug dis
Popular Abstract in English The eye is a complex device in charge of producing clear and sharp images of the outside world. While some people need glasses early on in their lives, others have nearly perfect vision until, all of a sudden, they have to hold books or documents further and further away from their eyes to be able to read them and eventually have to resort to reading glasses. This visuaHealthy eye lenses are transparent and flexible, able to adapt shape in order to focus on far away and close-by objects. With age, however, this flexibility is lost, leading to a condition known as presbyopia. This vision disorder where close-by objects appear blurred commonly starts around the age of 40. The aim of this thesis is to elucidate the molecular origin of the gradual hardening of the c
Every year, there are more than 2500 new international students coming to Lund University and starting their higher education path. A higher number of foreign students increased the international competitiveness of Lund University, but at the same time the international students had to face many problems for instance, culture shock and language barriers. In this report we focused on issues in teac
Popular Abstract in Swedish Inflammation is a protective response against injury or infection (the invading microbes or their toxins) with the aim being the removal of causal agent followed by the repair process. Without inflammation, infections would go unchecked and wounds would not heal. However, inflammation is like a double-edged sword. Though it is mainly a protective response, some times, iThe pro-inflammatory mediator, Leukotriene D4 (LTD4) is a product of arachidonic acid cascade and has been implicated in asthma and inflammatory bowel diseases. Prolonged inflammatory conditions like ulcerative colitis increases the risk for the development of cancer and the factors that induce the chronic immune response remain uncertain. In this context, in the present study, we examined if expo
Popular Abstract in Swedish The overall interest pursued in this thesis is how the former socialist economies of Central and Eastern Europe can build strong and dynamic systems of innovation. The purpose of the thesis is to investigate the dynamics and evolution of the telecommunications system of innovation in Estonia from the late Soviet period to Estonia's EU accession, and to provide an in-depThe overall interest pursued in this thesis is how the former socialist economies of Central and Eastern Europe can build strong and dynamic systems of innovation. The purpose of the thesis is to investigate the dynamics and evolution of the telecommunications system of innovation in Estonia from the late Soviet period to Estonia's EU accession, and to provide an in-depth explanation of how innova
Hexavalent chromium (Cr(VI)) can induce oxidative stress, genomic instability, and epigenetic modifications. In occupational settings, Cr(VI)-exposed workers may also be exposed to other toxicants, such as elements besides Cr, and per- and polyfluoroalkyl substances (PFAS). However, research on the extent of these co-exposures and their combined effects remains limited. The objective of this study
Since its development in the 1980s, spark ablation has been widely used to produce nanoparticles (NPs) in the aerosol phase, effectively eliminating surface contamination common in other generation methods (Schmitt-Ott, 2019). This is a significant advantage, as the surface of NPs plays a crucial role in applications such as sensing and catalysis. Additionally, spark ablation enables the productio
